Effects of influenza vaccination in HIV-infected adults: a double-blind, placebo-controlled trial

Tasker, Sybil A.; O’Brien, William A.; Treanor, John J.; Weiss, Peter J.; Olson, Patrick E.; Kaplan, Andrew H.; Wallace, Mark R.

doi:10.1016/s0264-410x(97)00275-2

Cited by 120 publications

(90 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Annual influenza vaccination for adults infected with HIV is recommended by the CDC and the IDSA, although this recommendation has not received universal support [50]. The only clinical trial showed a 20% absolute reduction in the risk of respiratory symptoms and 100% protection against laboratory-confirmed symptomatic influenza among HIV-infected patients receiving the influenza vaccine compared with those receiving placebo [133]. Two systematic reviews concluded that influenza vaccination of adults infected with HIV might be effective despite variable antibody responses [134,135].…”

Section: Viral Infectionsmentioning

confidence: 99%

Pulmonary infections in HIV-infected patients: an update in the 21st century

Benito¹,

Moreno²,

Miró³

et al. 2011

Eur Respir J

176

216

View full text Add to dashboard Cite

From the first descriptions of HIV/AIDS, the lung has been the site most frequently affected by the disease. Most patients develop a pulmonary complication during the history of HIV infection, mainly of infectious aetiology.Important changes in the epidemiology of HIV-related pulmonary infections have occurred. Overall, prescription of Pneumocystis jirovecii prophylaxis and the introduction of highly active antiretroviral therapy (HAART) are the main causes.Currently, the most frequent diagnosis in developed countries is bacterial pneumonia, especially pneumococcal pneumonia, the second most frequent cause is Pneumocystis pneumonia and the third is tuberculosis. However, in Africa, tuberculosis could be the most common pulmonary complication of HIV.Pulmonary infections remain one of the most important causes of morbidity and mortality in these patients, and the first cause of hospital admission in the HAART era. Achieving an aetiological diagnosis of pulmonary infection in these patients is important due to its prognostic consequences.

show abstract

Section: Viral Infectionsmentioning

confidence: 99%

Pulmonary infections in HIV-infected patients: an update in the 21st century

Benito¹,

Moreno²,

Miró³

et al. 2011

Eur Respir J

176

216

View full text Add to dashboard Cite

show abstract

“…[8] Data have also shown that those with HIV infection have a longer duration and increased severity of illness, compared to the general population. [240][241][242][243] Cancer patients and transplant recipients are also at high risk of infection with influenza virus, including nosocomial acquisition of influenza. [244][245][246] In addition, immunosuppressed individuals are at elevated risk of developing an antiviral resistant influenza infection in response to an antiviral treatment regimen; high rates of resistant infection have been documented in this group for seasonal [247][248][249] and influenza A(H1N1)pdm virus.…”

Section: Disease Burdenmentioning

confidence: 99%

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Rondy¹,

Launay

Puig-Barberà

et al. 2015

Eurosurveillance

View full text Add to dashboard Cite

show abstract

“…A redução nos níveis de linfócitos T CD4+ após a vacinação contra influenza, observada em alguns estudos 8,39 , não se repetiu na presente série, quando se analisaram os níveis percentuais. A comparação da resposta dos linfócitos T CD4+ após a vacinação contra influenza, entre alguns estudos realizados com pacientes adultos e a presente série, pode ser observada na Tabela 4.…”

Section: Figura 3 -unclassified

Influenza vaccination in HIV infected children: immunologic and viral load changes

Carvalho¹,

Dutra²,

Tonelli³

2003

J Pediatr (Rio J)

View full text Add to dashboard Cite

ResumoObjetivo: verificar se a vacinação contra influenza em crianças infectadas pelo HIV aumentaria a carga viral e reduziria os linfócitos T CD4+, conseqüentes à ativação da imunidade com antígenos dependentes do linfócito T.Métodos: estudo prospectivo descritivo, com 51 crianças infectadas pelo HIV, vacinadas contra influenza em 1999, em Florianó-polis, Brasil. Coletaram-se amostras de sangue no dia da vacinação, 14 a 20 e 60 a 90 dias após, para determinação dos níveis da carga viral do HIV e de linfócitos T CD4+. A análise estatística constou dos testes ANOVA de Friedman, t de Student para amostras dependentes, Correção de Bonferroni e Wilcoxon.Resultados: a média de idade foi de 6,08 anos (1 a 12,9 anos). A mediana da contagem de linfócitos T CD4+ no dia da vacinação e nos dois momentos subseqüentes foi de 789, 645 e 768 células/mm 3 . Observou-se redução significativa na contagem de linfócitos T CD4+ entre a primeira e a segunda determinação (p=0,0001, teste de Wilcoxon), o mesmo não ocorrendo entre a primeira e a terceira . Não houve diferença significativa nas porcentagens de linfócitos T CD4+ entre a primeira aferição e a segunda. A mediana da carga viral em log 10 cópias/ml foi de 4,38, 4,30 e 4,25, nos três momentos, respectivamente. Oito de 44 pacientes (18,2%) evidenciaram elevação >0,5 log 10 cópias/ml na carga viral entre a primeira e segunda aferição, quatro dos quais retornaram aos níveis basais na terceira.Conclusões: não se observou alteração significativa na porcentagem de linfócitos T CD4+, apesar de ocorrer elevação da carga viral do HIV, de forma transitória, após vacinação contra influenza. Recomenda-se uma certa prudência na aplicação da vacina contra influenza para as crianças com condição clínica e imunológica não estável, principalmente se essas não estiverem sob terapêutica antiretroviral eficaz.J Pediatr (Rio J) 2003;79(1):29-40: influenza, vacina contra influenza, infecção pelo HIV, carga viral do HIV, níveis de linfócitos T CD4+. AbstractObjective: to identify whether influenza immunization in HIV infected children could increase HIV viral load and decrease CD4+ lymphocytes count as a consequence of the response induced by a T cell-dependent antigen.Methods: prospective, descriptive study, with 51 HIV infected children, vaccinated against influenza in 1999, in Florianópolis, Brazil. Blood samples were collected at three different moments: on the immunization day; between 14 and 20 days later; between 60 and 90 days later. Plasma levels of HIV viral load and CD4+ lymphocytes count were determined. Friedman ANOVA test, Student t-test for dependent samples, Bonferroni correction, and Wilcoxon matched test were performed for statistic analysis.

show abstract

Effects of influenza vaccination in HIV-infected adults: a double-blind, placebo-controlled trial

Cited by 120 publications

References 27 publications

Pulmonary infections in HIV-infected patients: an update in the 21st century

Pulmonary infections in HIV-infected patients: an update in the 21st century

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Influenza vaccination in HIV infected children: immunologic and viral load changes

Contact Info

Product

Resources

About