Effects of hydroxyapatite tricalcium phosphate coating and intracancellous placement on bone ingrowth in titanium fibermetal implants

Dean, John C.; Tisdel, C L; Goldberg, Victor M.; Parr, J. Andrew; Davy, Dwight T.; Stevenson, Sharon

doi:10.1016/s0883-5403(05)80083-x

Cited by 46 publications

(38 citation statements)

References 26 publications

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“…This might be explained by the use of different experimental models and coating vendors, resulting in ceramic coatings of different qualities. 46,53 Moreover, different evaluation methods were applied. Conventional histomorphometric evaluation of bone implants by tradition has been of transverse sections without considering the orientation of the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

Resorption of hydroxyapatite and fluorapatite ceramic coatings on weight-bearing implants: A quantitative and morphological study in dogs

Overgaard

Lind

Josephsen

et al. 1998

J. Biomed. Mater. Res.

106

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Resorption (defined as loss of ceramic coating because of cellular activity or dissolution) of ceramic coatings is a matter of concern for the long-term performance of ceramic-coated implants. A new fluorine-containing coating, fluorapatite (FA), has been shown to be more stable than hydroxyapatite (HA) in unloaded models. In a weight-bearing model in trabecular bone, we evaluated loss (defined as reduction of coating irrespective of type of mechanism) of HA and FA coatings during 25 weeks of implantation. Eight mature dogs had HA- or FA-coated implants inserted bilaterally into the weight-bearing region of the medial femoral condyle. Quantified loss of ceramic coating was estimated at the light microscopic level using stereological methods. The experiment showed significant loss of both types of coatings. However, no statistical difference in loss of ceramic coating was found regarding surface area implant coverage, volume, and thickness (p = 0.77, p = 0.13, p = 0.56, p = 0.23, respectively). Completely resorbed HA coating was replaced by 36 +/- 6.0% (range: 26-42) bone in direct contact with the implant surface compared with 29 +/- 16.0% (range: 12-59) for FA (p = 0.40), suggesting that the implant was firmly fixed despite loss of the ceramic coating. Transmission electron microscopy in combination with electron energy spectroscopy and electron spectroscopic imaging showed that osteclast-like cells, osteocytes, macrophage-like cells, and fibroblasts had phagocytosed calcium-containing fragments, indicating cell-mediated resorption of the ceramic coating.

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Section: Discussionmentioning

confidence: 99%

Resorption of hydroxyapatite and fluorapatite ceramic coatings on weight-bearing implants: A quantitative and morphological study in dogs

Overgaard

Lind

Josephsen

et al. 1998

J. Biomed. Mater. Res.

106

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show abstract

“…A high frequency study using the Olympus UH3 SAM (Olympus Co., Tokyo, Japan) at Case Western Reserve University (CWRU) was performed using a 400 MHz burst-mode lens on histologically prepared samples of porous Ti plugs with and without hydroxyapatite coatings that had been inserted in rabbits at CWRU [146][147][148]. The SAM study showed that there were significant differences in formation and remodeling from woven to haversian bone as a function of both time of implantation and the presence or absence of hydroxyapatite coating in the pores [149].…”

Section: Properties Of the Bone/implant Interfacementioning

confidence: 99%

Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces

Katz

Misra

Spencer

et al. 2007

Materials Science and Engineering: C

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This paper presents a review plus new data that describes the role hierarchical nanostructural properties play in developing an understanding of the effect of scale on the material properties (chemical, elastic and electrical) of calcified tissues as well as the interfaces that form between such tissues and biomaterials. Both nanostructural and microstructural properties will be considered starting with the size and shape of the apatitic mineralites in both young and mature bovine bone. Microstructural properties for human dentin and cortical and trabecular bone will be considered. These separate sets of data will be combined mathematically to advance the effects of scale on the modeling of these tissues and the tissue/biomaterial interfaces as hierarchical material/structural composites. Interfacial structure and properties to be considered in greatest detail will be that of the dentin/adhesive (d/a) interface, which presents a clear example of examining all three material properties, (chemical, elastic and electrical). In this case, finite element modeling (FEA) was based on the actual measured values of the structure and elastic properties of the materials comprising the d/a interface; this combination provides insight into factors and mechanisms that contribute to premature failure of dental composite fillings. At present, there are more elastic property data obtained by microstructural measurements, especially high frequency ultrasonic wave propagation (UWP) and scanning acoustic microscopy (SAM) techniques. However, atomic force microscopy (AFM) and nanoindentation (NI) of cortical and trabecular bone and the dentin-enamel junction (DEJ) among others have become available allowing correlation of the nanostructural level measurements with those made on the microstructural level.

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“…Comparable survival rates have been reported using cementless techniques for the femoral component (10 -14). In the acetabular component, 10-year survival rates are similar for cemented (95%) and cementless (95-100%) techniques; however, at 15 years, cementless technology supercedes cemented techniques (70 -95% cemented versus 85-94% cementless) (6,7,10,11,(15)(16)(17). Consequently, either cemented or cementless femoral stems could be considered the gold standard for long-term success; however, cementless techniques are now the preferred method for the vast majority of acetabular reconstructions.…”

Section: Surgical Advances In Hip and Knee Arthroplastymentioning

confidence: 99%

“…These implants demonstrate tremendous bone and soft tissue ingrowth and are now being used in an expanding number of clinical indications for both primary and revisional hip surgery (18,19). There has also been experimentation with bioactive ceramic coatings such as hydroxyapatite or tricalcium phosphate that are amenable to bone healing (15,20,21). Radiographs have shown improvements in bone ingrowth with the bioactive coatings; however, there have been no demonstrated effects on survivorship of the implants.…”

Section: Surgical Advances In Hip and Knee Arthroplastymentioning

confidence: 99%

Update on hip and knee arthroplasty: Current state of evidence

Jones¹,

Westby²,

Greidanus³

et al. 2005

Arthritis & Rheumatism

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Effects of hydroxyapatite tricalcium phosphate coating and intracancellous placement on bone ingrowth in titanium fibermetal implants

Cited by 46 publications

References 26 publications

Resorption of hydroxyapatite and fluorapatite ceramic coatings on weight-bearing implants: A quantitative and morphological study in dogs

Resorption of hydroxyapatite and fluorapatite ceramic coatings on weight-bearing implants: A quantitative and morphological study in dogs

Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces

Update on hip and knee arthroplasty: Current state of evidence

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