Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation.

Abstract

The present study demonstrates the graded effect of in vitro corticosteroids (CSs) on

Effect of Immunosuppressive Drugs on Humoral Allosensitization after Kidney Transplant

“…55 High concentrations of corticosteroids are also likely to interfere with Fc g-receptor signaling, including the inhibitory Fc g-RIIb, which acts as a key negative modulator of B cell function and controls bone marrow plasma cell apoptosis. 56 The effect of a standard maintenance dose of corticosteroid therapy on human B cells was studied in a seminal in vitro study by Cupps et al 57 in the mid-1980s. Early events in B cell activation, such as anti-IgM-induced B cell activation and proliferation, are profoundly suppressed by corticosteroids.…”

“…Early events in B cell activation, such as anti-IgM-induced B cell activation and proliferation, are profoundly suppressed by corticosteroids. 57 To be effective, the corticosteroids have to be present in the culture during the first 24 hours, suggesting a drug-induced modulation of an early event. 57 Over the last decades, several attempts have been made to develop steroidsparing strategies to avoid their important deleterious side effects.…”

“…57 To be effective, the corticosteroids have to be present in the culture during the first 24 hours, suggesting a drug-induced modulation of an early event. 57 Over the last decades, several attempts have been made to develop steroidsparing strategies to avoid their important deleterious side effects. No increased risk in sensitization has been reported in patients without corticosteroids in a prospective single-center study on kidney transplantation 58 and two retrospective studies on liver transplantation.…”

Immunoglobulin production in vitro in major depression: A pilot study on the modulating action of endogenous cortisol

“…Glucocorticoids exert inhibiting effects on the expression of immune response antigen on the surface, which plays a role in the interaction of B cells with T cells (McMillan et al 1988), on the synthesis of cytokines---e.g., interleu-kin-1 (IL-1), interleukin-2 (II-2), and interleukin-6 (IL-6) (Snyder and Unanue 1982;Arya et al 1984;Staruch and Wood 1985;Woloski et al 1985;Grabstein et al 1986) and on cytokine receptors (Reed et al 1986;Akahoshi et al 1988). Furthermore, glucocorticoids induce suppression of B cell activation and proliferation (Bowen and Fauci 1984;Cupps et al 1985) and T cell proliferation (Gillis et al 1979). They exhibit a differential effect on the function ofT helper and T suppressor cells (Bradley and Mishell 1981).…”

Comparación de infecciones por Pneumocystis jiroveci en pacientes con y sin diagnóstico de infección por VIH

“…VIH/SIDA principalmente afectada la producción de anticuerpos 16,18 . Las alteraciones anteriormente descritas, por lo tanto, podrían implicar una respuesta inmunológica e inflamatoria diferente, con una presentación clínica y una evolución distinta en ambas poblaciones 19 .…”