2017
DOI: 10.1155/2017/8525912
|View full text |Cite
|
Sign up to set email alerts
|

Effects ofBacillusSerine Proteases on the Bacterial Biofilms

Abstract: Serratia marcescens is an emerging opportunistic pathogen responsible for many hospital-acquired infections including catheter-associated bacteremia and urinary tract and respiratory tract infections. Biofilm formation is one of the mechanisms employed by S. marcescens to increase its virulence and pathogenicity. Here, we have investigated the main steps of the biofilm formation by S. marcescens SR 41-8000. It was found that the biofilm growth is stimulated by the nutrient-rich environment. The time-course exp… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
18
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 39 publications
(18 citation statements)
references
References 47 publications
0
18
0
Order By: Relevance
“…Although these proteases have been thought to play roles in nutrient acquisition from the surrounding environment, our results suggest that these degradative enzymes may also play roles in competition within biofilms. Indeed, several proteases were previously shown to disrupt biofilms of heterologous bacteria by degrading critical protein components in biofilms [63, 64, 65, 66]. Simultaneously producing multiple antibiotics and degradative enzymes within biofilms affords B .…”
Section: Discussionmentioning
confidence: 99%
“…Although these proteases have been thought to play roles in nutrient acquisition from the surrounding environment, our results suggest that these degradative enzymes may also play roles in competition within biofilms. Indeed, several proteases were previously shown to disrupt biofilms of heterologous bacteria by degrading critical protein components in biofilms [63, 64, 65, 66]. Simultaneously producing multiple antibiotics and degradative enzymes within biofilms affords B .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the biofilm multicellular structure is compromised with a modality that does not affect cellular functions crucial for microbial survival [14]. For example, glycosidases as well as proteases or deoxyribonuclease have been reported to degrade bacterial matrix [16,17,18,19].…”
Section: Introductionmentioning
confidence: 99%
“…High efficacy of treatment with subtilisin-like protease and glutamyl endopeptidase for biofilm removal has been demonstrated. Enzymatic processing led to the degradation of EPS components and significant destruction of biofilms ( Mitrofanova et al, 2017 ).…”
Section: The Use Of Microbial Enzymes In Medicinementioning
confidence: 99%