Effects of histamine and related compounds on the release of immunoreactive thyrotropin-releasing hormone from the rat stomach in vitro

Mitsuma, Terunori; Sun, De Heng; Nogimori, T; Chaya, Masahiro; Ohtake, Kozaburo; Hirooka, Y

doi:10.1016/0196-9781(87)90012-x

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Mitsuma et al [21] have earlier reported that serotonin stimulated ir-TRH release from the rat stomach in vitro, which agrees with the present study. Both endogenous and exoge nous serotonin has been proposed to be closely related to gastric mucosal damage without increase in the gastric acid output [23] , in agreement with the present study.…”

Section: 22]supporting

confidence: 83%

“…It is well known that GR38032F is effective in the pro phylaxis of emesis induced by chemotherapy [24] , while cyproheptadine, whose effects on ir-TRH concentrations of the rat stomach in vitro were previously reported [21], is presently used in patients with dumping syn drome [25]. In the present study, the effects of serotonin on ir-TRH concentrations were sig nificantly blocked by cyproheptadine or GR38032F pretreatment.…”

Section: 22]supporting

confidence: 52%

“…The question can be raised as to whether the increase in ir-TRH concentrations of gastric juice might be due to contamination from the blood. However, the concentrations of gastric juice ir-TRH were much higher than those in plasma [7], and no macroscopic mucosal damage was observed within 60 min after se rotonin injection. On the other hand, the sero tonin concentration of the stomach wall in creased significantly at 15 min after serotonin injection and rapidly decreased over 30 min, then the peak change in ir-TRH concentra tion of the stomach wall was identical to that of the serotonin concentration in the stomach wall.…”

Section: 22]mentioning

confidence: 98%

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Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Kaneko

Mitsuma²,

Morise³

et al. 1992

Digestion

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The effects of serotonin and its related compounds on immunoreactive thyrotropin-releasing hormone (ir-TRH) concentrations of the rat stomach wall and gastric juice were studied. Either serotonin, cyproheptadine or GR38032F was injected intraperitoneally, and the rats were decapitated at various times after the injection. ir-TRH concentrations of the stomach wall and gastric juice were measured by radioimmunoassay, and gastric serotonin concentrations were measured by HPLC. ir-TRH concentrations of the stomach wall decreased, and ir-TRH concentrations of gastric juice increased significantly after serotonin injection. On the other hand, both cyproheptadine and GR38032F did not affect ir-TRH concentrations of the stomach. The effects of serotonin on ir-TRH concentrations of the stomach were significantly blocked by the pretreatment of cyproheptadine and GR38032F. The reciprocal changes of gastric ir-TRH and serotonin concentrations were observed without changes in gastric juice pH. These findings suggest that serotonin stimulates ir-TRH release from the stomach wall into gastric juice, and the effects of serotonin on ir-TRH release may be partly mediated via 5-HT₂- and 5-HT₃-receptors.

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Section: 22]supporting

confidence: 83%

Section: 22]supporting

confidence: 52%

Section: 22]mentioning

confidence: 98%

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Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Kaneko

Mitsuma²,

Morise³

et al. 1992

Digestion

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“…Acetylcholine does not affect TRH release from the rat hypothalamus (Joseph-Bravo et al, 1979). The authors previously reported that acetylcholine stimulated TRH release from the rat stomach and the rat caecum (Mitsuma et al, 1987;Mitsuma et al, 1989). Thus, previous reports and present data taken together suggest that the cholinergic system stimulates TRH release from the rat retina, and that TRH in the rat retina may modulate retinal function, and that the effect of the cholinergic system on TRH release differs from organ to organ.…”

Section: Discussionsupporting

confidence: 60%

Effects of Acetylcholine on the Release of Thyrotropin-Releasing Hormone from the Rat Retina in vitro

Mitsuma

Hirooka²,

Kayama³

et al. 2009

Exp Clin Endocrinol Diabetes

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Effects of acetylcholine on the release of thyrotropin-releasing hormone (TRH) from the rat retina were studied in vitro. The retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium) for 20 min. The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was enhanced significantly in a dose-related manner with the addition of acetylcholine and inhibited with addition of atropine. The stimulatory effect of acetylcholine on TRH release from the retina was blocked with the addition of atropine. The elution profile of methanol-extract of the rat retina was identical to that of synthetic TRH. The findings suggest that the cholinergic system stimulates TRH release from the rat stomach in vitro.

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Peptide and Protein Hormones

König

2000

Ullmann's Encyclopedia of Industrial Chemistry

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Effects of histamine and related compounds on the release of immunoreactive thyrotropin-releasing hormone from the rat stomach in vitro

Cited by 9 publications

References 11 publications

Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Effects of Acetylcholine on the Release of Thyrotropin-Releasing Hormone from the Rat Retina in vitro

Peptide and Protein Hormones

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