Effects of Hypercalcemia, Hypercalcemia and Calcitonin on Glucose Stimulated Insulin Secretion in Man

Ziegler, Reinhard; Bellwinkel, S.; Schmidtchen, D.; Minne, H. W.

doi:10.1055/s-0028-1097084

Cited by 32 publications

(10 citation statements)

References 1 publication

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“…Numerous factors may contribute to this alteration and the mechanism remains speculative. The increased CT level might represent a secondary response to insulin hypersecretion and to the increase in intracellular Ca concentration: C T is known to inhibit glucose-stimulated insulin secretion (24) and to stimulate Ca efflux from the cells of various tissues (25). The increase in C T levels might also be secondary to the delayed rise in the glucagon levels which occurs after glucose and insulin increase: in fact glucagon is known to release CT (26).…”

Section: Discussionmentioning

confidence: 99%

Mineral Metabolism in Obese Children

et al. 1988

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Blood levels of glucose, insulin (IRI), Calcium (Ca), phosphorus (P), alkaline phosphatase (AP), osteocalcin (OC), parathyroid hormone (PTH), calcitonin (CT), 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and urinary excretion of Ca (Ca/Cr), P (TmP/GFR), hydroxyproline (OH-P/Cr) and cyclic AMP (cAMP/GFR) were determined in 16 obese children, aged 8 to 11 years, on a diet rich in calories and carbohydrates and in 15 controls of the same age. Blood glucose, IRI, Ca, P, PTH and CT were also determined in both groups of subjects, during an oral glucose tolerance test (OGTT). In basal conditions glucose, IRI, AP, OC, PTH, CT and 1,25(OH)2D3 levels were significantly higher, and 25OHD3 levels lower, in obese children than in controls. Urinary Ca/Cr, TmP/GFR were lower in obese than in non obese children, while OH-P/Cr and cAMP/GFR were higher. Bone mineral content (BMC), measured by photon absorptiometry, and BMC/bone width ratio were lower in obese than in non obese children. During OGTT serum Ca and P decreased and serum PTH and CT increased less in obese than in non obese children. In obese children receiving a diet with high carbohydrate content, an alteration of mineral metabolism occurred, characterized by secondary increase of PTH and 1,25(OH)2D3. Ca decreased and PTH and CT increased less markedly during OGTT.

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Section: Discussionmentioning

confidence: 99%

Mineral Metabolism in Obese Children

et al. 1988

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“…Intravenous glucose tolerance was assessed in twelve patients by giving glucose 0.33 gikg body weight i.v. (Ziegler et al, 1972). Plasma for insulin assay was separated by centrifugation and stored at -20°C.…”

Section: Methodsmentioning

confidence: 99%

“…High or low calcium levels were found to enhance, or suppress, glucose-induced insulin secretion respectively. Acute experiments in man, in w h c h hypercalcaemia was induced by calcium infusion, also revealed increased glucoseinduced insulin output (Ziegler et al, 1972). Few studies in man, however, have focused attention on the effects on insulin secretion of sustained variations in plasma calcium concentration within a pathophysiological range (Kim et al, 1971 ;Yasuda et al, 1975) and this was, therefore, the purpose of this study.…”

mentioning

confidence: 95%

Glucose‐induced Insulin Secretion in Patients With Parathyroid Disorders

Hague

Cullen

Martin

1978

Clinical Endocrinology

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Glucose-induced insulin secretion was studied in ten patients with primary hyperparathyroidism and two with idiopathic hypoparathyroidism both before and after treatment. In each individual, insulin secretion during an intravenous glucose tolerance test was greater when the plasma calcium was higher. No consistent change in insulin secretion with plasma calcium concentration was observed during an oral glucose tolerance test. These findings could be explained by the suggestion that insulin secretion provoked by orally administered glucose is enhanced by gut hormones which may stimulate insulin secretion by a mechanism independent of extracellular calcium.

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“…Contrary to Gig, reports on the effect of Ct on glucose metabolism in man are scarce. In man, Ziegler et al (1972) described a decline of IRI and a decrease of rate of glucose assimilation, Blahos, Svoboda and Hoschl (1976) observed a rise of BS without any changes of IRI after administration, and more recently, Cantalamessa et al (1978) have found a decrease of IRI (both native and stimulated) and a blunted response of GH to arginine stimulation.…”

Section: Discussionmentioning

confidence: 96%

Comparison of Metabolic Effects of Glucagon and Calcitonin and Assessment of Direct Effect of Glucagon on Calcitonin Level in Athyroid Man

Zamrazil¹,

Nĕmec²,

Neradilová³

et al. 1981

Horm Metab Res

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The effect of intramuscular administration of glucagon (Glg) and calcitonin (Ct) on the pattern of serum calcium (Ca), in organic phosphorus (P), blood glucose (BS), immunoreactive insulin (IRI) and growth hormone (GH) was investigate in 14 patients after total thyroid ablation during replacement therapy. In seven patients the pattern of Ct after Glg administration was assessed in the same conditions. Both hormones induced a prompt and marked decrease of Ca with out any differences between effect of Glg and Ct. The decline of P due to Glg is more rapid and marked than the due to Ct, the difference being significant from 60 to 120 min. Glg caused a rapid and marked rise of BS and IRI with a tendency toward normalization up to 180 min, GH rose significantly from 120 to 180 min. The changes of BS and IRI due to Ct were slow and less marked, but prolonged: level of BS increased and that of IRI decreased. No effect of Ct administration on GH was recorded. In general, neither the effects of Glg nor those of Ct were influenced by hypothyroidism. This fact may be of importance for use of Glg in testing GH reserve in hypothyroidism. Ct after Glg administration in athyroid patients failed to exhibit any significant changes. Thus our results support the assumption about similar and independent action of Glg and Ct on calcium and phosphate homeostasis and different effects of both hormones on glucose metabolism.

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Effects of Hypercalcemia, Hypercalcemia and Calcitonin on Glucose Stimulated Insulin Secretion in Man

Cited by 32 publications

References 1 publication

Mineral Metabolism in Obese Children

Mineral Metabolism in Obese Children

Glucose‐induced Insulin Secretion in Patients With Parathyroid Disorders

Comparison of Metabolic Effects of Glucagon and Calcitonin and Assessment of Direct Effect of Glucagon on Calcitonin Level in Athyroid Man

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