2001
DOI: 10.2460/javma.2001.218.1101
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Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs

Abstract: Hydromorphone is comparable to oxymorphone for preanesthetic sedation in dogs. Sedation is enhanced by acepromazine. Neither hydromorphone nor oxymorphone caused an increase in plasma histamine concentration.

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Cited by 85 publications
(86 citation statements)
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“…However, in dogs, the respiratory depression caused by opioids does not seem to be a concern in healthy animals unless these drugs are administered in combination with injectable or inhalational anesthetics (WAGNER, 2002). Results of the present investigation agree with previous authors who did not report the occurrence of respiratory depression, cyanosis or apnea after administration of ACP-opioid combinations (SMITH et al, 2001;MONTEIRO et al, 2008;MONTEIRO et al, 2009). …”
Section: Discussionsupporting
confidence: 93%
See 3 more Smart Citations
“…However, in dogs, the respiratory depression caused by opioids does not seem to be a concern in healthy animals unless these drugs are administered in combination with injectable or inhalational anesthetics (WAGNER, 2002). Results of the present investigation agree with previous authors who did not report the occurrence of respiratory depression, cyanosis or apnea after administration of ACP-opioid combinations (SMITH et al, 2001;MONTEIRO et al, 2008;MONTEIRO et al, 2009). …”
Section: Discussionsupporting
confidence: 93%
“…The adverse effects observed in this study were considered to be of mild to moderate intensity and are characteristic and similar to those reported in previous studies after administration of ACP-opioid combinations (SMITH et al, 2001;MONTEIRO et al, 2008;MONTEIRO et al, 2009). The duration, but not the severity of adverse effects, appeared to be greater in dogs given morphine than in other treatments.…”
Section: Discussionsupporting
confidence: 89%
See 2 more Smart Citations
“…Overall, the degree of hypercapnia and hypoxemia observed in dogs that received LEH was comparable to that observed with hydromorphone HCl, a drug that has already been deemed safe and is very popular in veterinary medicine for pain management and preanesthetic sedation in dogs (Pettifer and Dyson, 2000; Smith et al, 2001). While there were some statistically significant differences at some time points between placebo-treated dogs and the 2 groups that received either hydromorphone HCl or LEH, values for P a CO 2 , P a O 2 , and pH remained within normal limits (Table 1).…”
Section: Discussionmentioning
confidence: 53%