Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

Song, Shibo; Xu, Ying; Zhou, Bingsheng

doi:10.1016/j.chemosphere.2006.01.033

Cited by 122 publications

(46 citation statements)

References 41 publications

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“…Whereas, Se induced a non-significant change in serum Glutathione peroxidase compared with control group. The long-term treatment with OP causes a gradual depletion of GPx, and GST (Song et al, 2006). Our results were compatible also with Fang et al, (2002).…”

Section: Effect Of Profenofos On Antioxidants Activitysupporting

confidence: 80%

Protecting Role of Selenium on the Cytotoxic Effect of Profenofos on Rabbit Fertility

Abdel-Rahman¹,

El-Metwally²,

El-Hallawany³

et al. 2017

AJVS

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Key words:Profenofos -Histopathology-Caspase-3 -Biochemical-HormonesAntioxidants-Reproductive toxicity -Selenium-Liverkidneys -Rabbits.Profenofos is an Organophosphorous compound and acaricide used in Egypt with cumulative toxic effects causing reproductive dysfunction and increase in reactive oxygen species production. Protective and anti-oxidant effects of selenium can improve the activity of radical scavenger. So, the aim of this study was to elucidate the protective effects of Selenium against reproductive toxicity induced by Profenofos in male and female New Zealand rabbits (n=18). Three experimental groups (3 males and 3 females per each group) receiving a combination of Profenofos (70 mg/ kg b. w.) and/or selenium in drinking water (25 mg/ kg b. w.) for 90-day was divided as follows: non treated (control), Profenofos alone and Profenofos + selenium group. Profenofos caused a decrease in body and organs weights compared to control group. It had a fetotoxic effect resulting in a significant reduction in pregnancy rate and the number of viable feti in treated animals. Also, Profenofos caused a significant elevation in ALT, AST, MDA, urea and creatinine, while a significant decrease was noticed in SOD, GSH, testosterone, estrogen and progesterone in all treated rabbits compared to control group. Concomitant administration of selenium with Profenofos alleviated the induced alterations. In addition to, histopathological results revealed that testes, epididymis, ovary and uterus alterations represented by degenerative and inflammatory changes as a result of Profenofos exposure. Profenofos had a carcinogenic effect on uterus as leiomyoma with rhabdomyosarcoma which gave positive immunoreactivity with Desmin and Smooth muscle actin. Also, Profenofos caused histopathological and histochemical effects in liver and kidney tissues. There was intensive positive immunoreactivity for caspase-3 (dark brown granules) was observed in the cytoplasm of apoptotic testicular, ovarian and uterine cells that indicating the severity of Profenofos toxicity. On the other hand, examined tissues of Profenofos in combination with selenium treated group showed apparent reduction of caspase-3 immunoreactivity to be more or less similar to the control group. In conclusion, selenium is a valuable cytoprotective which reduced the oxidative stress toxicity induced by Profenofos in the reproductive system of male and female as well as liver and kidney albino rabbits.

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Section: Effect Of Profenofos On Antioxidants Activitysupporting

confidence: 80%

Protecting Role of Selenium on the Cytotoxic Effect of Profenofos on Rabbit Fertility

Abdel-Rahman¹,

El-Metwally²,

El-Hallawany³

et al. 2017

AJVS

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show abstract

“…In this study, increase of TBARS level in brain is a result of LPO induction in this tissue. Liver is known as the most important target organ of metabolism and detoxification for many toxicants, whereas the brain may be particularly susceptible to oxidative damage because it contains a large amount of polyunsaturated fatty acids (Song et al 2006). In the previous study, it was found that brain was a more sensitive target organ to oxidative damage than liver (Song et al 2006;Zhang et al 2008).…”

Section: Discussionmentioning

confidence: 99%

The protective role of ascorbic acid (vitamin C) against chlorpyrifos-induced oxidative stress in Oreochromis niloticus

Özkan

Gündüz

Berköz

et al. 2011

Fish Physiol Biochem

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Ability of ascorbic acid (vitamin C) to attenuate oxidative damage was evaluated in liver and brain tissues of Oreochromis niloticus (O. niloticus) experimentally exposed to sublethal concentrations of chlorpyrifos (CPF). O. niloticus was exposed to sublethal concentrations of CPF at 12 μg/L (CPF1) and 24 μg/L (CPF2) for 96 h. The fish of vitamin C (Vit C) and CPF2 + Vit C groups were fed with Vit C supplemented diet (200 mg Vit C/100 g feed). A significant increase in thiobarbituric acid-reactive substances (TBARS) level (P < 0.05) was observed in brain of CPF-exposed fish although liver TBARS level was not changed compared to control group. This result showed that lipid peroxidation (LPO) was elevated in brain of fish exposed to CPF. Glutathione peroxidase (GSH-Px) activity in liver and brain tissues was significantly elevated (P < 0.05) by exposure to CPF1 and CPF2. Catalase (CAT) activity was significantly increased (P < 0.05) in liver but decreased in brain of treated fish by CPF2 concentration. Superoxide dismutase (SOD) activity was decreased in liver, but increased in brain by exposure to CPF1 and CPF2 concentrations. Levels of TBARS were increased in brain of CPF-treated animals, but tended to decrease by the effect of Vit C. Vit C treatment for CPF-intoxicated animals normalized the otherwise raised activities of GSH-Px, CAT, and SOD within normal limits. The results clearly indicate that exposure to CPF caused a dose-dependent increase in oxidative stress brain and to a lesser extend in liver of fish and the ability of Vit C to attenuate CPF-induced oxidative damage.

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“…On the contrary, antioxidant enzymes in liver show a higher activity than other organs in fish (Lemaire et al, 1994) indicating a high capacity to tolerate oxidative stress. Furthermore, in previous study, it was found that brain was a more sensitive target organ to oxidative damage than liver (Song et al, 2006). So, in this study, we selected the brain as an object of study.…”

Section: Discussionmentioning

confidence: 99%

Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD)

Zhang¹,

Yang²,

Xu³

et al. 2008

Aquatic Toxicology

144

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Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

Cited by 122 publications

References 41 publications

Protecting Role of Selenium on the Cytotoxic Effect of Profenofos on Rabbit Fertility

Protecting Role of Selenium on the Cytotoxic Effect of Profenofos on Rabbit Fertility

The protective role of ascorbic acid (vitamin C) against chlorpyrifos-induced oxidative stress in Oreochromis niloticus

Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD)

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