Effects ofSalvadora persicaExtract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats

Abstract

A total of 24 rats were divided into 4 groups: control, stress, extract alone, and stress + extract (n = 6 each), for total 21 days of treatment. The immobilization stress was induced in rats by putting them in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Rats were postorally treated with Salvadora persica at a dose of 900 mg/kg body weight via intragastric intubations. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples with determination of vital organs weights. The vital organ weights were not significantly affected in stressed rats as compared to control rats. Compared to the control group, the stress treated group showed significances in several hematological parameters, including decreases in WBC, RBC, and PLT counts. Furthermore, in comparison to the control group, the stress group showed significantly increased blood glucose, serum total cholesterol, LDL-cholesterol, and triacylglycerols levels and decreased HDL-cholesterol level. The hematological and biochemical parameters in the stress + extract treated group were approximately similar to control group. The SP extract restored the changes observed following stress treatment.

Salvadora persica protects mouse intestine from eimeriosis

“…The high therapeutic potential of S. persica reflects the anti-inflammatory (EZMIRLY et al, 1979) and antioxidant (MOHAMED & KHAN, 2013) activities of the plant extract components. Ramadan and Alshamrani (RAMADAN & ALSHAMRANI, 2015) described the potential anti-stress activity of S. persica aqueous extract. Salvadora persica inhibited stress-induced abnormalities in hematological parameters, glucose level, and lipid profile, indicating its protective effect against stress.…”

The Anti-Stress Effect of Mentha arvensis in Immobilized Rats

“…Stress has been a significant impact on human health globally, causing several psychosomatic disorders [ 1 ] and pathological conditions, like coronary artery diseases, cancer, and diabetes mellitus, [ 2 ] and accompanying body-weight loss. The neuroendocrine damages in response to frequent stresses are managed by both the sympathetic nervous system and the hypothalamus-pituitary-adrenal (HPA) axis, which complements the release stress factors such as serotonin, β-endorphin, corticotropin-releasing dopamine, glutamate, and norepinephrine, adrenocorticotropic hormones in the central nervous system (CNS), and the secretion of glucocorticoids in plasma [ 3 , 4 , 5 ].…”

“…The evidence stated that acute stress is associated with the release of oxidative free radicals that facilitate the phosphorylation of mitogen-activated protein kinases (MAPK) cascade in the hippocampus of stress rats [ 11 , 12 ]. Immobilization is a suitable and easy method to cause physical stress, which leads to restricting mobility and aggression in an animal model [ 2 ] and is widely accepted for studying stress-induced alterations [ 13 ].…”

Efficiency of Probiotic in Immobilized Rats Through Involvement of the Antioxidant and Anti-inflammatory Systems

“…tress is known as a factor that causes negative effects on general physiology and leads psychology [1], heart and causes diabetes and loss weight [2]. It also causes faulted working memory, anxious and depression [3].…”

“…In addition, stress is related with increased oxidative stress that stimulates phosphorylation of mitogen-activated protein kinases in animal models [8,9]. Immobilization is type of physical stress that limits mobilization and increases aggression in the animal model [2] and is also used to study the stress-induced changes [10].…”