Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: four-year follow-up from the ancillary skin study of the Kronos Early Estrogen Prevention Study

Owen, C.M.; Pal, Lubna; Freeman, Ruth; Isaac, Barbara; McDonald, Linda L.; Santoro, Nanette; Taylor, Hugh S.; Wolff, E

doi:10.1016/j.fertnstert.2016.06.023

Cited by 25 publications

(34 citation statements)

References 19 publications

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“…Through this literature search and discussion, we gathered eight articles on the aesthetic benefits of estrogen replacement, six articles on the anti‐aging benefits of topical estrogens, one article on the benefits of progesterone replacement, two articles on the benefit of testosterone replacement, one article on the benefit of oral DHEA replacement, four articles on the benefits of topical DHEA, and one article on the benefits of HGH replacement …”

Section: Methodsmentioning

confidence: 99%

“…These studies, however, often have limitations due to study design and/or sample population. In a study by Owen et al ., 116 postmenopausal women were randomized to treatment with 0.45 mg oral CEE or transdermal estradiol (50 μg daily), both with micronized progesterone (200 mg daily), or placebo for 4 years. In this study, HRT failed to demonstrate an improvement in skin wrinkling, by clinical assessment, and rigidity, by durometer.…”

Section: Hormonal Replacement and Skin Benefitsmentioning

confidence: 99%

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The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

et al. 2019

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The changes in skin and overall appearance that occur with increasing age can be partly attributed to declining hormone levels. While hormonal deficiencies are most commonly associated with postmenopausal females, males are also subject to age-related testosterone decline and may benefit from replacement of deficient hormones. However, great disparities exist between the recommendations of scientific societies and actual use of hormone supplements in aging patients. The purpose of this literature review is to discuss the role of hormones in the aging process of the skin, explain the safety profile of hormone replacement therapy, specifically discussing the superiority of bioidentical hormones, and highlight the benefits of hormone replacement in anti-aging of the skin. In summary, this literature review suggests that hormone replacement with bioidentical hormones is a safe and effective way to prevent skin aging.

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Section: Methodsmentioning

confidence: 99%

Section: Hormonal Replacement and Skin Benefitsmentioning

confidence: 99%

The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

et al. 2019

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“…These extrinsic factors have been shown to contribute to skin aging through oxidative stress, negatively impacting cellular processes including DNA replication, for example 1‐3 . Glycation, which favors oxidation 4 and the pathophysiological changes during menopause that result from a reduction in estrogen levels, also contribute to skin aging 5 . Principal health concerns of menopausal women include vasomotor symptoms, urogenital atrophy, osteoporosis, cardiovascular disease, cancer, psychiatric symptoms, cognitive decline, and sexual problems.…”

Section: Factors Influencing Skin Agingmentioning

confidence: 99%

Low molecular weight heparan sulfate containing facial skin care for reducing inflammation and restoring aged‐skin homeostasis

Bucay¹,

Gold

Andriessen³

2020

J of Cosmetic Dermatology

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Background Chronic exposure of the skin to environmental factors, including solar radiation and air pollution, promotes skin aging by inducing inflammation which damages the skin. Heparan sulfate (HS) is one of the glycosaminoglycans, which has a central role in modulating skin repair. In its appearance in the skin, HS is large and highly polar and therefore unable to penetrate the skin. As a component in a topical formulation, the modified to a low molecular weight heparan sulfate analog (LMW‐HS) showed biological modulation activity. Aims This review discusses the potential role of topical formulations containing LMW‐HS in restoring aged‐skin homeostasis and skin health. Methods An expert panel of dermatologists who regularly treat clinical signs of facial photoaging explored the role of LMW‐HS containing formulations for reducing inflammation and facial‐aging signs. For this purpose, evidence from the conducted literature searches was used together with expert opinion and experience of the panel. Results Extrinsic factors contribute to skin aging through oxidative stress, stimulating inflammation involved in extracellular matrix degradation. Evidence showed that chemokines require heparan sulfate for their full range of functional activities during innate immunity. Studies showed the LMW‐HS containing topical formulation to penetrate the skin within 48 hours of once‐daily application. LMW‐HS used in the periorbital area improved discoloration and wrinkles at Week 2 with continuous improvement up to Week 12. Conclusion The LMW‐HS containing formulation showed improvements in skin condition when applied on photo‐damaged skin, indicating its therapeutic potential.

