The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium.These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.

Rats were treated with lithium chloride over 6 weeks. During the experiment, determinations of serum calcium, magnesium and phosphorus revealed no changes due to the therapy. Postmortem examinations of liver, skeletal muscle, and femur minerals as well as bone histology showed these organs to be unaffected by lithium application. Only body weight gain was in part increased by lithium.

No abstract

In an additional experiment PTH and DBcAMP effects on serum 47 Ca activity were measured in PTX rats with prelabelled bone: DBcAMP did not cause a significant rise in serum 47 Ca as did PTH. ConcIusionsDBcAMP elevates serum Ca by increased intestinal Ca absorption. The amount of Ca being additionally absorbed after DBcAMP treatment was not utilized by deposition in bone, but excreted in the urine. DBcAMP did not alter serum Ca in starving rats. This and the absence of increased 47Ca remobilization from prelabelled bone by DBcAMP indicates that DBcAMP does not increase serum Ca by stimulating bone resorption. PTH increases bone resorption in PTX rats and intestinal Ca absorption in intact rats. The reduction of Ca Absorption by PTH in PTX rats remains unexplained and needs further investigation.

Das verhältnismäßig seltene Vorkommen der hypercalciämischen Krise bringt es mit sich, daß bis zu ihrer Erkennung und der Wahl der optimalen Behandlung Zeit verlorengeht, die für den Patienten eine zusätzliche Gefährdung bedeutet. In kürzeren Mitteilungen hatten wir bereits auf dieses Krankheitsbild hingewiesen (18, 61, 62). SymptomatikSobald der Calciumspiegel im Blute über seine obere Normgrenze ansteigt, die bei 5,5 mval/l (11 mg/lOO ml)