The Erythrocythaemic Effects of Androgen

Gardner, Frank H.; Nathan, David G.; Piomelli, Sergio; Cummins, James F.

doi:10.1111/j.1365-2141.1968.tb00367.x

Cited by 38 publications

(13 citation statements)

References 9 publications

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“…These gender differences in RBC parameters as illustrated in our findings (Table 2), are consistent with previously established evidence that males have higher values than females for these parameters and is partly attributed to the influence of the androgen hormone on erythropoiesis [43,44] and to menstrual blood loss in women [16,25,39,42,45]. It has been reported that estrogens lower the Hb through hemodilution while testosterone increases the plasma volume but increases circulating RBC to an even greater extent [46]. Age-related differences in the RBC component have also been observed among male participants, with adults (≥18 years) having higher levels of Hb, Hct and RBC compared to male adolescents (13-17 years) as shown here (Table 2) [9].…”

Section: Laboratory Reference Intervals In Africa 309supporting

confidence: 81%

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Laboratory Reference Intervals in Africa

Zeh¹,

Odhiambo²,

Mills³

2012

Blood Cell - An Overview of Studies in Hematology

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Section: Laboratory Reference Intervals In Africa 309supporting

confidence: 81%

“…Generally, no ethnic or age differences are observed between Caucasian and African populations [46]. Monocyte counts in Eastern and Southern Africa are comparable to the US derived valuesand thus there is no need for separate reference intervals [9,20].…”

Section: Monocytesmentioning

confidence: 70%

Laboratory Reference Intervals in Africa

Zeh¹,

Odhiambo²,

Mills³

2012

Blood Cell - An Overview of Studies in Hematology

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“…The usual explanation, of the effect of androgens on erythropoiesis, does not explain the difference between species 2. The explanation of Rushton et al of iron deficiency among females, does not withstand scrutiny 1…”

mentioning

confidence: 99%

Haemoglobin and ferritin concentrations in men and women: cross sectional study

Waalen

2002

BMJ

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Rushton et al found that of all the primates, only in humans do females have lower blood haemoglobin concentrations than males. 1 The usual explanation, of the effect of androgens on erythropoiesis, does not explain the difference between species.2 The explanation of Rushton et al of iron deficiency among females, does not withstand scrutiny. Participants, methods, and resultsWe are engaged in a large scale study of iron storage disease in patients attending a health appraisal centre at Kaiser Permanente, San Diego. Approximately 500 000 people, a third of the population of San Diego's metropolitan area, are members of this medical care programme. Patients with Medicare or in an employee group can join. In any four year period, 81% of members over the age of 26 attend the centre. Most members are in good health.3 These patients are an ideal group on which to test the proposal that the difference in haemoglobin values of men and women is largely due to iron deficiency, because we have obtained transferrin saturation and serum ferritin concentrations from all of the patients. So far 26 614 white participants aged 26 to 99 years have been screened.We used a comprehensive questionnaire and medical records to exclude patients who have diseases that might influence the haemoglobin concentration in the blood. Rheumatoid arthritis (1048 patients) and chronic renal failure (seven patients) were considered to have the greatest chronic effect on the normal ironhaemoglobin relationship. No other exclusions were made.Of the remaining 25 559 participants, 12 731 were men and 12 828 were women. Part a of the figure shows that mean haemoglobin concentrations are greater in men than in women at any given age. Parts b and c of the figure show an approximate 10 g/l difference in mean haemoglobin concentrations between men and women aged 26 to 55 years at any given transferrin saturation or serum ferritin concentration. This apparent difference in haemoglobin concentration between the sexes, therefore, is not because of iron deficiency. Neither do our data support the suggestion that this sex difference vanishes with age: part d of the figure shows a difference of about 10 g/l exists at each transferrin saturation concentration between men and postmenopausal women older than 55 years. CommentThe evidence does not support the idea that the lower haemoglobin concentrations in women are due to iron deficiency. We agree that iron deficiency is an important health problem, and we have repeatedly made this point over more than 40 years. 4 In claiming that humans are the only menstruating primates to have sex differences in haemoglobin values, Rushton et al overlooked a study establishing reference ranges for haemoglobin in cynomolgus macaques. 5 In that study, a statistically significant difference of approximately 10 g/l in mean haemoglobin concentrations was found between male macaques (120 g/l) and female macaques (110 g/l) despite similar mean ferritin values between the sexes. 5 This is manuscript number 14266-MEM from The Scr...

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“…1 Les hommes ont un hEmatocrite et un taux d'hEmoglobine supErieurs ~ ceux des femmes [36]. Le r61e des androg~nes dans ce dimorphisme sexuel est 6tabli par de multiples observations [20], mEme si le mEcanisme en reste discut6 [2,14,35,41]. I1 est 6galement connu depuis longtemps que l'hEmatocrite et le taux d'hEmoglobine diminuent avec l'~ge [15,41].…”

Section: Recommandation 13 [32]unclassified

Diagnostic, traitement et surveillance de l’hypogonadisme de survenue tardive chez l’homme: Recommandations officielles de l’International Society for the Study of the Aging Male (ISSAM) et commentaires

Cuzin

Jamin

et al. 2003

Androl.

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The Erythrocythaemic Effects of Androgen

Cited by 38 publications

References 9 publications

Laboratory Reference Intervals in Africa

Laboratory Reference Intervals in Africa

Haemoglobin and ferritin concentrations in men and women: cross sectional study

Diagnostic, traitement et surveillance de l’hypogonadisme de survenue tardive chez l’homme: Recommandations officielles de l’International Society for the Study of the Aging Male (ISSAM) et commentaires

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