Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to adenosine 5′monophosphate in asthmatic patients

Efficacy and safety of ciclesonide once daily and fluticasone propionate twice daily in children with asthma

“…This needs further assessment in long-term studies including other safety parameters. The lack of effect of ciclesonide on cortisol excretion in this study corroborates the findings in other studies in children, 8,28 as well as adults, [14][15][16][17] in which minimal effects on the hypothalamic-pituitary-adrenal-axis were seen. Both drugs were well tolerated in the study and the AE rates were low, with similar profiles for the two drugs.…”

“…[8][9][10][11][12][13] Furthermore, ciclesonide was well tolerated in these populations. 8,9,[14][15][16][17][18][19] An earlier comparison of ciclesonide versus fluticasone propionate in children, using only one dose of each drug indicated similar efficacy of the two drugs. 9 To further investigate the efficacy and safety of ciclesonide, the present study included bronchial hyperresponsiveness and definitions of asthma control using combinations of outcome measures, in addition to more traditional measures.…”

Ciclesonide is more effective than budesonide in the treatment of persistent asthma

“…Previous studies have shown that ciclesonide does not induce cortisol suppression at daily doses as high as 1280 µg. [28,29] Similarly, budesonide 400 µg once daily did not demonstrate significant cortisol suppression in healthy subjects or patients with asthma. [30,31] In another study, twice-daily budesonide 200 µg (400 µg per day) was shown to significantly suppress urinary cortisol compared with once-daily ciclesonide 320 µg (p<0.05).…”

Ciclesonid - ein neues inhalatives Kortikosteroid

“…Dieses Ergebnis wurde in einer zweiten Studie bestätigt [17]. Eine Vergleichsstudie mit jeweils hochdosierten ICS ergab zwar für Fluticason eine dosisabhängige Suppression der Nebenniererinde, nicht dagegen für Ciclesonid [18]. Hervorzuheben ist, dass Ciclesonid in dieser Untersuchung in der 10−fach höheren Dosis als der Standarddosis eingesetzt wurde.…”

“…In verschiedenen Untersuchungen mit Asthmatikern zeigte sich, dass die einmal tägliche Gabe von Ciclesonid die bronchiale Hy− perreagibilität genauso wirksam unterdrückte wie die zweimal tägliche Gabe von Fluticason [18,25,26]. [29,30].…”