Effects ofAngelica gigasNakai on the production of decursin‐ and decursinol angelate‐enriched eggs

Abstract

BACKGROUND The livestock industry requires high‐quality products, as well as improved productivity. There have been many studies regarding the utilization of feed additives aiming to increase productivity, enhance immune functions and prevent infectious diseases in livestock. Biofunctional feed additives would be beneficial not only for animal health, but also for consumers. In the present study, we utilized root and byproduct (stem and leaf) powders of Angelica gigas Nakai (AGN, Korean Danggui) as feed additives and examined the deposition of biofunctional compounds, such as decursin and decursinol angelate, into egg white and yolk. RESULTS We optimized the detection system for decursin and decursinol angelate, and determined the amounts of decursin and decursinol angelate derived from AGN byproducts (stem and leaf) as well as root. In Experiment 1, laying hens were fed with the dried AGN root powder and the effective compounds were detected in egg white and yolk. Subsequently, in Experiment 2, we examined AGN byproducts as an alternative feeding supplement. Additionally, biochemical parameters were analyzed to evaluate changes in the health of the hens by feeding AGN root powder. The results obtained indicated that decursin and decursinol angelate were stably transferred into egg white and yolk by feeding AGN byproducts as well as root. Intriguingly, plasma cholesterol levels were significantly decreased in a dose‐dependent manner, and those of interleukin‐1β, as an immune‐related biomarker, were considerably increased in the treated hens. CONCLUSION These results indicated that AGN root and byproducts (stem and leaf) could be utilized for the production of value‐added eggs and improving the health of hens in the poultry industry. © 2018 Society of Chemical Industry

Functional efficacy analysis ofAngelica gigasNakai on chicken myoblast cells through cell‐based in vitro assay

“…Generally, coumarin derivatives, such as decursin and its isomer, decursinol angelate, are the primary effective compounds isolated from the AGN plant and have attracted attention because of their numerous pharmacological effects (Cho et al, ; Hwang et al, ; Mahat et al, ). In the previous report, we found that the amounts of decursin and decursinol angelate in the stem and leaf of AGN were approximately one‐third of those in the root, indicating that, as byproducts, the stem and leaf could be utilized to provide supplementary bioactive material (Fontamillas et al, ).…”

“…In the previous report, we found that the amounts of decursin and decursinol angelate in the stem and leaf of AGN were approximately one-third of those in the root, indicating that, as byproducts, the stem and leaf could be utilized to provide supplementary bioactive material (Fontamillas et al, 2019).…”

“…AGN could be a promising herbal plant to improve animal health, performance, and a potential alternative for replacing antibiotics in the livestock industry. Moreover, the previous studies have shown the applicability of several herbal plants as feed additives in poultry and swine industry (Fontamillas et al, 2019;Settle et al, 2014;Windisch, Schedle, Plitzner, & Kroismayr, 2008).…”

Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water

“…The active component in A. gigas Nakai root extracts (ARE) is decursin or decursinol angelate. Purification or extraction of the active compounds may increase the efficacy of ARE 8 …”

“…Purification or extraction of the active compounds may increase the efficacy of ARE. 8 The importance of water as a material for functional is increasing, not only as a role of quenching thirst. Mineral-rich water is abundant in minerals and nutrients derived from volcanic rocks.…”