Effects of high frequency rTMS on sleep deprivation: A pilot study

Martínez-Cancino, D. P.; Azpiroz-Leehan, J.; Jiménez-Ángeles, Luis; Garcia-Quintanar, A.; Santana-Miranda, Rafael

doi:10.1109/embc.2016.7592080

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Few years later, the same research group showed the beneficial effects of rTMS after 4 sessions of concurrent rTMS/task performance given over the course of 2 days of SD ( Luber et al, 2013 ). Similar results were reported by other authors, with 5 Hz-rTMS over the left middle occipital gyrus, resulting in greater accuracy and shorter response times after SD ( Martinez-Cancino et al, 2016 ; Guo et al, 2019 ). Lastly, a recent study has evaluated the effect of high-frequency rTMS on reversing the negative effects of SD for 24 h in 66 healthy individuals randomized into “real” rTMS group and “sham” group ( Li et al, 2021 ).…”

Section: Resultssupporting

confidence: 91%

A comprehensive review of transcranial magnetic stimulation in secondary dementia

Lanza

Fisicaro

Dubbioso

et al. 2022

Front. Aging Neurosci.

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Although primary degenerative diseases are the main cause of dementia, a non-negligible proportion of patients is affected by a secondary and potentially treatable cognitive disorder. Therefore, diagnostic tools able to early identify and monitor them and to predict the response to treatment are needed. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological technique capable of evaluating in vivo and in “real time” the motor areas, the cortico-spinal tract, and the neurotransmission pathways in several neurological and neuropsychiatric disorders, including cognitive impairment and dementia. While consistent evidence has been accumulated for Alzheimer’s disease, other degenerative cognitive disorders, and vascular dementia, to date a comprehensive review of TMS studies available in other secondary dementias is lacking. These conditions include, among others, normal-pressure hydrocephalus, multiple sclerosis, celiac disease and other immunologically mediated diseases, as well as a number of inflammatory, infective, metabolic, toxic, nutritional, endocrine, sleep-related, and rare genetic disorders. Overall, we observed that, while in degenerative dementia neurophysiological alterations might mirror specific, and possibly primary, neuropathological changes (and hence be used as early biomarkers), this pathogenic link appears to be weaker for most secondary forms of dementia, in which neurotransmitter dysfunction is more likely related to a systemic or diffuse neural damage. In these cases, therefore, an effort toward the understanding of pathological mechanisms of cognitive impairment should be made, also by investigating the relationship between functional alterations of brain circuits and the specific mechanisms of neuronal damage triggered by the causative disease. Neurophysiologically, although no distinctive TMS pattern can be identified that might be used to predict the occurrence or progression of cognitive decline in a specific condition, some TMS-associated measures of cortical function and plasticity (such as the short-latency afferent inhibition, the short-interval intracortical inhibition, and the cortical silent period) might add useful information in most of secondary dementia, especially in combination with suggestive clinical features and other diagnostic tests. The possibility to detect dysfunctional cortical circuits, to monitor the disease course, to probe the response to treatment, and to design novel neuromodulatory interventions in secondary dementia still represents a gap in the literature that needs to be explored.

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Section: Resultssupporting

confidence: 91%

A comprehensive review of transcranial magnetic stimulation in secondary dementia

Lanza

Fisicaro

Dubbioso

et al. 2022

Front. Aging Neurosci.

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“…Previous rTMS studies on patients with cognition impairment in Alzheimer's disease, Parkinson's disease, schizophrenia, and dementia in older patients have reported significant positive effectiveness on improving cognitive ability [23][24][25][26]. Similar results were reported in both animal and human studies on SD which also observed the potential effectiveness of rTMS for the treatment of cognitive impairment induced by SD, especially the working memory [27][28][29][30][31]. One human study also observed the significant correlation between the cortical activation changes induced by SD and the enhanced working memory performance during rTMS over the identical cortical site.…”

