Effects of increased viscosity on micromixing in rotor–stator spinning disk reactors

Martinez, Arturo Neissen Manzano; Chaudhuri, Arnab; Assirelli, Melissa; Schaaf, J. van der

doi:10.1016/j.cej.2021.134292

Cited by 22 publications

(18 citation statements)

References 62 publications

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“…Rotorstator spinning disc technology is a novel multiphase reactor that has the ability to improve micromixing, increasing gas-liquid, liquid-liquid and liquid-solid mass transfer rates significantly compared to conventional PB columns. [90][91][92][93][94][95][96][97] Spinning disc technology also intensifies the rate of heat transfer in a process. Spinning disc reactors (SDR) have great potential in processes that are mass-transfer and heat-transfer limited, such as carbon capture, polymerization and crystallization.…”

Section: Rotating Disc For Co 2 Capture Applicationmentioning

confidence: 99%

Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture

Joel

Isa

2022

J of Chemical Tech & Biotech

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A global net zero target by mid-century and keeping the maximum global temperature rise to below 1.5 °C was agreed by nearly 200 nations at the 26th UN Climate Change Conference of the Parties. The Intergovernmental Panel on Climate Change advises that emission cuts by 45% are needed by 2030 in order to maintain the global temperature rise below the 1.5 °C target. To achieve this target, it is necessary to investigate technological options that are economically viable and globally acceptable for commercial deployment. This review paper looks at the new technologies needed to reduce CO 2 emission and to motivate commercial deployment, considering that the commercial deployment of CO 2 has been slowed down as a result of high capital and operating expenses which invariably increase the cost of energy. The paper presents a review on early years of process intensification technologies as well as a discussion on potential new process intensification options for CO 2 capture, with suggestions on how to modify those technologies for suitable application to solvent-based carbon capture. The work further discusses current process intensification technologies used for CO 2 capture applications. Solvent developments for enhancing CO 2 capture also are discussed as they contribute to cutting down the sizes of the units as well as decreasing the cost of regeneration which leads to reduction in capital and operating costs. A process flow diagram using a mop fan for capture of CO 2 from buildings is proposed. In addition, a new flow diagram is proposed for using loop reactor technology to capture CO 2 from large point sources, and finally a new process diagram using rotating packed bed absorber combined with sono-assisted regenerator is presented for improved performance of CO 2 capture technology. Recommendations on these diagrams are made to help ensure transition toward the net zero target.

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Section: Rotating Disc For Co 2 Capture Applicationmentioning

confidence: 99%

Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture

Joel

Isa

2022

J of Chemical Tech & Biotech

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“…Nevertheless, operational conditions including high viscosity μ (much larger than water, >4 mPa·s) and large R (>6) exist widely in industry, indicating that most micromixers may not satisfy the mixing demands in such circumstances. Achieving ideal mixing of highly viscous fluids is challenging due to poor fluidity and slow molecular diffusion, − which is reflected in the wide molecular weight distribution in many polymerization processes − and poor product quality in the synthesis of bromobutyl rubber . The deterioration of mixing quality is extraordinarily remarkable in passive micromixers, where chaotic advection can hardly be activated and pressure drop rises sharply .…”

Section: Introductionmentioning

confidence: 99%

Micromixing Performance and Residence Time Distribution in a Miniaturized Magnetic Reactor: Experimental Investigation and Machine Learning Modeling

Chen

Deng

Luo

2023

Ind. Eng. Chem. Res.

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Miniaturization of mixers is a hot topic in process intensification, but efficient mixing at operational conditions with relatively large viscosity μ and large flow rate ratio R between two mixed solutions is still a great challenge for micromixers. Herein, a miniaturized magnetic reactor (MMR) is developed, and its micro- and macromixing performances are characterized by the Villermaux/Dushman reaction and residence time distribution experiments, respectively. The results show that the miniaturization of the premixing unit and the stirred unit is vital. By arranging the stirred units in series, the MMR is effective in reducing axial dispersion, intensifying mixing at operational conditions with large μ and R and achieving efficient energy utilization without introducing extra energy input. The micromixing time t m in the optimized MMR ranges from 0.24 to 1.42 ms when 4.72 mPa·s < μ < 73.30 mPa·s and 8 < R < 20, indicating superior micromixing performance. Moreover, machine learning models are established and compared for predicting t m with excellent accuracy and guiding mixer design, and the SHAP method is adopted for model interpretation.

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“…The development of effective mixing conditions in the batch mode requires experimenting with different aspects of the manufacturing process, which includes the stirring components as well as the reactor design . Mixing effects are often discussed in process development, and improved, more practical mixers have been developed in recent years . In Mae et al.’s paper on scaling effects, the order of magnitude difference for mixing in vessels of different sizes is described.…”

Section: Introductionmentioning

confidence: 99%

Process Intensification of a Napabucasin Manufacturing Method Utilizing Microflow Chemistry

2023

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Microflow chemistry is one of the newest and most efficient technologies used today for the safe and effective production of medicines. In this paper, we show the use of this technology in the development of a manufacturing method for napabucasin, which has potential in the treatment of colorectal and pancreatic cancers. In conventional “batch-type” reactor systems, the generation of side products can be controlled with traditional techniques such as reagent reverse-addition and temperature control. However, there is a limitation to which the yield and purity can be improved by these methods, as both are constrained by the efficiency of heat/mass transfer. Applying microflow chemistry technology alters the parameters of the constraint through the use of precise mixing in a microchannel, which offers increased possibility for improving yields and process intensification of the napabucasin process. Reported herein is a proof-of-concept study for the scale-up production of napabucasin using microflow chemistry techniques for manufacturing at the kilogram scale.

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Effects of increased viscosity on micromixing in rotor–stator spinning disk reactors

Cited by 22 publications

References 62 publications

Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture

Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture

Micromixing Performance and Residence Time Distribution in a Miniaturized Magnetic Reactor: Experimental Investigation and Machine Learning Modeling

Process Intensification of a Napabucasin Manufacturing Method Utilizing Microflow Chemistry

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Effects of increased viscosity on micromixing in rotor–stator spinning disk reactors

Cited by 22 publications

References 62 publications

Novelty in fossil fuel carbon abatement technologies in the 21st Century: post‐combustion carbon capture

Novelty in fossil fuel carbon abatement technologies in the 21st Century: post‐combustion carbon capture

Micromixing Performance and Residence Time Distribution in a Miniaturized Magnetic Reactor: Experimental Investigation and Machine Learning Modeling

Process Intensification of a Napabucasin Manufacturing Method Utilizing Microflow Chemistry

Contact Info

Product

Resources

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Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture

Novelty in fossil fuel carbon abatement technologies in the 21^st Century: post‐combustion carbon capture