Effects of intake of <i>Lactobacillus casei</i> subsp. <i>casei</i> 327 on skin conditions: a randomized, double-blind, placebo-controlled, parallel-group study in women

Abstract

Lactic acid bacteria are gut flora that play key roles in intestinal homeostasis, which may affect a variety of physiological functions. Our preliminary double-blind, placebo-controlled, parallel-group trials have suggested that intake of heat-killed Lactobacillus casei subsp. casei 327 (designated L. K-1) is effective for improving skin conditions. The aim of this study was to confirm the effect of L. K-1 intake in a randomized, double-blind, placebo-controlled, parallel-group study in healthy female volunteers. Sixty-four subjects were allocated to either the placebo food group (group P, n=32) or active food group (group A, n=32), in which subjects consumed lactobacillus K-1 50 mg (approximately 1 × 1011 bacteria) daily for 8 weeks. After excluding subjects who declined to participate (n=1), violated restrictions (n=4), or were judged ineligible by the principal investigators (n=1), data obtained with 58 subjects (30 in group A and 28 in group P) were analyzed for efficacy by comparing differences from pretrial levels between the two groups. When the level of transepidermal water loss (TEWL) was measured at the arm, the level of TEWL at week 4 of the intake period was significantly lower in group A than group P (p=0.021), suggesting an improvement of skin barrier function. Analysis of skin condition questionnaire data revealed a significant reduction in skin flakiness on the face (week 4). No adverse events were associated with intake of the test foods. The safety of L. K-1 was also confirmed in an independent open-label trial in 11 healthy subjects who consumed excessive amounts of L. K-1 250 mg (approximately 5 × 1011 bacteria). Intake of L. K-1 may therefore be beneficial to skin condition improvement.

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

“…casei 327 was effective in improving skin conditions that are typical symptoms of food allergies. [ 51 ] Similarly, our results confirm the functional probiotic effects and further underlying mechanism of LcZ in protecting against TM‐induced food allergy.…”

Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

“…casei 327 (L. 327) is another lactic acid bacterium discovered in rice grain. Consumption of heat-killed L. 327 was effective in improving skin conditions of healthy female volunteers [ 9 ].…”

Микробиота Кожи И Возможности Ее Коррекции Пре- И Пробиотиками При Лечении Хронических Дерматозов

“…Все больше данных свидетельствуют о том, что потребление потенциально пробиотиче-ских молочнокислых бактерий может улучшить здоровье кожи [8,[90][91][92][93]. Предполагают, что этому способствует ограничение неблагопри-ятной кишечной бактериальной популяции, производящей фенолы, которые могут нару-шать состояние кожи [8,91].…”

“…Предполагают, что этому способствует ограничение неблагопри-ятной кишечной бактериальной популяции, производящей фенолы, которые могут нару-шать состояние кожи [8,91].…”

“…В ротовой полости содержит-ся 20 % микрофлоры, в гастродуоденальной зоне и дистальных частях пищеварительного тракта -40 %, на коже -18-29 %. Взаимо-действие хозяин-микроорганизм имеет важ-ное значение для разных аспектов нормальной физиологии млекопитающих, в том числе для метаболической активности иммунного гоме-остаза [1, 2, [8][9][10][11][12][13][14][15]. Микробиота управляется специфическими сигналами между микроор-ганизмами, клеточной сигнализацией, мета-болическими взаимодействиями и чувстви-тельностью кворума [1,2,7,16,17].…”