Effects of Insulin treated Established Diabetes Mellitus (EDM) on the Volume of Placental Parenchyma and Weight of the Neonate

Abstract

Taking in mind the effects of diabetes mellitus of varying severity on human placenta and their implication on the well being of the fetus, a quantitative study at the macroscopic level was designed. Sixty post caesarean section human placentas were studied of which thirty were from mothers having insulin treated established diabetes mellitus (EDM) considered as EDM group and thirty were from control mother having no diabetes mellitus. The venous plasma glucose level (fasting and two hours after breakfast) of the diabetic mothers in second and third trimester were recorded and the mean of the values were calculated. The value ranged from 5.93 to 10.10 and the mean was 7.28±0.90. The two groups did not differ significantly from each other with age, weight, height, or parity of the mother or in gestational age. Parenchymal volume in control and EDM group were 300.14±75.43 and 309.25±61.64 respectively. The value showed higher mean value in EDM group. The differences did not reach a significant level. The neonatal weight in control and EDM group were 2.95±0.53 and 3.05±0.52 respectively. The neonate did show a tendency towards being heavier in EDM group, but no reached the significant level. There was a significant positive correlation between the neonatal weight and the parenchymal volume in control and EDM groups. Key words: Established Diabetes Mellitus, Placenta, Parenchyma, Neonates. doi: 10.3329/bja.v7i1.3025 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 45-48

Gross Morphological Study of Gestational Diabetes Mellitus Placenta From South Indian Mothers Compared With Control Placenta

“…The increased placental weight and volume in diabetic mothers were also stated by various authors [14][15][16][17][18][19]. Mayhew et al [20] demonstrated that the placental weight was due to hyperplasia throughout the gestation that was reflected by higher DNA contents and may be endocrine effect of hyperinsulinaemia.…”

Effects of Insulin on Placental, Fetal and Maternal Outcomes in Gestational Diabetes Mellitus

“…The results of both these studies are in favor of our findings. 16 , 17 Placental cord length, membrane completeness, placental shape, consistency, cord insertion, cord color and gross pathologies showed non-significant results between the two groups but with more propensities in the insulin treated group. Verma has discussed that on major gross examination of placentae, there were non-significant differences which is just similar to our results.…”