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“…Más recientemente, Sauerbronn et al 22 , en un estudio aleatorizado, doble ciego, controlado con placebo, compararon a 41 mujeres tratadas con estradiol y acetato de ciproterona frente al placebo durante seis meses, e hicieron una evaluación histológica de la piel del brazo, encontrando diferencias estadísticamente significativas entre el contenido de colágeno (aumento del 6,49 %) y elastina, la relación área de epidermis/longitud de la membrana basal, y la relación queratinocitos/longitud de la membrana basal entre los dos grupos. Entre los restantes estudios, el de Owen et al 23 es un estudio aleatorizado, doble ciego, controlado con placebo, subsidiario del estudio KEEPS (Kronos Early Estrogen Prevention Study) para la prevención de enfermedades cardiovasculares, en el que se evaluaba a mujeres con distintos tipos de tratamiento (estrógenos conjugados equinos, estradiol transdérmico) frente a mujeres sin tratamiento, no encontrándose diferencias significativas (salvo la comparación por raza). Extraer una conclusión puede resultar difícil y, antes de aconsejar el tratamiento como medida preventiva, convendría disponer de más estudios aleatorizados, doble ciegos, controlados, con un número mayor de participantes.…”

Section: Compa-artículo De Revisiónunclassified

Envejecimiento cutáneo: causas y tratamiento

González‐Guerra¹,

Alcalá²,

Guerra‐Tapia³

2017

Más Dermatol

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El envejecimiento en general, y el cutáneo en particular, es un proceso deletéreo y universal, que, sin embargo, admite diferencias individuales en función de las causas que actúan sobre el proceso. No existe una causa única, admitiéndose diferentes teorías, entre las que se encuentran las teorías no estocásticas (no azarosas), como es la genética, en la que se incluye la de la senescencia replicativa y la de los gerontogenes; y las teorías estocásticas (azarosas), que hacen referencia al daño ambiental acumulativo a través de la oxidación y la glicación producida por tabaco, sol, contaminación y otros factores entre los que se encuentra el factor hormonal.La prevención se fundamenta en una dieta sana, ejercicio físico y evitación de los factores ambientales como el tabaco y el sol mediante la fotoprotección. En el tratamiento, se consideran la terapia hormonal sustitutiva, los cosméti-cos y cosmecéuticos, las técnicas intervencionistas que se practican en la consulta (mesoterapia, implantes o rellenos, toxina botulínica, peeling químico, láser e hilos tensores) y la cirugía estética.Palabras clave: vejez, envejecimiento cutáneo, causas, teoría estocástica, teoría no estocástica, fotoprotección, hormonas, cosméticos, rejuvenecimiento, técnicas dermoestéticas. AbsTRACTAging in general, and cutaneous in particular, is a deleterious and universal process, which nevertheless admits individual differences depending on the causes that act on the process. There is no single cause, with different theories being accepted, such as non-stochastic (non-random) theories such as genetics, including replicative senescence and gerontogenes, and stochastic (random) theories that refer to cumulative environmental damage through oxidation and glycation produced by tobacco, sun, pollution and other factors including hormone factor.Prevention is based on a healthy diet, physical exercise and avoidance of environmental factors such as tobacco

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Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: four-year follow-up from the ancillary skin study of the Kronos Early Estrogen Prevention Study

Abstract: NCT00154180.

Cited by 25 publications

References 19 publications

The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature

Low molecular weight heparan sulfate containing facial skin care for reducing inflammation and restoring aged‐skin homeostasis

Envejecimiento cutáneo: causas y tratamiento

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