Effects of induced ovulation by pregnant mare's serum and human chorionic gonadotropin on the sex ratio of mouse fetuses

Sakai, Nobuyuki; Endo, Akira

doi:10.1002/mrd.1120160406

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…In addition, the sexually dimorphic developmental inequalities previously reported were encountered in these experiments. Similarly, these data compare favorably with laterally asymmetric sex ratio distributions reported in the rabbit [1], mouse [2,36], and Mongolian gerbil [11,30,37] and those detected in the other experiments of this study. However, the mechanism underlying the difference in the sex ratio distortion found in IVF-derived embryos generated in oocytes from the left but not from the right ovary remains unknown.…”

Section: Discussionsupporting

confidence: 90%

Sex Ratio of Bovine Embryos and Calves Originating from the Left and Right Ovaries1

Hylan

Giraldo

Carter

et al. 2009

Biology of Reproduction

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An asymmetric distribution of the sexes within the left and right uterine horns has been described in multiple species. A series of experiments were conducted to evaluate the sex ratio (% male) of calves gestated in the left and right uterine horns, as well as the sex ratio of embryos originating from the left and right ovaries of cattle. The sex ratio of calves gestated in the right uterine horn of naturally mated cows was significantly higher compared with the sex ratio of calves gestated in the left uterine horn. In addition, the sex ratio of the left and right uterine horns differed significantly from parity. The sex ratio of embryo transfer calves born following transfer to the left and right uterine horns was not significantly different. Additionally, the proportion of male embryos collected from the right uterine horns was significantly greater than from the left uterine horns of superovulated cows. The sex ratio of embryos collected from the left and right uterine horns of unilaterally ovariectomized cows was not significantly different. However, more female than male embryos were produced when left ovary oocytes fertilized in vitro. In conclusion, the results of these experiments demonstrate that a significantly greater proportion of males are gestated in the right uterine horn of cattle and a greater proportion of females in the left. Additionally, the data indicate that sex-specific selection pressure may be applied to embryos by ovarian factors rather than by the uterine environment.

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Section: Discussionsupporting

confidence: 90%

Sex Ratio of Bovine Embryos and Calves Originating from the Left and Right Ovaries1

Hylan

Giraldo

Carter

et al. 2009

Biology of Reproduction

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Pregnant mares' serum gonadotropin source influences fertilization and fresh or thawed embryo development, but the effect is genotype specific

Schmidt¹,

Monfort²,

Wildt³

1989

Gamete Research

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The influence of the source of pregnant mares' serum gonadotropin (PMSG) on the number, quality, and in vitro development of mouse embryos before and after freezing was evaluated among three genotypes: N:NIH(S), C57BL/6N, and C3H/HeN-MTV-Immature females were given PMSG from one of five commercial sources. Following collection (116 hr later), embryos were evaluated for stage of development, and four- to eight-cell embryos were pooled within genotype and assigned to standardized fresh or freeze-thaw culture trials. Different PMSG sources stimulated the production of different numbers of total embryos (P less than 0.05) but not necessarily more embryos suitable for freezing. Differences in embryo production among genotypes indicated that absolute embryo numbers using a single mouse genotype may not accurately reflect the potency of a specific gonadotropin source. The PMSG source also affected the ability of an embryo to survive in culture either immediately after collection or after frozen storage. The effect, however, was genotype specific, with some mouse strains being relatively insensitive to PMSG source, whereas gonadotropin source played a major role in determining in vitro viability in others. Development rates for freshly collected embryos differed, often inconsistently, from those of thawed embryos regardless of the PMSG source used, demonstrating that fresh embryo development cannot be used to estimate expected post-thaw survival. In vitro development of thawed embryos is influenced not only by genotype, but also the source of the gonadotropin used to promote follicular development and oocyte maturation. These findings may explain, in part, the wide variation in embryo viability and culture rates reported among laboratories and intraspecies animal populations.

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Multiple factors determine the sex ratio of postpartum-conceived norway rat litters

Bacon

McClintock

1994

Physiology & Behavior

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Effects of induced ovulation by pregnant mare's serum and human chorionic gonadotropin on the sex ratio of mouse fetuses

Cited by 6 publications

References 15 publications

Sex Ratio of Bovine Embryos and Calves Originating from the Left and Right Ovaries1

Sex Ratio of Bovine Embryos and Calves Originating from the Left and Right Ovaries1

Pregnant mares' serum gonadotropin source influences fertilization and fresh or thawed embryo development, but the effect is genotype specific

Multiple factors determine the sex ratio of postpartum-conceived norway rat litters

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