Effects of hippocampal lesions on maze learning and retention in rats

Kaada, B; Rasmussen, E. Wulff; Kveim, O

doi:10.1016/0014-4886(61)90009-7

Cited by 124 publications

(35 citation statements)

References 17 publications

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“…The present data and those of Neocortical a previous study (Niki, 1965) suggest that hippocampal ablation would reduce the response inhibition, and therefore would produce the tendency for the animal to perseverate. There is some possibility that the suggested perseverative tendency (one of the manifestations of inhibitory deficits) in the present experiments could explain some of the previous reports on learning deficits following the hippocampal ablation (Thomas & Otis, 1958;Orbach et al, 1960;Stepien et al, 1960;Kaada et al, 1961;Niki, 1962Niki, , 1965Kimble, 1963;Kveim et al, 1964).…”

Section: Discussionmentioning

confidence: 52%

Response Perseveration Following the Hippocampal Ablation in the Rat

Niki

1966

Jpn. Psychol. Res

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Section: Discussionmentioning

confidence: 52%

Response Perseveration Following the Hippocampal Ablation in the Rat

Niki

1966

Jpn. Psychol. Res

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“…It is mainly well-known for its contribution to spatial learning and memory (both in rats, e.g., [75], and in humans, e.g., [107]), in particular, explicit memory (e.g., [152]). Its role in inhibitory processes has also been emphasized (e.g., [28]).…”

Section: The Anterior Medial Temporal Lobes -Classical Rolementioning

confidence: 99%

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Coppin

2016

Physiology & Behavior

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• The amygdala and hippocampus play a major role in food intake and weight regulation.• These functions are far less known to cognitive and affective scientists.• This review uniquely expands on the interactions between these two brain structures. a b s t r a c t a r t i c l e i n f o The anterior medial temporal lobes are one of the most studied parts of the brain. Classically, their two main structures -the amygdalae and the hippocampi -have been linked to key cognitive and affective functions, related in particular to learning and memory. Based on abundant evidence, we will argue for an alternative but complementary point of view: they may also play a major role in food intake and body weight regulation. First, an overview is given of early clinical evidence in this line of thought. Subsequently, empirical evidence is presented on how food intake, including in the extreme case of obesity, may relate to amygdalian and hippocampal functioning. The focus is on the amygdala's role in processing the relevance of food stimuli, cue-induced feeding, and stress-induced eating and on the hippocampus' involvement in the use of interoceptive signals of hunger and satiety, as well as memory and inhibitory processes related to food intake. Additionally, an elaboration takes place on possible reciprocal links between food intake, body weight, and amygdala and hippocampus functioning. Finally, issues that seemed particularly critical for future research in the field are discussed.

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“…In addition to lesion locus, the nature of the passive avoidance task used (Snyder & Isaacson, 1965) and the amount of pretraining (Isaacson et al, 1966;Kimble et al, 1966) appear to be important variables in the degree of passive avoidance impa~r-ment that is found after hippocampectomy. Hippocampal lesions have also been shown to facilitate the acquisition of an active avoidance response (Isaacson et al, 1961). o Hippocampal animaIs have been found to persist in loco-6 motor activity wh en it is measured in large chambers (Douglas & Isaacson, 1964;Teitelbaum & Milner, 1963), mazes (Roberts et al, 1962), and exploratory boxes (Kaplan, 1966) but not when measured in small chambers (Kim, 1960) or running wheels (Kaada et al, 1961;Leaton, 1963). Kaplan (1966) has suggested that conditions which enhance Ifapproach" or exploratory behavior appear to be more likely to produce prolonged activity in hippocampectomized animaIs.…”

Section: Hippocampusmentioning

confidence: 99%

Amygdaloid lesions and behavioral inhibition in the rat.

Pellegrino¹

1968

Journal of Comparative and Physiological Psychology

135

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Rats with bilateral lesions of the basolateral region of the amygdala were impaired in passive avoidance, DRL performance, and spatial alternations without cues, but not in visually cued spatial alternations or go-no-go visual discriminations and reversals. Except for a small deficit in passive avoidance, rats with lesions in the corticomedial region of the amygdala were not impaired in these tasks. Deficits produced by basolateral lesions can not readily be attributed to increased motivation for food or water. Results suggest that rats with basolateral amygdaloid lesions are unable to inhibit established responses when they must depend on information provided by internal cues.1 This report is based on a dissertation submitted to McGill University in partial fulfillment of the requirements for the PhD degree. The author wishes to thank his thesis adviser, R. B.

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Effects of hippocampal lesions on maze learning and retention in rats

Cited by 124 publications

References 17 publications

Response Perseveration Following the Hippocampal Ablation in the Rat

Response Perseveration Following the Hippocampal Ablation in the Rat

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Amygdaloid lesions and behavioral inhibition in the rat.

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