Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis

Ram, Pradeep Kumar; Singh, Shanker K.; Srivastava, Ashish; Kumar, Gagan; Jaiswal, Amit; Yadav, Brijesh; Sk, Garg

doi:10.1007/s12011-020-02263-z

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…IL-10 has protective effects on the intestinal mucosal barrier [29]. Ram et al demonstrated that the intravenous administration of trace element mixtures (Zn concentration at 40 mg) increased serum IL-10 levels in diarrheal calves [30]. Consistent with this report, the serum IL-10 concentration in the current study increased in the ZnO-fed calves at 14 days of age.…”

Section: Discussionsupporting

confidence: 89%

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Liu

Degen

et al. 2023

Animals

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The current study examined the effects of supplementary zinc proteinate (ZnPro) and zinc oxide (ZnO) on growth performance, diarrhea, antioxidant capacity, immune function, and mineral element concentrations of calves aged 1 to 28 days. A total of twenty-four newborn calves were divided randomly into 3 groups (n = 8; 2 males and 6 females per group), and each received: 0 mg/d Zn (CON), 627 mg/d ZnPro (80 mg/d Zn; ZnPro group), and 101 mg/d ZnO (80 mg/d Zn; ZnO group). The calves received the additive in their milk during the first 28 days of life. Compared with the CON group: ZnPro and ZnO improved average daily gain (ADG) and decreased the feed:gain ratio (FGR) between days 1 and 14 (p < 0.05), while the ADG increased and FGR decreased only in the ZnPro group between days 1 and 28 (p < 0.05). The incidence of diarrhea decreased (p < 0.05) in the ZnPro and ZnO groups between days 15 and 28 as well as days 1 and 28, but decreased (p < 0.05) only in the ZnPro group between days 1 and 14. The serum immunoglobulin G (IgG) concentration of the ZnPro and ZnO groups increased on days 14 and 28 (p < 0.05). ZnPro supplementation increased serum IgM concentration during the whole study, while ZnO enhanced serum IgM concentration only on day 14 (p < 0.05). In the ZnO group, the serum concentration of cytokines interleukin (IL)-10 increased on day 14, while that of IL-1β increased on day 28 (p < 0.05). In addition, ZnPro reduced the serum malondialdehyde (MDA) concentration on days 14 and 28 (p < 0.05). Both ZnPro and ZnO increased the serum concentrations of alkaline phosphatase (ALP) and metallothionein (MT) on day 14 (p < 0.05). With zinc supplementation, plasma Zn concentration increased (p < 0.05) on days 14 and 28 of age. We concluded that supplementary ZnPro and ZnO reduced incidences of diarrhea and promoted the immune function, but ZnPro improved the growth performance and antioxidant capacity of Holstein dairy calves to a greater extent.

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Section: Discussionsupporting

confidence: 89%

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Liu

Degen

et al. 2023

Animals

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“…A transmission electron microscopic study, in which the effect of BPQ on oxidative phosphorylation in the mitochondria of E. multilocularis cells was measured in mice, revealed that treatment with BPQ prematurely disrupted parasitic mitochondria (Rufener et al, 2018). In studies to explore the survival pathways of infected cells (Guergnon et al, 2003), parasites exposed to the BPQ terminate their proliferation after the death of macroschizonts and trigger apoptosis of host cells within a few days (Rashid et al, 2019, Ram et al, 2021. A research conducted to compare the intestinal permeability of BPQ used for the treatment of Leishmania donovani infections with other drugs emphasized that the active substance that remained in the tissues for the longest time was BPQ (Venkatesh et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of buparvaquone and paromomycin on oocyst excretion and clinical parameters in diarrheal calves naturally infected with cryptosporidiosis

Evci

Şentürk

2023

J Hellenic Vet Med Soc

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Cryptosporidium is an obligate intracellular parasite that infects a wide variety of hosts. Twenty calves with cryptosporidiosis were divided into two groups. A single dose of 2.5 mg/kg buparvaquone was administered intramuscularly to one group, while 100 mg/kg/day paromomycin was administered orally to the other group. The results obtained from the study in which oocyst shedding and clinical parameters of sucking reflex, mental status, oocyst scattering were observed in both groups offer an effective control option with this study, which provides results that support the application of a single dose of buparvaquone injection against the complex treatment methods applied to calves with cryptosporidiosis in the field. In this study, a significant decrease in oocyst shedding and rapid improvement in clinical findings were observed in calves.

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“…The application of antioxidant complex (Vit-C, Vit-E, silibinin) to reduce nephrotoxicity has been described as a promising study because of the decrease in the parasite load and toxic effect [129] . Ram et al recommend the use of copper, manganese, selenium and zinc injections in new born calves with theileriosis since they help improve immunological ÇENESİZ imbalance [130] . Similarly, it is stated that N-acetyl-L-cystein, which is known to have antioxidant activity, can be used as a drug in the treatment of babesiosis [131] .…”

Section: Antioxidant Use In Parasitic Infestationsmentioning

confidence: 99%

Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

Çenesiz¹

2020

Kafkas Univ Vet Fak Derg

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The formation of reactive oxygen species is a physiological event in aerobic life. In case of infection, if the increased oxidant substances cannot be cleaned sufficiently by antioxidants, oxidative stress occurs. As a result, a number of pathological problems occur by damaging DNA, protein, carbohydrate and lipids. In biological systems, the balance between oxidants and antioxidants is important. In oxidative stress situations where the balance cannot be achieved sufficiently, support can be provided with the use of exogenous antioxidants. However, the molecular structure, route of administration and concentrations of these exogenous antioxidants are important. Otherwise, they may show a pro-oxidative effect. The present rewiev study makes a general overview of oxidative-nitrosative stress markers commonly used in infective clinical studies, antioxidant enzymes and parameters and antioxidant supplements.

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Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis

Cited by 6 publications

References 38 publications

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Comparison of the effects of buparvaquone and paromomycin on oocyst excretion and clinical parameters in diarrheal calves naturally infected with cryptosporidiosis

Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

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