Effects of histamine H1 receptor antagonists on delayed spatial win-shift task in rats

Okada, Akiko; Kato, Akane; Kamei, Chiaki

doi:10.1016/j.ejphar.2010.01.005

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Moreover, errors made in the test phase were primarily caused by retrieval impairments as indicated by a higher ratio of across-phase errors in comparison to within-phase errors, confirming earlier studies (e.g. [40], [41]). Nonetheless, our findings reveal a basic ability of both strains to use previously acquired information after a temporal delay of either 30 s or 15 min.…”

Section: Discussionsupporting

confidence: 88%

Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

et al. 2013

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Disturbances in cognitive functioning are among the most debilitating problems experienced by patients with major depression. Investigations of these deficits in animals help to extend and refine our understanding of human emotional disorder, while at the same time providing valid tools to study higher executive functions in animals. We employ the “learned helplessness” genetic rat model of depression in studying working memory using an eight arm radial maze procedure with temporal delay. This so-called delayed spatial win-shift task consists of three phases, training, delay and test, requiring rats to hold information on-line across a retention interval and making choices based on this information in the test phase. According to a 2×2 factorial design, working memory performance of thirty-one congenitally helpless (cLH) and non-helpless (cNLH) rats was tested on eighteen trials, additionally imposing two different delay durations, 30 s and 15 min, respectively. While not observing a general cognitive deficit in cLH rats, the delay length greatly influenced maze performance. Notably, performance was most impaired in cLH rats tested with the shorter 30 s delay, suggesting a stress-related disruption of attentional processes in rats that are more sensitive to stress. Our study provides direct animal homologues of clinically important measures in human research, and contributes to the non-invasive assessment of cognitive deficits associated with depression.

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Section: Discussionsupporting

confidence: 88%

Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

et al. 2013

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“…The entire apparatus was surrounded by a 24.5 cm high transparent wall and elevated 43 cm above floor level. Furthermore, the apparatus was surrounded by various extra-maze cues, including a screen, a brightly colored poster, and a clock [46]. This test involved a training and a test phase.…”

Section: The Radial Maze Testmentioning

confidence: 99%

“…During this phase, all eight arms were opened and previously blocked arms were baited with grain pellets. A rat was placed inside the maze and the number of arm entries was recorded [46]. Before surgery, rats were habituated to the maze for 3 days.…”

Section: The Radial Maze Testmentioning

confidence: 99%

“…After surgery, testing was performed 1 day after infarction and then, monthly for 3 months. The rats acquired information on maze arms during the training phase, retained this information during the intervening period, and recalled it during the test phase [46]. Numbers and durations of arm entries were recorded by computerized monitoring.…”

Section: The Radial Maze Testmentioning

confidence: 99%

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Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion

Mankhong

Kim

Moon

et al. 2020

IJMS

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Although Alzheimer’s disease (AD)-like pathology is frequently found in patients with post-stroke dementia, little is known about the effects of aerobic exercise on the modifications of tau and related proteins. Therefore, we evaluated the effects of aerobic exercise on the phosphorylation and acetylation of tau and the expressions of tau-related proteins, after middle cerebral artery occlusion (MCAO) stroke. Twenty-four Sprague–Dawley rats with MCAO infarction were used in this study. The rehabilitation group (RG) received treadmill training 40 min/day for 12 weeks, whereas the sedentary group (SG) did not receive any type of training. Functional tests, such as the single pellet reaching task, rotarod, and radial arm maze tests, were performed monthly for 3 months. In ipsilateral cortices in the RG and SG groups, level of Ac-tau was lower in the RG, whereas levels of p-tauS396, p-tauS262, and p-tauS202/T205 were not significantly lower in the RG. Level of phosphorylated glycogen synthase kinase 3-beta Tyr 216 (p-GSK3βY216) was lower in the RG, but levels of p-AMPK and phosphorylated glycogen synthase kinase 3-beta Ser 9 (p-GSK3βS9) were not significantly lower. Levels of COX-2 and BDNF were not significantly different between the two groups, while SIRT1 significantly decreased in ipsilateral cortices in RG. In addition, aerobic training also improved motor, balance, and memory functions. Rehabilitation with aerobic exercise inhibited tau modification, especially tau acetylation, following infarction in the rat MCAO model, which was accompanied with the improvement of motor and cognitive functions.

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Nicotine increases behavioral variability on radial arm maze extinction. A preliminary study

Suarez

Solano

Barrios

et al. 2021

Learning and Motivation

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Effects of histamine H1 receptor antagonists on delayed spatial win-shift task in rats

Cited by 5 publications

References 14 publications

Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion

Nicotine increases behavioral variability on radial arm maze extinction. A preliminary study

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