Effects of interaction of tannins with co-existing substances. VII. Inhibitory effects of tannins and related polyphenols on xanthine oxidase.

Hatano, Tsutomu; Yasuhara, Taeko; Yoshihara, Rieko; Agata, Isao; Noro, Tadataka; Okuda, Takuo

doi:10.1248/cpb.38.1224

Cited by 128 publications

(80 citation statements)

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“…The kinetic analyses of VAD presented that the inhibition of XOD occurred in a non-competitive manner. This result was also well in line with the result of the study conducted by Hatano et al [40], which presented the non-competitive inhibition of XOD with VAD from Mallotus japonicus [12]. The main purpose of the present study was to determine the inhibitory effect of CYN on XOD activity since it is a target enzyme for the treatment of gout and related symptoms.…”

Section: Discussionsupporting

confidence: 91%

Inhibition of xanthine oxidase by Caulerpenyne from Caulerpa prolifera

Cengiz¹,

Çavaş²,

Yurdakoç³

et al. 2012

Turk J Bioch

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Section: Discussionsupporting

confidence: 91%

Inhibition of xanthine oxidase by Caulerpenyne from Caulerpa prolifera

Cengiz¹,

Çavaş²,

Yurdakoç³

et al. 2012

Turk J Bioch

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“…Most importantly, tannin compounds are present in this plant, including hydrolysable gallotannins (11)(12)(13)(14)(15), whose primary structural unit is poly(d-glucose carbonate). In general, the presence of antioxidant elements in the structure of sumac and their half maximal inhibitory concentration index is very important in this plant (16)(17)(18)(19). To a large extent, it is because of this that antioxidant expectations are justified from experiments on this plant.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sumac (Rhus coriaria) Extract on Blood Lipid Profile in White Wistar Rat

Soltani

Vahidi

Dehghan-Tezerjani

et al. 2017

IMMINV

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Background: Hyperlipidemia is a chronic disease whose current treatments are proper diet and chemical drugs. The evaluation of accessible medicinal plants has an important role in the prevention and treatment of hyperlipidemia. In this study, we investigated the effect of sumac (Rhus coriaria) extract on blood lipid profile in white Wistar rats. Methods: This laboratory animal experiment was conducted over 4 weeks on 21 white Wistar rats. The rats were divided into three groups and were fed by normal diet, fatty diet without sumac extract, and fatty diet with sumac extract. Rats were excluded if they exhibited sick-like behaviors. Data were analyzed in SPSS v. 16 software using analysis of variance and least significant difference tests. Results: The mean weight of the rats was 310±26 g. From the second week to the end of the study, the mean blood cholesterol was significantly different in the rats that received a fatty diet with sumac compared to the rats in the control group (P=0.001). Also during the study, mean triglyceride levels were significantly higher in the rats that received a fatty diet with sumac compared to the rats in the control group (P=0.047). During the study, too, mean high-density lipoprotein and low-density lipoprotein levels showed no significant change (P=0.641). Conclusion: We found that, in a small sample of white Wistar rats, sumac with a fatty diet effectively reduced blood cholesterol and may possibly assist in the prevention and treatment of hyperlipidemia.

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“…The phenolic compounds are very important plant constituents because of their scavenging ability due to their hydroxyl groups [ 21 ]. Based on the absorbance values of the essential oil and various extract solutions, reacted with Folin-Ciocalteu reagent and compared with the standard solutions of gallic acid equivalents, as described above, total phenolics are shown in Figure 4.…”

Section: Resultsmentioning

confidence: 99%