Effects of Chimonanthus nitens Oliv. Leaf Extract on Glycolipid Metabolism and Antioxidant Capacity in Diabetic Model Mice

Abstract

The paper investigated the antihyperglycemic and antihyperlipidemic efficacy and antioxidant capacity of Chimonanthus nitens Oliv. leaf extract (COE) in combination of high-glucose-fat diet-fed and streptozotocin-induced diabetic model mice. Various physiological indexes in diabetic model mice were well improved especially by oral administration of high dose of COE; the results were listed as follows. Fast blood glucose (FBG) level and serum triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDLC), and malondialdehyde (MDA) as well as MDA in liver were significantly reduced; fasting serum insulin (FINS) and insulin sensitivity index (ISI) were both increased; high-density lipoprotein cholesterol (HDLC) in serum was significantly increased; total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in serum and liver were apparently enhanced; liver coefficient (LC), liver transaminase, and alkaline phosphatase (ALP) were decreased. Furthermore, pancreas islets and liver in diabetic model mice showed some extend of improvement in morphology and function after 4 weeks of COE treatment. In consequence, COE was advantageous to regulate glycolipid metabolism and elevate antioxidant capacity in diabetic model mice. Thus, the present study will provide a scientific evidence for the use of COE in the management of diabetes and its related complications.

Investigation of Chemical Composition, Antioxidant Activity, and the Effects of Alfalfa Flavonoids on Growth Performance

“…Nevertheless, it has been reported that synthetic antioxidants are restricted due to their potential carcinogenicity [3]. Hence, there has been more and more interests in developing and using natural, effective, safe, and multiple biological antioxidants to replace synthetic antioxidants in many industries, such as natural plant polyphenol compounds [4,5]. The flavonoids are a group of polyphenol compounds with a basic structure of C6-C3-C6 carbon skeleton and known for powerful antioxidant capacities based on their polyhydroxyl structures [6,7].…”

Physical Map of FISH 5S rDNA and (AG3T3)3 Signals Displays Chimonanthus campanulatus R.H. Chang & C.S. Ding Chromosomes, Reproduces its Metaphase Dynamics and Distinguishes Its Chromosomes

“…Studies on Ch. nitens have focused on its calycanthine, chimonanthine, coumarins, flavonoids, phenolic acids, terpenoids, and volatile oils [45,46,47] and their pharmacologies (anti-inflammatory properties [48], antihyperglycaemic [49] and antihyperlipidaemic efficacies, and antioxidant capacity [50], inhibitory α-glucosidase activity [51], and toxicity [52]), phylogeography [45,53], and fingerprints [54,55]. Studies on Ch.…”

Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring

“…These results are consistent with the findings from our previous studies showing that MA inhibited DPPH (a marker of nitrogen radical) in vitro and LPS-induced hepatic NO content in rats ( 13 , 26 ). SOD, GSH-Px, and CAT play an important role in preventing O 2 − and H 2 O 2 -induced oxidative damage ( 27 ). MDA is one of the biomarker of lipid peroxidation.…”