Section: Introductionsupporting

confidence: 77%

“…Neural Plasticity parasagittal plane [33]. Numerous studies on the effect of SD on working memory, which used the N-back task, have found decreased activation mainly in the frontal lobe [27]. Studies with PET also have observed lower metabolism in prefrontal and parietal areas due to lack of sleep [34].…”

Section: Rtms Proceduresmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Jiang

McClure

et al. 2019

Neural Plasticity

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Objective. To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods. Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. The amplitude of low-frequency fluctuations (ALFF) was used to detect the spontaneous neural activity changes after both SD and rTMS. The relationship between ALFF and the performance of working memory was also assessed by using correlation analysis. Results. After SD, the participants exhibited lower response accuracies and longer reaction times on the working memory tests of letters and numbers. The decreased response accuracy of numbers was significantly improved after rTMS similarly to the state of the rested waking period after a normal night of sleep. ALFF values decreased from the rested waking period state to the state of SD in the brain regions involving the frontal gyrus, precuneus, angular gyrus, and parietal lobe which showed significantly increased ALFF after rTMS. Furthermore, significantly positive correlations were observed between changes of response accuracy and the changes of ALFF value of the inferior frontal gyrus and supramarginal gyrus. Conclusion. These results indicate that high-frequency rTMS applied over left DLPFC may contribute to the recovery of the impaired working memory after SD by modulating the neural activity of related brain regions.

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“…These Surprisingly, subjects' performance on the digit span task was better the morning after alcohol compared to placebo. This is inconsistent with reports that both acute alcohol and sleep deprivation impair working memory function (Alhola & Polo-Kantola, 2007;Frenda & Fenn, 2016;Martinez-Cancino et al, 2016;Mintzer, 2007;Scott Saults et al, 2007;Stevens et al, 2022). Yet, other studies either did not detect the effects of intoxication on next-day cognitive and behavioral performance (Rohsenow et al, 2006(Rohsenow et al, , 2010 or found nonsignificant improvements in performance (Howland et al, 2010b).…”

Section: Discussionmentioning

confidence: 80%

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

Pabon

Greenlund

Carter

et al. 2022

Alcoholism Clin & Exp Res

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Background: Alcohol consumption produces feelings of well-being and stimulation, but also impairs psychomotor performance, disturbs cardiovascular function and sleep, and can disrupt next-day mood and behavior. A deeper understanding of how the acute effects of alcohol relate to its sleep and morning-after effects is needed to minimize harm resulting from its use. This study examined relationships between the effects of a high dose of alcohol on subjective and psychomotor measures, nocturnal heart rate, sleep quality, and morning-after mood and behavior. We hypothesized that alcohol would produce disturbances in cardiovascular and sleep regulation during the night, which would predict morning-after mood and behavioral performance.Methods: Thirty-one men and women participated in two overnight laboratory visits during which they consumed either alcohol (1.0 g/kg for men, 0.85 g/kg for women) or placebo (randomized, crossover design). They consumed the beverage from 8 to 9 pm, and remained in the laboratory overnight for polysomnographic sleep recording.Subjective and behavioral measures were obtained during consumption and at 7-8 am the morning after.Results: Alcohol increased both negative and positive arousal, urge to drink and sedation, and it impaired performance on behavioral tasks. During sleep, alcohol produced expected tachycardia and detriments in sleep quality including decreased total sleep time, sleep efficiency, and altered sleep architecture. Only modest effects on mood or performance were detected the following morning. The acute sedative-like effects of alcohol were related to increases in N2 sleep, but not to other disruptions in sleep or nocturnal heart rate, and neither sleep impairments nor nocturnal heart rate were related to mood or task performance the morning after. Conclusions:The effects of alcohol on sleep and nocturnal heart rate were not strongly related to either its acute or morning-after effects. These findings do not provide strong support for the idea that alcohol-induced sleep disruptions underlie morning-after effects.

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Effects of high frequency rTMS on sleep deprivation: A pilot study

Cited by 6 publications

References 9 publications

A comprehensive review of transcranial magnetic stimulation in secondary dementia

A comprehensive review of transcranial magnetic stimulation in secondary dementia

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

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