Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- Review

Abstract

Scan to discover onlineThe nucleolus is a subcellular membrane-less structure of eukaryotic cells. In 1965, in a world's southern summer summit in Uruguay, the role of the nucleolus as the site of ribosome synthesis, biogenesis, and processing of tRNA was conclusively established. Today, accumulating evidence confirm the multiple functions of the nucleolus, including tRNA precursor processing, cell stress sensing, as well as being influential in gene silencing, senescence, lifespan, DNA damage response (DDR), and cell cycle regulation. Therefore, nucleolopathy is observed in various human diseases. Modern advances have provided fundamental insights concerning how and why the nucleolus is targeted by different pathogenic organisms. Viruses are major organisms that disrupt the normal function of the nucleus and produce nucleoli proteins for facilitating the replication of viruses causing viral infections. In this review, we focus on the possible role of nucleoli upon coronavirus infections, particularly in coronavirus disease 2019.

Evaluación de la interacción de la proteína de matriz del virus sincitial respiratorio humano (VSRH) con la proteína nucleolar fibrilarina

“…Las cuales se encuentran relacionadas con el control del ciclo celular, replicación y reparación del ADN, regulación de la apoptosis, envejecimiento celular y detección del estrés celular. Adicionalmente, en años recientes se ha evidenciado que el nucleolo juega un papel importante en los ciclos de infección viral (Bahadori et al, 2022). A este respecto, existen diversos reportes en los cuales se ha demostrado que durante las infecciones virales ciertas proteínas de los virus tiene la capacidad de interaccionar con componentes nucleares y/o nucleolares.…”