Effects of hypotension on hepatic circulation and function: comparison of brain death and exsanguination models

Ischemic preconditioning of the liver: A few perspectives from the bench to bedside translation

“…62,63 In such a scenario the effects of hepatic warm ischemia during IPC could be different from those in normotensive patients undergoing LR. Furthermore, brain death induces a multifaceted, intense systemic inflammatory response, which manifests in many organs, including the liver.…”

Effects of cortisol administration on hepatic circulation during brain death in rabbits

“…13 Supplementation of cortisol recovered PVF and HTF to pre-brain death levels despite sustained hypotension elicited by brain death. On the other hand, the adrenalectomized non-brain-dead rabbits exhibited a significant decrease in PVF and HTF, with the systemic blood pressure being maintained.…”

“…Recently, we have shown that reduced hepatic circulation in hypotensive brain-dead rabbits was associated with a rapid decrease in cortisol levels from the circulation. 13 Furthermore, we have demonstrated that, in a controlled hypotension Effects of cortisol administration on hepatic circulation during brain death in rabbits Surgery Ogawa et al 451 Volume 131, Number 4 rabbit model, the hepatic circulation is restored associated with increased cortisol levels in the circulation. 13 These findings suggest that cortisol contributes greatly to maintaining the hepatic circulation during brain death.…”

“…Recently, we have shown that reduced hepatic circulation in hypotensive brain-dead rabbits was associated with a rapid decrease in cortisol levels from the circulation. 13 Furthermore, we have demonstrated that, in a controlled hypotension Background. Hemodynamic instability and endocrinologic alterations during brain death contribute to dysfunction of donor organs.…”

Short-Term Effects of Hydroxyethylstarch Resuscitation on Systemic and Regional Hemodynamics and Metabolism in a Brain-Dead Canine Model

“…Different experimental models have been used to address the impact of brain death in the hepatosplanchnic perfusion and graft function [19][20][21]. The systemic hemodynamic changes observed in brain-dead donors, as well as the extent of catecholamine release, depend on the rate of rise of intracranial pressure [20,[22][23][24].…”