Effects of <i>CYP2D6*10, CYP3A5*3, CYP1A2*1F</i>, and <i>ABCB1</i> C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects

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Effects of CYP2D610, CYP3A53, CYP1A21F, and ABCB1* C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects

Abstract: The disposition of flecainide appeared to be influenced by the CYP3A53 and possibly the CYP1A21F polymorphisms, particularly in subjects with CYP2D6 variant alleles.

Cited by 9 publications

References 18 publications

Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects

Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects

Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes

Late positive flecainide challenge test for Brugada syndrome

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Effects of CYP2D6*10, CYP3A5*3, CYP1A2*1F, and ABCB1 C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects

Abstract: The disposition of flecainide appeared to be influenced by the CYP3A5*3 and possibly the CYP1A2*1F polymorphisms, particularly in subjects with CYP2D6 variant alleles.

Cited by 9 publications

References 18 publications

Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects

Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects

Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes

Late positive flecainide challenge test for Brugada syndrome

Contact Info

Product

Resources

About

Effects of CYP2D610, CYP3A53, CYP1A21F, and ABCB1* C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects

Abstract: The disposition of flecainide appeared to be influenced by the CYP3A53 and possibly the CYP1A21F polymorphisms, particularly in subjects with CYP2D6 variant alleles.