Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease

Abstract

Background: Some studies assessed the effect of aerobic exercise on diabetic obese patients with hepatic disease, while very limited studies compared high-intensity interval (HII) versus moderate-intensity continuous (MIC) on diabetic obese patients with non-alcoholic fatty liver disease (NAFLD). Objectives: This study was designed to assess the effects of HII versus MIC on intrahepatic triglycerides (IHTG) and visceral lipids in diabetic obese patients with NAFLD. Design: Randomized controlled trial. Methods: Forty-seven diabetic obese individuals with NAFLD were enrolled in this study. The individuals were randomly divided into 16 in HII group, 15 in MIC group, and 16 in the controls. HII group received HII exercise, MIC group received 8-week MIC exercise while the control group did not receive any exercise intervention. IHTG and visceral lipids were assessed pre- and post-intervention. Results: Baseline and clinical characteristics showed nonsignificant difference among the 3 groups ( P > .05). Both HII and MIC groups showed a significant reduction in hepatic fat and visceral lipids ( P < .05), while the controls showed nonsignificant difference ( P > .05) after completing the study intervention. Postintervention analysis showed nonsignificant changes between the HII and MIC groups ( P > .05). Conclusions: Exercise training wither HII or MIC aerobic exercise reduces IHGT and visceral lipids in diabetic obese patients with NAFLD. No differences were observed between the effects of both exercise programs on diabetic obese patients with NAFLD.

[Retracted] Effect of Moderate‐Intensity Aerobic Exercise on Hepatic Fat Content and Visceral Lipids in Hepatic Patients with Diabesity: A Single‐Blinded Randomised Controlled Trial

“…Moreover, prior studies verified that 50-60 minutes of daily aerobic exercise for 4 weeks (beginning with 60-65% max HR and ending by 80-85% max HR) resulted in improvement of insulin sensitivity, glucose oxidation, and visceral lipids [34]. Similarly, Abdelbasset et al approved that cycling exercise with 80% to 85% VO 2max and interval at 50% VO 2max for 40 minutes 3 times weekly for eight weeks showed a fluent decrease of hepatic triglycerides, visceral fats, and insulin resistance in diabetic obese patients with NAFLD [35,36].…”

Effect of exercise on hepatic steatosis: Are benefits seen without dietary intervention? A systematic review and meta‐analysis

“…Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HDL-C, high-density lipoprotein cholesterol; LDL-C, lowdensity lipoprotein cholesterol; H, no; TG, triglycerides; VO 2 peak, peak volume oxygen consumption; Y, yes. 10 studies 11,12,14,[20][21][22][23][24][25][26] instructed participants to maintain their habitual diets, and nine studies 12,14,17,22,[24][25][26][27][28] recorded subject food intake. As shown in Figure 3, the effect of exercise on body weight was found to be significant, where a mean reduction of 1.07 kg occurred (95% CI: −1.57 to −.58 kg), equating with a 1.5% reduction in body weight.…”

Statement of Concern

“…The journal was alerted to concerns alleging improper statistical analysis in published article “Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease” [ 1 ] which appeared in Volume 99, Issue 10 of Medicine . After investigation, it was found that the analysis performed was inappropriate and as a result, the data must be re-analyzed and corrected appropriately.…”

“…Additionally, a concern was raised regarding potential duplication of results in [ 1 ] that were reported in [ 2 ] and “Effect of Moderate-Intensity Aerobic Exercise on Hepatic Fat Content and Visceral Lipids in Hepatic Patients with Diabesity: A Single-Blinded Randomised Controlled Trial” [ 3 ] which appeared in Volume 2020 of Evidence-Based Complementary and Alternative Medicine . After investigation, it appears duplication did not occur as [ 1 ] presents an experimental arm (MICT), although authors appear to have failed to include deviations to experimental arms in the clinical trial registration.…”