Effects of Higher Levels of Zinc Supplementation on Performance, Mineral Availability, and Immune Competence in Broiler Chickens

Sunder, G. Shyam; Panda, A.K.; Gopinath, N. C. S.; Rao, S.V. Rama; Raju, M.V.L.N.; Reddy, M. R.; Kumar, Ch. Vijay

doi:10.3382/japr.2007-00029

Cited by 130 publications

(103 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study the expression of IL-2 gene increased in Thr or Met+Cys treatment, possibly related to the cell-mediated immunity (Kidd et al 1996;Shyam Sunder et al 2008). In earlier studies significant difference in cell mediated immunity was observed in in ovo injection of AA combinations containing Lys, Thr or Met+Cys (Bhanja and Mandal 2005;Bakyaraj et al 2012) and they also increased the relative weight of spleen .…”

Section: Il-4 Il-6 Tnfαmentioning

confidence: 73%

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Bhanja¹,

Sudhagar²,

Goel³

et al. 2014

CZECH J ANIM SCI

View full text Add to dashboard Cite

The present study was aimed at investigating the role of in ovo administered amino acids: lysine, arginine, threonine or methionine plus cysteine (Met+Cys) in 14-day embryos on expression profile of growth (chicken growth hormone (cGH), insulin like growth factors (IGF) I and II, and mucin) and immunity related genes (IL-2, IL-4, . On incubation day (ID) 18, higher (P < 0.01) cGH and mucin gene expression was observed in lysine, threonine, arginine or Met+Cys injected embryos, while IGF-II expression was higher in threonine, arginine or Met+Cys injected embryos on ID 20. Expression of growth genes was down regulated (P < 0.01) on day of hatch in most of the amino acids injected chicks. On day 7 post-hatch (PH), threonine or arginine exhibited higher expression of cGH, IGF-I, and IGF-II but higher mucin gene expression only on day 14 PH. Threonine or Met+Cys injected birds had higher expression of IL-6 and TNF-α, while arginine injected birds had higher TNF-α expression. Lysine, threonine or Met+Cys injected birds had higher IL-2, but lower of IL-12 and IFN-γ gene expression. It is concluded that arginine and threonine enhanced the expression of growth related genes, while threonine and Met+Cys modulated expression of immune genes in broiler chickens.

show abstract

Section: Il-4 Il-6 Tnfαmentioning

confidence: 73%

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Bhanja¹,

Sudhagar²,

Goel³

et al. 2014

CZECH J ANIM SCI

View full text Add to dashboard Cite

show abstract

“…Similarly, Zn supplementation resulted in an increased level of sIgA in the intestinal flush. Sunder et al (2008) observed the highest antibody titer (diet supplemented with Zn at 10, 20, 40, 80, 160 and 320 ppm) after inoculation of nonpathogenic antigen in chicken fed 80 ppm of Zn. The authors in the evaluation of cellular immune response to inoculation of nonpathogenic antigen did not find statistically different response from 20 to 160 ppm Zn levels in the feed.…”

Section: Discussionmentioning

confidence: 87%

“…National Research Council (1994) recommended 40 ppm for broiler chickens, which appeared to be based on the results that considered growth performance as the only criterion (Burrell et al, 2004;Sunder et al, 2008). However, there are several reports that demonstrate that higher Zn levels (60-180 ppm) produce better immune status in broiler chickens (Feng et al, 2010;Tang, Wen, Li, Wang, & Zhou, 2014).…”

Section: Introductionmentioning

confidence: 99%

Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-β4 gene expression and sIgA secretion in broiler chickens

Levkut

Husáková

Bobíková

et al. 2017

Food and Agricultural Immunology

View full text Add to dashboard Cite

The study compared the effect of dietary supplementation with an inorganic or organic source of zinc (Zn) on mucin 2 (MUC-2) and IgA gene expression, the cytokines IL-17 and TGF-β4 and the secretory IgA content (sIgA) in broiler jejunum. One-day-old chickens were fed an unsupplemented basal diet (BD) or the same BD supplemented with 30 or 70 mg/kg of added Zn from ZnSO 4 ·H 2 O or Zn chelate of glycine hydrate for 40 days. The highly expressed MUC-2 and IgA genes were observed in both groups supplemented with the low-dose Zn sources (30 mg/kg). A higher sIgA concentration was observed in both the ZnSO 4 groups and the glycine-zinc/30 mg group. Our data indicate that the organic Zn chelate has better availability than the inorganic Zn source, and the low-dose Zn diets proved to be more beneficial to the maintenance of intestinal immune homeostasis. ARTICLE HISTORY

show abstract

“…Supplementation of Zn in diets also improves intestinal morphology by increasing the villus height and reducing the crypt depth in animals [4,10]. criterion [5,12]. However, there are several reports that demonstrate that higher Zn levels [60-180 ppm] produce better immune growth performance and intestinal function of broiler chickens [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

et al. 2017

View full text Add to dashboard Cite

show abstract

Effects of Higher Levels of Zinc Supplementation on Performance, Mineral Availability, and Immune Competence in Broiler Chickens

Cited by 130 publications

References 17 publications

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-β4 gene expression and sIgA secretion in broiler chickens

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

Contact Info

Product

Resources

About