Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System)

Abstract

Background/AimsThe effects of Histamine-2 receptor antagonists and proton pump inhibitors on the gastrointestinal motility have not yet been sufficiently investigated. The aim of this study was to determine the effects of intravenous bolus administration of famotidine and omeprazole on the rate of gastric emptying using the continuous 13C breath test (BreathID system, Exalenz Bioscience Ltd, Israel).MethodsTwelve healthy male volunteers participated in this randomized, 3-way crossover study. After fasting overnight, the subjects were randomly assigned to receive 20 mg of famotidine, 20 mg of omeprazole or 20 mL of saline alone by intravenous bolus injection before a test meal (200 kcal per 200 mL, containing 100 mg of 13C-acetate). Gastric emptying was monitored for 4 hours after the ingestion of test meal by the 13C-acetic acid breath test performed using the BreathID system.ResultsNo significant differences in the calculated parameters, namely, the T1/2, Tlag, GEC, β and κ, were observed among the 3 test conditions.ConclusionsThe study revealed that intravenous administration of gastric acid suppressant drugs had no significant influence on the rate of gastric emptying in comparison with that of saline alone as a placebo. Our results indicating the absence of any effect of either famotidine or omeprazole on accelerating the rate of gastric emptying suggest that both medications can be administered safely to patients suffering from hemorrhagic peptic ulcers who need to be kept nil by mouth from the viewpoint of possible acceleration of gastrointestinal motility in the clinical setting.

Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)

“…It also decreases the examination time and alleviates patient discomfort. Continuous analysis also provides quick, immediate results (20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

“…The two test were separated by a washout period of at least 7 days. In both of the experiments, the tests were started after the patients had fasted overnight (at least 8 hours), and the breath test was performed while the subjects were seated for 4 hours (20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

“…Subjects participating in experiment B took the breath test after meal intake. Breath samples were continuously collected via a nasal tube using the BreathID system (Exalenz Bioscience Ltd., Israel) at baseline before the test meal and following the completion of test meal ingestion (time 0) for up to 4 hours (20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

“…[23][24][25][26][27] PPI induced the delay of gastric emptying in solid food, but there was few literature about prevention of the treatment delayed gastric emptying, and evaluations on dyspeptic symptoms. 8,[28][29][30] Tegaserod (5-HT4 receptor agonist) was used to normalize the delayed gastric empting caused by PPIs in previous study, but tegaserod is out of market from its cardiovascular risk, so there is no proven safe drug which was studied for preventing the PPI induce delayed gastric emptying. In present study, the efficacy of mosapride citrate for preventing the PPI induced gastric emptying was assessed.…”

Do Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Really Have No Effect on the Gastric Emptying Rate?: Author's Reply

“…"2 As they pointed out, many studies have been conducted to exam the effects of gastric acid suppressants on gastric emptying, however, results from those studies have been controversial. Our study using liquid meals revealed that intravenous administration of gastric acid suppressants had no significant influence on the rate of gastric emptying.…”