Effects of high voltage pulsed current stimulation with a visible contraction intensity on expression of TGF-β1 and synthesis of type I collagen in wound-induced white rats

Jeon, Jae-Keun; Park, Seung-Kyu; Lee, Joon‐Hee

doi:10.1589/jpts.27.1485

Cited by 13 publications

(9 citation statements)

References 27 publications

(28 reference statements)

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“…Jeon et al . 36 observed that the use of a high-voltage pulsed current led to improved contraction and promoted healing in the skin wounds of rats by increasing the expression of transforming growth factor β1 (TGF-β1) and type 1 collagen synthesis.…”

Section: Discussionmentioning

confidence: 99%

Histological evaluation of the effect of low-frequency electric stimulation on healing Achilles tendons in rats

et al. 2021

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Purpose: Histologically evaluate the effects of low frequency electrical stimulation in the treatment of Achilles tendon injuries in rats. Methods: Thirty-four rats underwent Achilles tendon tenotomy and tenorrhaphy. They were randomly allocated in two groups. Half of the sample constituted the experiment group, whose lesions were stimulated with 2 Hz, nonpolarized current and 1 mA, for 14 days. The other animals formed the control group. They were evaluated at 2, 4 and 6 weeks. The histological study was carried out, the collagen density and the wound maturity index were measured. Results: The healing score was higher in the group stimulated at the 6th week (p = 0.018). The density collagen 1 was higher in the group treated at the three times (p = 0.004) and that collagen 3 was higher in the group treated at 6 weeks (p = 0.004). Together, collagen 1 and 3 were higher in the group stimulated at 4 and 6 weeks (p = 0.009, p = 0.004). The maturity index was higher in this group at the three moments (p = 0.017 p = 0.004 and p = 0.009). Conclusion: Low frequency electric stimulation improved healing and increased the quantity of collagen.

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Section: Discussionmentioning

confidence: 99%

Histological evaluation of the effect of low-frequency electric stimulation on healing Achilles tendons in rats

et al. 2021

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“…HVPC has been used in peripheral neurological deficits and vascular and chronic pressure cutaneous ulcer treatments because it speeds up the healing process represented by smaller, better-looking lesions 14 - 18 . Jeon et al 19 observed that HVPC with visible contraction intensity was effective in promoting wound healing by increasing expression of transforming growth factor β1(TGF-β1) and synthesis of type I collagen. Furthermore, HVPC has been an effective method for minimizing the severity of repetitive stress injuries of the wrist (pain and edema levels decreased and grip strength and the range of motion increased) 20 .…”

Section: Discussionmentioning

confidence: 99%

High voltage pulsed current in collagen realignment, synthesis, and angiogenesis after Achilles tendon partial rupture

Rampazo

Liebano

Pinfildi

et al. 2016

Braz. J. Phys. Ther.

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ObjectiveTo verify the efficacy of high voltage pulsed current in collagen realignment and synthesis and in angiogenesis after the partial rupturing of the Achilles tendon in rats.MethodForty male Wistar rats were randomized into four groups of 10 animals each: sham, cathodic stimulation, anodic stimulation, and alternating stimulation. Their Achilles tendons were submitted to direct trauma by a free-falling metal bar. Then, the treatment was administered for six consecutive days after the injury. In the simulation group, the electrodes were positioned on the animal, but the device remained off for 30 minutes. The other groups used a frequency of 120 pps, sensory threshold, and the corresponding polarity. On the seventh day, the tendons were removed and sent for histological slide preparation for birefringence and Picrosirius Red analysis and for blood vessel quantification.ResultsNo significant difference was observed among the groups regarding collagen realignment (types I or III collagen) or quantity of blood vessels.ConclusionHigh voltage pulsed current for six consecutive days was not effective in collagen realignment, synthesis, or angiogenesis after the partial rupturing of the Achilles tendon in rats.

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“…The diameter of the ulcers were measured with the naked eyes using a digital stainless vernier caliper which is capable of measuring diameter in 0.05 mm increments. 14,15 All measurements were performed by the same operator.…”

Section: Clinical Evaluationmentioning

confidence: 99%

Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel

2021

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Background: Areca nut (Areca catechu Linn.) is the seed of the fruit of the oriental palm that is commonly used among Southeast Asian communities. Chrysanthemum (Dendrathema grandiflora) is a flowering plant originating from East Asia and dominantly grows in China. Both of these plants have strong antioxidant activities. To investigate the mechanism of their wound healing activities, we prepared areca nut and chrysanthemum polyethylene oral gel and performed several in vivo assays using Sprague–Dawley rats. Methods: Sprague–Dawley rats were divided into five groups: Negative control group (rats with base gel treatment), positive control group (rats treated with triamcinolone acetonide), F1 (treatment with 20% areca nut:80% chrysanthemum), F2 (treatment with 50% areca nut:50% chrysanthemum), and F3 (treatment with 80% areca nut:20% chrysanthemum). Traumatic ulcers were performed on the buccal mucosa of all experimental animals that received topical oral gel and triamcinolone acetonide twice a day for seven days. The clinical and histological characteristics were analyzed and scored. Results: During the six days, the ulcerated area receded linearly over time and was completely cicatrized in F2 and positive control group (Dependent t-test, p<0.05). There were significant increases in body weight in F2 and positive control groups. There were no significant differences between groups in histology examination (Kruskal Wallis test, p<0.05). The moderate score of TNF-α levels was seen in F2 and positive control groups (ANOVA/Tukey test). Similar results were seen in the collagenases assay. Conclusions: A balanced combination of areca nut and chrysanthemum extract in the oral gel can optimize the healing of traumatic oral ulcers in rats through the increase of TNF-α and collagen deposition.

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Effects of high voltage pulsed current stimulation with a visible contraction intensity on expression of TGF-β1 and synthesis of type I collagen in wound-induced white rats

Cited by 13 publications

References 27 publications

Histological evaluation of the effect of low-frequency electric stimulation on healing Achilles tendons in rats

Histological evaluation of the effect of low-frequency electric stimulation on healing Achilles tendons in rats

High voltage pulsed current in collagen realignment, synthesis, and angiogenesis after Achilles tendon partial rupture

Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel

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