Effects of Hypophysectomy, Castration, and Testosterone Propionate on Hemopoiesis in the Adult Male Rat1

Crafts, Roger C.

doi:10.1210/endo-39-6-401

Cited by 44 publications

(8 citation statements)

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“…These authors have stated that the increase in haematocrit and haemoglobin values observed in man during treatment with androgenic hormones may be due to plasma volume contraction rather than to total red-cell volume expansion. Since these findings differ from those observed in our laboratory (Gardner and Pringle, 1961) and in others (Kennedy and Gilbertsen, 1957;Booj and Kuypers, 1962;Crafts, 1946; Meduri and Petronio, 1957;Van Dyke, Contopoulos, Williams, Simpson, Lawrence and Evans, 1954;Fried, DeGowin, Forde and Gurney, 1964), we present in this communication extension of data previously noted (Gardner, 1962) regarding the effects of treatment of elderly men with a potent androgen. In our opinion the results of these studies provide strong evidence that the blood volume response to androgen in man is usually characterized by an increase in total red-cell volume and in plasma volume.…”

contrasting

confidence: 51%

The Erythrocythaemic Effects of Androgen

et al. 1968

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contrasting

confidence: 51%

The Erythrocythaemic Effects of Androgen

et al. 1968

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“…In fact, except for normocytic anemia, the complete blood cell count was normal in all the patients. Clinical and experimental data in humans and other animals have documented a similar phenomenon [7][8][9][10][11][12][13][14]. The anemia in these animals resolved with the exogenous administration of androgens.…”

Section: Discussionmentioning

confidence: 95%

Anemia After Orchiectomy

et al. 1998

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The decrease in testosterone production associated with bilateral orchiectomy may result in normocytic anemia in men. We sought to determine the effect of orchiectomy on hemoglobin concentration. Patients were evaluated at the Mayo Clinic in 1993 and 1994 and underwent bilateral orchiectomy for prostate carcinoma. All patients were seen by one of the staff urologists. Patients were included if they had a normal preoperative complete blood cell count and serum levels of creatinine, if they remained without disease progression (suppressed prostate-specific antigen level and no evidence of clinical progression on review), and if they had normal serum levels of creatinine and mean corpuscular volume during the follow-up period. The patients could have no other cause of anemia. The complete blood cell count, prostate-specific antigen level, and serum level of creatinine were determined preoperatively and at least once (>90 days) after orchiectomy. Sixty-four patients were included in the analysis (median age, 68 years). The median decrease in hemoglobin concentration was 1.2 g/dL after orchiectomy. There was a statistically significant difference in the hemoglobin concentration before orchiectomy compared with postoperative values at all the intervals studied, both by the paired group t-test and the Kruskal-Wallis test. There is a clinically and statistically significant decrease in hemoglobin concentration after orchiectomy. Knowledge of this phenomenon may prevent unnecessary diagnostic work-up in men with normocytic anemia after bilateral orchiectomy.

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“…9 The interested reader is referred to an excellent review 10 on this topic by the group of Dr Basaria, guest editor of this special section of the Asian Journal of Andrology. Such early animal experiments provided an explanation for the observation that adult men have higher red blood counts and hemoglobin levels (about 1-2 g dl 21 ) than adult women.…”

Section: Androgens and Erythropoiesis: Clinical Studiesmentioning

confidence: 99%

Hematological changes during androgen deprivation therapy

Grossmann¹,

Zajac²

2012

Asian J Androl

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Androgen deprivation therapy (ADT) has been associated with a plethora of adverse effects, consistent with the androgen dependency of multiple reproductive and somatic tissues. One such tissue is the hemopoietic system, and one of the most predictable consequences of ADT is the development of anemia. Although anemia caused by ADT is rarely severe, ADT is often given to frail, elderly men with increased susceptibility to anemia due to multiple other causes. ADT-associated anemia may contribute to fatigue and reduced quality of life (QoL) in such men, although this requires further study. While anemia is an independent risk factor of mortality in men with prostate cancer, it is not known whether treatment of ADT-associated anemia alters clinically important outcomes, or whether treatment affects mortality. Awareness of the phenomenon of ADT-induced anemia should avoid unnecessary work-up in mild cases of normocytic normochromic anemia. However, assessment and treatment of more severe anemia may be required. This should be determined on an individual basis. In contrast to the well-described actions of ADT on erythropoiesis, its effect on other hemopoietic lineages has been less well elucidated. While preclinical studies have found roles for androgens in maturation and differentiated function of neutrophils, lymphocytes and platelets, the implications of these findings for men with prostate cancer receiving ADT require further studies.

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Effects of Hypophysectomy, Castration, and Testosterone Propionate on Hemopoiesis in the Adult Male Rat1

Cited by 44 publications

References 0 publications

The Erythrocythaemic Effects of Androgen

The Erythrocythaemic Effects of Androgen

Anemia After Orchiectomy

Hematological changes during androgen deprivation therapy

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