Effects of hyperbaric oxygen treatment on implant osseointegration in experimental diabetes mellitus

Abstract

Objective To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointegration in diabetic rabbits.Material and Methods An experimental diabetes model was induced in 32 New Zealand rabbits through IV injection of alloxan. After the state of diabetes had been confirmed, one dental implant was placed in the metaphysical region of each animal’s tibia. After the implants’ placements, the animals were divided into two groups. Half of the animals underwent HBO treatment, while the other group did not receive HBO treatment and served as the control group. The animals were euthanized at the 4th and 8th weeks. The osseointegration of the implants were compared by histomorphometry and resonance frequency analysis (RFA).Results The Bone Implant Contact (BIC) values were significantly higher in the HBO group than in the control group at the 4th week. There was no difference in the BIC values between the groups at the 8th week. There was no significant difference in the RFA scores between the groups both at the 4th and 8th weeks after the operation.Conclusion Histomorphometry findings suggest that HBO has positive effect on implant osseointegration in the early healing period in diabetic rabbits. However, implant stability is not affected by HBO treatment.

Bone Marrow Mesenchymal Stromal Cells (BMMSCs) Augment Osteointegration of Dental Implants in Type 1 Diabetic Rabbits: An X-Ray Micro-Computed Tomographic Evaluation

“…Implants in diabetic patients are susceptible to diminished osseointegration and early implant failures [2]. Though reports suggest methods to enhance osseointegration in diabetic conditions [22][23][24], there were limited studies on the use of stem and progenitors from various anatomical niches for effective osseointegration. In the present study, we found that there was a significant increase in the bone quality around the implants under the influence or adjunct effect of osseo-inductive BMMSCs + PRP in both uncontrolled diabetic and normal rabbits.…”

“…The intimate contact of the bone to the foreign material is conventionally analyzed by histomorphometry; however, studies suggest µCT analysis produces comparable results [21]. There are studies in the literature on the enhancement of bone to implant osseointegration in diabetes mellitus [22][23][24], but little about tissue regeneration by stem cells. We performed the study, aiming to evaluate the effect of stem cell therapy on the implant osseointegration in uncontrolled type I diabetic New Zealand rabbits using µCT analysis.…”

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

“…Of the various breeds, the New Zealand White rabbit (5 to 6 Kg) is the most commonly chosen for implantology research ( Table A1 ). This species is of particular interest with the advent of transgenic rabbits (for hormone regulation [ 65 ], diabetes [ 66 ], and osteoporosis [ 67 ]). Thanks to its accelerated skeletal maturity (at around 6 months of age) and rapid bone turnover (faster than that in primates), the rabbit is a convenient model for laboratory research [ 68 ].…”

Clinical Assessment of the Hyperbaric Oxygen Therapy Efficacy in Mild to Moderate Periodontal Affections: A Simple Randomised Trial

“…Altug et al [23], studied the consequences of HBO therapy on implant osseointegration in experimental diabetes rabbits. The authors concluded that the disclosures in histomorphometry hint that HBO therapy has a certain impact on the osseointegration of dental implants, in the early healing time in diabetic rabbits.…”