Effects of human recombinant interleukin-1<i>β</i> on protein synthesis in rat tissues compared with a classical acute-phase reaction induced by turpentine. Rapid response of muscle to interleukin-1<i>β</i>

Ballmer, Peter E.; McNurlan, Margaret A.; Southorn, B G; Grant, I. S.; Garlick, Peter J.

doi:10.1042/bj2790683

Cited by 48 publications

(17 citation statements)

References 27 publications

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“…51 Scatter acute phase response. 57 Recently, these findings have been confirmed with protein binds to the p80 receptor. 62 In contrast, the transgenic mice either lacking a functional IL-1b or IL-1 type II receptor is a decoy receptor.…”

Section: In Vivo Studies With Cytokine Inhibitionsupporting

confidence: 68%

Proinflammatory cytokines, nutritional support, and the cachexia syndrome

Moldawer

Copeland

1997

Cancer

163

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tients with both acute and chronic inflammation secondary to either cancer, Edward M. Copeland III, M.D.chronic infectious processes, surgical injury, trauma, or burns. For the patients who cannot support themselves by enteral feeding, total parenteral nutrition remains an Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.essential tool to minimize nitrogen losses and replete the depleted patient. However, in patients with active inflammation, nitrogen retention and lean tissue accretion are often impaired during total parenteral nutrition. Production of humoral factors, including proinflammatory cytokines, regulates many of the anabolic and catabolic processes that accompany inflammation. METHODS.The investigators' experience with total parenteral nutrition and proinflammatory cytokines is reviewed. RESULTS.Cytokines such as interleukin-1, tumor necrosis factor-a, and, in particular, interleukin-6 appear to play central roles in both the loss of skeletal muscle protein and the initiation of the acute phase response to inflammation, as well as in modulating the utilization of exogenously administered nutrients. CONCLUSIONS.Although innovative second-and third-generation nutritional formulations for the acutely ill patient may represent one approach for improving the effectiveness of total parenteral nutrition, understanding the humoral response to inflammation and modifying cytokine actions pharmacologically may prove equally effective in improving the utility of exogenously administered nutrients.Future studies need to determine whether the effectiveness of exogenously administered nutrients in the patient with inflammation can be improved by efforts to modulate the proinflammatory cytokine response through cytokine inhibitors or antagonists. I nvestigation continues toward a better understanding of the relationships between proinflammatory cytokines, parenteral nutrition, and the regulation of lean tissue and body fat accretion in the hospi- ity. The contributions made by Drs. Dudrick, Rhoads, and their coinvestigators to the development of total parenteral nutrition cannot be

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Section: In Vivo Studies With Cytokine Inhibitionsupporting

confidence: 68%

Proinflammatory cytokines, nutritional support, and the cachexia syndrome

Moldawer

Copeland

1997

Cancer

163

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“…Endotoxin and sepsis elevate blood and tissue inflammatory cytokines-such as IL-1, IL-6, and TNF-␣ (10)-that regulate various aspects of muscle metabolism (3,22,36,37). However, whereas TNF-␣ has been shown to decrease IGFBP-5 secretion from C 2 myocytes (41), IL-1 and IL-6 have been reported to increase IGFBP-5 in cultured chondrocytes and osteoblasts (15,53).…”

Section: Discussionmentioning

confidence: 99%

Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism

Lang¹,

Krawiec²,

Huber³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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The purpose of the present study was to determine whether catabolic stimuli that induce muscle atrophy alter the muscle mRNA abundance of insulin-like growth factor binding protein (IGFBP)-4 and -5, and if so determine the physiological mechanism for such a change. Catabolic insults produced by endotoxin (LPS) and sepsis decreased IGFBP-5 mRNA time- and dose-dependently in gastrocnemius muscle. This reduction did not result from muscle disuse because hindlimb immobilization increased IGFBP-5. Continuous infusion of a nonlethal dose of tumor necrosis factor-α (TNF-α) decreased IGFBP-5 mRNA 70%, whereas pretreatment of septic rats with a neutralizing TNF binding protein completely prevented the reduction in muscle IGFBP-5. The addition of LPS or TNF-α to cultured C2C12 myoblasts also decreased IGFBP-5 expression. Although exogenously administered growth hormone (GH) increased IGFBP-5 mRNA 2-fold in muscle from control rats, muscle from septic animals was GH resistant and no such elevation was detected. In contrast, exogenous administration of IGF-I as part of a binary complex composed of IGF-I/IGFBP-3 produced comparable increases in IGFBP-5 mRNA in both control and septic muscle. Concomitant determinations of IGF-I mRNA content revealed a positive linear relationship between IGF-I and IGFBP-5 mRNA in the same muscle in response to LPS, sepsis, TNF-α, and GH treatment. Although dexamethasone decreased muscle IGFBP-5, pretreatment of rats with the glucocorticoid receptor antagonist RU486 did not prevent the sepsis-induced decrease in IGFBP-5 mRNA. In contrast, muscle IGFBP-4 mRNA abundance was not significantly altered by LPS, sepsis, or hindlimb immobilization. In summary, these data demonstrate that various inflammatory insults decrease muscle IGFBP-5 mRNA, without altering IGFBP-4, by a TNF-dependent glucocorticoid-independent mechanism. Finally, IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions.

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“…Changes in protein metabolism include depressing skeletal muscle protein synthesis (Jepson et al, 1986), stimulating skeletal muscle protein degradation Klasing et al, 1987), and increasing liver and heart protein synthesis (Ballmer et al, 1991). These changes in metabolism suggest altered nutritional requirements during immunologic challenge.…”

Section: Introductionmentioning

confidence: 99%