Effects of Inactivating HTLV-Iii on Laboratory Tests

Ball, M.J.; Bolton, F. G.; Gow, A.; Fallon, R. J.

doi:10.1016/s0140-6736(85)90201-6

Cited by 5 publications

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“…2 While there has been considerable doubt expressed about the efficacy of this regime.l" the recommendations by the Center for Disease Control, Atlanta, are still used by many clinical laboratories to reduce the risk of accidental exposures to laboratory workers. There have been numerous publications assessing the effect of this heat inactivation procedure on the results of routine biochemical.t" endocrine,6,9,IJ-15 therapeutic drug 8 • 1 b-17 and haematological tests, 12,18 but only limited investigation of its effects on specific proteins. We have studied the effect of heat treatment on the analysis of various specific serum proteins and tumour markers commonly measured by diagnostic laboratories.…”

Section: Additional Key Phrases: Reduced Serum Protein Concentration;mentioning

confidence: 99%

Effect of Heat Inactivation of HIV on Specific Serum Proteins and Tumour Markers

1990

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The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56°C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for α-1-antitrypsin, β-2-microglobulin, IgE, fibrinogen, C***1-esterase inhibitor and CA125. Statistical, but not clinically significant, changes were observed for α-1-acid glycoprotein, C3, haptoglobin, IgA, IgG, IgM and transferrin. A significant decrease in the α-1 band was observed on protein electrophoresis.

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Section: Additional Key Phrases: Reduced Serum Protein Concentration;mentioning

confidence: 99%