Effects of intermittent administration of pamidronate on the mechanical properties of canine cortical and trabecular bone

Acito, A.; Kasra, M.; Lee, J. M.; Grynpas, Marc D.

doi:10.1002/jor.1100120518

Cited by 14 publications

(6 citation statements)

References 16 publications

(14 reference statements)

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“…Kang et al [22] reported elastic moduli of trabecular specimens from canine femoral heads of 428 ± 237 MPa which is also much lower than what we observed in our study; their results were obtained by conventional compression testing. Several other studies have been carried out investigating elastic moduli of canine trabecular bone specimens[14,16,19]. Those results are not comparable with our data because the authors measured elastic moduli of whole specimens rather than Young's moduli on the tissue level.…”

Section: Discussioncontrasting

confidence: 95%

Mechanical properties of femoral trabecular bone in dogs

Pressel

Bouguecha²,

Vogt

et al. 2005

BioMed Eng OnLine

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Background: Studying mechanical properties of canine trabecular bone is important for a better understanding of fracture mechanics or bone disorders and is also needed for numerical simulation of canine femora. No detailed data about elastic moduli and degrees of anisotropy of canine femoral trabecular bone has been published so far, hence the purpose of this study was to measure the elastic modulus of trabecular bone in canine femoral heads by ultrasound testing and to assess whether assuming isotropy of the cancellous bone in femoral heads in dogs is a valid simplification.

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Section: Discussioncontrasting

confidence: 95%

Mechanical properties of femoral trabecular bone in dogs

Pressel

Bouguecha²,

Vogt

et al. 2005

BioMed Eng OnLine

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“…Although a number of studies have looked at the effects of bisphosphonates on trabecular bone biomechanics in large animals [50][51][52][53][54][55][56][57], we could find only two that looked specifically for differences in mechanical properties relative to density [49,58]. Neither of the studies observed significant changes in the relationships as a result of treatment.…”

Section: What Do We Know About Trabecular Bone Quality?mentioning

confidence: 83%

A biomechanical perspective on bone quality

Hernandez¹,

Keaveny²

2006

Bone

273

183

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Observations that dual-energy x-ray absorptiometry (DXA) measures of areal bone mineral density cannot completely explain fracture incidence after anti-resorptive treatment have led to renewed interest in bone quality. Bone quality is a vague term, but generally refers to the effects of skeletal factors that contribute to bone strength but are not accounted for by measures of bone mass. Since a clinical fracture is ultimately a mechanical event, it follows then that any clinically relevant modification of bone quality must change bone biomechanical performance relative to bone mass. In this perspective, we discuss a framework for assessing the clinically relevant effects of bone quality based on two general concepts: 1) the biomechanical effects of bone quality can be quantified from analysis of the relationship between bone mechanical performance and bone density; and 2) because of its hierarchical nature, biomechanical testing of bone at different physical scales (<1mm, 1mm, 1 cm, etc.) can be used to isolate the scale at which the most clinically relevant changes in bone quality occur. As an example, we review data regarding the relationship between the strength and density in excised specimens of trabecular bone and highlight the fact that it is not yet clear how this relationship changes during aging, osteoporosis development, and anti-resorptive treatment. Further study of new and existing data using this framework should provide insight into the role of bone quality in osteoporotic fracture risk.

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“…Our study model of young healthy adult dogs with joint replacements most closely parallels that of Acito et al, 20 who used a healthy male canine model, but evaluated the effects of an earlier bisphosphonate formulation (pamidronate). Similar to our study, they observed no statistically significant differences in whole bone properties.…”

Section: Discussionmentioning

confidence: 99%

“…Some discretion must be used in comparing our study with previous animal research on alendronate, and other bisphosphonates in general, due to the wide variety of animal models, specific bisphosphonates, treatment protocols, and evaluation time points. Several studies in animals have been performed evaluating the mechanical properties of bone after alendronate and other bisphosphonate therapy 17–21. Most, although not all, have shown increases in the mechanical properties of bone following treatment; however, the results have been inconsistent across various bone tissue types and sample locations.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in animals have been performed evaluating the mechanical properties of bone after alendronate and other bisphosphonate therapy. [17][18][19][20][21] Most, although not all, have shown increases in the mechanical properties of bone following treatment; however, the results have been inconsistent across various bone tissue types and sample locations.…”

Section: Discussionmentioning

confidence: 99%

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Mechanical evaluation of bone samples following alendronate therapy in healthy male dogs

Fischer¹,

Vikoren²,

Ney³

et al. 2005

J Biomed Mater Res

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Alendronate and other bisphosphonates are clinically efficacious in treating postmenopausal osteoporosis, Paget's disease and hypercalcemia associated with malignancy. Because bisphosphonates are being considered for use in younger patients with joint replacements to prevent osteolysis, and for stress fracture prophylaxis in military recruits, it is important to know how bisphosphonate therapy affects healthy bone. We sought to determine whether bones from healthy male dogs exhibit alterations in structural or mechanical properties following alendronate treatment for 23 weeks. We tested trabecular tissue samples in compression and determined tissue ash density. We tested whole long bones in bending and torsion. For trabecular samples, we evaluated trabecular modulus, strength, and density. For whole bone specimens, we compared structural stiffness and ultimate load. We found no significant differences in any measure, between canines treated with alendronate for 23 weeks and controls, although we found consistent trends toward higher properties in the treated group. Correlation analysis revealed significant relationships between stiffness and strength measures for each mechanical test. Our results indicate bisphosphonate treatment in healthy canines does not weaken the properties of bone. The trends indicate a slight positive overall effect of alendronate treatment on the mechanical properties of healthy canine bone.

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Effects of intermittent administration of pamidronate on the mechanical properties of canine cortical and trabecular bone

Cited by 14 publications

References 16 publications

Mechanical properties of femoral trabecular bone in dogs

Mechanical properties of femoral trabecular bone in dogs

A biomechanical perspective on bone quality

Mechanical evaluation of bone samples following alendronate therapy in healthy male dogs

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