Effects of IGF-I bioavailability on bovine preantral follicular development in vitro

Thomas, Fiona H; Campbell, Bruce; Armstrong, David G.; Telfer, Evelyn E.

doi:10.1530/rep-06-0382

Cited by 73 publications

(56 citation statements)

References 38 publications

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“…For instance, 20 ng/ml human recombinant IGF1 and 1 ng/ml Long R3 IGF1, which have a 1000-fold reduced affinity for IGFBPs (Francis et al 1992), promote antrum formation and increase oocyte diameter in preantral follicles (Gutierrez et al 2000, Itoh et al 2002. By contrast, 5-50 ng/ml Long R3 IGF1 and 1000 ng/ml human recombinant IGF1 induced detrimental effects on oocyte morphology, size and number of granulosa cell layers in the same category of follicles (McCaffery et al 2000, Thomas et al 2007. In small antral follicles, 1000 ng/ml human recombinant IGF1 can increase follicle diameter (165-215 mm), but not in medium-sized (216-280 mm) and large antral follicles (281-380 mm; Walters et al 2006).…”

Section: Introductionmentioning

confidence: 93%

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

Velazquez

Zaraza²,

Oropeza³

et al. 2009

Reproduction

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IGF1 plays an important role in bovine follicular growth, acquisition of oocyte competence and embryo viability. Current data also indicate a critical role for IGF1 in both the ovarian response and the embryo yield following the superovulatory treatments. IGF1 can have either positive or negative effects on embryo viability which is related to the concentration of IGF1 induced by superovulation treatment. These effects impact either on oocyte competence or directly on the embryo. Concentrations in the physiological range appear to result in the production of higher quality embryos, mainly due to the mitogenic and the anti-apoptotic activities of IGF1. However, high superovulatory responses are associated with decreased embryo viability and a concomitant increase in apoptosis. Studies in mice suggest that this increase in apoptosis is related to the downregulation of the IGF1 receptor in the embryo associated with high IGF1 concentrations. Strategies capable of controlling the IGF1 concentrations could be one approach to improve superovulation responses. A range of possible approaches for research within the IGF system in gonadotrophin-stimulated cattle is discussed in this review, including the possible use of superovulated female cattle as an alternative animal experimental model for research on reproductive disorders in humans associated with abnormal IGF1 concentrations.

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Section: Introductionmentioning

confidence: 93%

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

Velazquez

Zaraza²,

Oropeza³

et al. 2009

Reproduction

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“…The increase in the follicular diameter due to the stimulation by IGF-I, in preantral follicles, has been shown in other species, like rats (Zhao et al, 2001) and cattle (Thomas et al, 2007). However, although it has a stimulatory effect on early follicular growth, McCaffery et al (2000) highlighted the importance of the regulation mechanism, since, in cattle, inadequate exposure of preantral follicles to IGF-I has a negative effect on oocyte development.…”

Section: Ultrastructural Features Of Caprine Preantral Folliclesmentioning

confidence: 95%

Association between insulin-like growth factor-I, thyroxine and follicle stimulating hormone on the survival and in vitro development of caprine preantral follicles

Costa

Pereira

et al. 2014

RBCV

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AbstratThe aim of this study was to investigate the influence of the interaction between follicle stimulating hormone obtained from Human Pituitary (hFSH; 10 ng/mL), Insulin-like Growth Factor Type 1 (IGF-I; 100 ng/mL) and thyroxine (T 4 ; 10, 20 ng/mL) on survival, activation and growth of preantral follicles (PAF) cultured in vitro. Fragments of ovarian cortex collected from 17 nonpregnant adult goats underwent different treatments that included α-MEM + medium, IGF-I, hFSH, T 4 and were processed for classic histology and transmission electron microscopy. The results showed a reduction in the percentage of normal follicles, after one and seven days of culture in media α-MEM + (cultured control), T 4 (10)/IGF-I, T 4 (20)/IGF-I/hFSH and in media α-MEM + , IGF-I/hFSH, T 4 (20)/IGF-I/hFSH, T 4 (20)/IGF-I/hFSH , when compared to the non-cultured control. However, the medium containing T 4 (20)/hFSH showed a follicular survival rate higher than the other treatments, when cultured for seven days. It was also observed that the follicular diameter did not change when cultured in this medium, when compared to the control (non-cultured). The ultrastructural analysis confirmed the integrity of follicles cultured in a medium containing T 4 (20)/hFSH. In conclusion, the medium containing T 4 (20)/hFSH showed the best results, when evaluating the survival, growth and ultrastructural aspects of caprine preantral follicles cultured in vitro.Keywords: Caprine, hormone, in vitro culture, preantral follicles, ultrastructural analysis. ResumoO objetivo deste estudo foi investigar a influência da interação entre o Hormônio Folículo Estimulante obtido da pituitária Humana (hFSH; 10 ng/mL), Fator de Crescimento Semelhante a Insulina Tipo 1 (IGF-I; 100 ng/mL) e Tiroxina (T 4 ; 10, 20 ng/mL) na sobrevivência, ativação e crescimento de folículos pré-antrais cultivados in vitro. Fragmentos do córtex ovariano coletados a partir de 17 cabras adultas não gestantes foram submetidos a diferentes tratamentos que incluíam meio α-MEM +, IGF-I, hFSH, T 4 e em seguida foram processados para histologia clássica e microscopia eletrônica de transmissão. Os resultados demonstraram uma redução no percentual de folículos normais, após um e sete dias de cultivo nos meios α-MEM + (controle cultivado), T 4 (10)/IGF-I, T 4 (20)/IGF-I/hFSH e nos meios α-MEM + , IGF-I/hFSH, T 4 (20)/IGF-I/hFSH, T 4 (20)/IGF-I/hFSH , quando comparados ao controle não cultivado. Entretanto, o meio contendo T 4 (20)/hFSH apresentou taxa de sobrevivência folicular superior aos demais tratamentos, quando cultivado por sete dias. Observou-se, ainda, que o diâmetro folicular quando cultivado neste meio não se alterou, quando comparado ao controle (não cultivado). As análises ultraestruturais confirmaram a integridade de folículos cultivados em meio contendo T 4 (20)/hFSH. Em conclusão, o meio com T 4 (20)/hFSH apresentou os melhores resultados, quando se avaliou sobrevivência, crescimento e aspectos ultraestruturais de folículos pré-antrais de caprinos cultivados in vitro.Palavras-c...

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“…The IGFBPs are present in biological fluids and act by inhibiting or potentiating the action of the two IGFs (IGF-I and IGF-II) in target cells (Monget et al, 2002). The regulation of the bioavailability of IGF-I by IGFBPs is necessary for the co-ordinated development in vitro, of the bovine oocyte and follicle (Thomas et al, 2007). The receptors for insulin and IGF-I belong to the same subfamily of receptor tyrosine kinases with two extracellular α-subunits and two trans-membrane β-subunits.…”

Section: Metabolic Hormonesmentioning

confidence: 99%

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

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The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

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Effects of IGF-I bioavailability on bovine preantral follicular development in vitro

Cited by 73 publications

References 38 publications

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

The role of IGF1 in the in vivo production of bovine embryos from superovulated donors

Association between insulin-like growth factor-I, thyroxine and follicle stimulating hormone on the survival and in vitro development of caprine preantral follicles

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

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