Li 2 TiO 3 is considered as one of the best candidates for breeding materials. This article adopted a modification water-based sol-gel method to synthesize nano-Li 2 TiO 3 powders, which overcomes the poor phase purity, coarse grain, and inferior crushing strength described in the previous literature. In this paper, the thermal effect of the precursor, the crystal phase, and the morphology of the powders were characterized by thermogravimetric analysis/differential thermal analysis (TG/DTA), X-ray diffraction (XRD), and transmission electron microscopy (TEM) techniques. The nano-structured Li 2 TiO 3 powders with good dispersion and an average particle size of 20-50 nm were successfully synthesized at 600 • C by controlling PH and hydrolysis rate. Moreover, the phase transition temperature for the monoclinic phase β-Li 2 TiO 3 was as low as 600 • C, which is lower than 750 • C using the traditional solid-state method. Meanwhile, the morphology, porosity, crushing load, and thermal conductivity of ceramic pebbles are characterized systematically by using scanning electron microscope (SEM), mercury injection meter, compression strength equipment, and laser scattering method, respectively. Experimental results showed that the Li 2 TiO 3 ceramic pebbles with a sphericity of .98, crush load of 48.4 N, and relative density of 90.03 % were successfully prepared at 1050 • C for 2 h. This method will provide new guidance for the preparation of tritium breeders.