Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence

Coppenolle, Fabien Van; Slomianny, Christian; Carpentier, F.; Bourhis, Xuefen Le; Ahidouch, Ahmed; Croix, Dominique; Legrand, Guillaume; Dewailly, Etienne; Fournier, Sarah; Cousse, Henri; Authie, D.; Raynaud, Jean‐Pierre; Beauvillain, Jean-Claudé; Dupouy, Jean‐Paul; Prevarskaya, Natalia

doi:10.1152/ajpendo.2001.280.1.e120

Cited by 80 publications

(98 citation statements)

References 66 publications

(88 reference statements)

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“…The demonstration by Van Coppenolle et al (30) that hyperprolactinemia is effective to induce prostate enlargement in castrated DHT-implanted animals is not contradicted by the present findings. Besides, augmenting the amount of prostatic DHT by increasing both 5a-R isozymes, PRL probably enhances the effects of DHT in this gland.…”

Section: Discussionsupporting

confidence: 60%

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Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats

et al. 2007

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SummaryProlactin (PRL) is implicated in prostate growth and in the development and regulation of benign prostatic hypertrophy (BPH) and prostate cancer (PCa). PRL may exert its effects on prostate in synergism with androgens. The most active androgen in the prostate is the 5a-dihydrotestosterone (DHT) obtained from testosterone by the 5a-reductase (5a-R) enzyme, which is expressed in the prostate as two isozymes, 5a-R1 and 5a-R2. In this study, sulpiride, a prolactin-secretion inductor, was administered to male rats. mRNA levels of 5a-R1 and 5a-R2 were measured in prostate of controls and sulpiride-treated rats, using one-step quantitative RT-PCR coupled with laserinduced fluorescence capillary electrophoresis (LIF-CE). Results demonstrated that sulpiride-induced hyperprolactinemia is associated with an increase in mRNA levels of both 5a-R1 and 5a-R2 in prostate of adult rats. Although a direct effect of sulpiride on prostate gland cannot be ruled out, hyperprolactinemia may be a factor to be considered in aging males, in whom prostatic diseases such as BPH and PCa are more frequent. IUBMBIUBMB Life, 60(1): [68][69][70][71][72] 2008

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Section: Discussionsupporting

confidence: 60%

“…Chronic hyperprolactinemia was induced by daily intraperitoneal (i.p.) injections of 40 mg/kg aqueous sulpiride solution (Sigma) according to Van Coppenolle et al (30). The rats were always injected at 9:00 a.m. At 30 min, after the final injection, the rats were euthanized by decapitation to avoid possible adverse effects of anesthesia.…”

Section: Animalsmentioning

confidence: 99%

Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats

et al. 2007

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“…Similarly, dilation of the bulbourethral glandular acini or ducts, progressing to cystic atrophy may be observed in aging rats and mice where enlarged bulbourethral glands are often sampled as gross abnormalities (Kiupel, Brown, and Sundberg 2000;Wardrip et al 1998). Diffuse acinar or vesicle dilation due to increased secretory product and accompanied by organ weight increase has been reported as a druginduced finding, and has also been described with hyperprolactinemia and hyperandrogenism (Coert et al 1985;Van Coppenolle et al 2001). (Gordon, Majka, and Boorman 1996;Liu and Hurtt 1996;Stolte 1993;Sugimura, Cunha, and Donjacour 1986;Suwa et al 2002).…”

Section: Bulbourethral Glandmentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

207

198

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…The released estrogens cause increased stimulation of the prostatic stroma, resulting in excessive proliferation of the prostate and occurrence of BPH (Krieg et al, 1995;Shibata et al, 2000). Indeed, it has been suggested that estrogen is a major risk factor of BPH (Seppelt, 1978;Van Coppenolle et al, 2001). Although the mechanism by which estrogen leads to the development of BPH has not been fully understood, available studies have shown that estrogen has direct and indirect effects at the cellular level on the prostate.…”

Section: Discussionmentioning

confidence: 99%

Qianliening capsule treats benign prostatic hyperplasia through regulating the expression of sex hormones, estrogen receptor and androgen receptor

Zhou¹,

Lin²,

Xu³

et al. 2012

Afr. J. Pharm. Pharmacol.

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The objective of the study is to evaluate the effect of Qianliening capsule (QLNC) on the expression levels of serum hormones, prostatic estrogen receptor and androgen receptor in benign prostatic hyperplasia (BPH) rats, and investigate the possible molecular mechanisms mediating its anti-BPH activity. Male Sprage-Dawley (SD) rat BPH model was generated. BPH rats were orally treated with different concentrations of QLNC. Blood and the prostatic tissues of animals were obtained. The prostatic weight (PW) and prostatic index (PI) were evaluated; the histopathological changes of prostatic tissue, the levels of serum testosterone and estradiol, the mRNA and protein expression of ER and AR in prostatic tissue were examined by microscopy with hematoxylin and eosin staining HE staining, ELISA, RT-PCR, immunohistochemistry, respectively. Compared to the model group, the PW and PI in all QLNC-treated groups have significantly lower (p<0.05) serum than T/E 2 in QLNC-treated groups which was elevated significantly (p<0.05 or p< 0.01). Pathomorphism of prostatic tissue in QLNC-treated groups improved. The mRNA and protein expression of ER and AR in QLNC-treated groups decreased significantly. QLNC has significant therapeutic effect on BPH rats. Improvement of sex hormones disorder and regulation of ER and AR are one of the mechanisms by which QLNC treats BPH.

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Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence

Cited by 80 publications

References 66 publications

Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats

Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Qianliening capsule treats benign prostatic hyperplasia through regulating the expression of sex hormones, estrogen receptor and androgen receptor

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