Effects of Intermittent Theta Burst Stimulation on Manual Dexterity and Motor Imagery in Patients with Multiple Sclerosis: A Quasi-Experimental Controlled Study

Azin, Mahdieh; Zangiabadi, Nasser; Iranmanesh, Farhad; Baneshi, Mohammad Reza; Banihashem, Seyedshahab

doi:10.5812/ircmj.27056

Cited by 22 publications

(35 citation statements)

References 34 publications

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“…As a type of transcranial magnetic stimulation, repetitive transcranial magnetic stimulation (rTMS) plays a potential role in the treatment of MS, especially in improving fatigue and spasticity in patients with MS (Liu et al, 2019;Korzhova et al, 2018;Boutière et al, 2017;Korzhova et al, 2016;Abdelkader et al, 2013;Schippling et al, 2014). However, several recent studies contradicted the findings of previous studies (Dieguez-Varela et al, 2019;Gaede et al, 2018;Azin et al, 2016). Therefore, the purpose of this article was to conduct a systematic review and meta-analysis of all available publications to evaluate the intervention effects of rTMS in patients with MS.…”

Section: Introductionmentioning

confidence: 90%

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Chen

Yin

et al. 2022

Multiple Sclerosis and Related Disorders

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This study aims to quantitatively evaluate and summarize the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with multiple sclerosis (MS). Methods: The PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, CBM, CNKI and Wanfang databases were searched for randomized controlled trails (RCTs) from their inception through July 10, 2021. RCTs that met the inclusion and exclusion criteria were included in the study, and RevMan software was used for meta-analysis. Outcome indicators included scores on the fatigue severity scale (FSS), modified Ashworth scale (MAS) and the H/M amplitude ratio of the Soleus H reflex. When p < 0.05, the difference was considered significant. Results: A total of 10 articles were included in this study, with 8 of them in the quantitative synthesis. The metaanalysis showed that the short-term effect of rTMS treatment for the MAS was better than that of the control treatment (95% CI: − 1.27 to − 0.25, p = 0.004); and compared with the control group, the effect of rTMS treatment for the H/M ratio showed a significant effect (95% CI: − 0.12 to − 0.03, p = 0.002); while the treatment effect for the FSS was not significant (95% CI: − 4.87 to 1.28, p = 0.25). Conclusion: Our results provide preliminary evidence for the treatment of patients with MS by rTMS, especially for improving spasticity, but further research is needed to evaluate its effects on fatigue.

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Section: Introductionmentioning

confidence: 90%

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Chen

Yin

et al. 2022

Multiple Sclerosis and Related Disorders

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“…24 Also, 10 daily sessions of iTBS over the hand M1 were associated with significantly better improvement of manual dexterity compared with sham stimulation. 25 Anodal tDCS applied to M1 contralateral to the more severely impaired hand increased the corticospinal output and projection strength evaluated with the input/output curve, but no behavioral effects were measured. 26…”

Section: Pyramidal Functionmentioning

confidence: 98%

Beyond rehabilitation in MS: Insights from non-invasive brain stimulation

et al. 2019

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The neurobiological basis for targeting neuronal activity in MS brainTo appreciate the relevance of central stimulationbased interventions in MS treatment, we need to start from two basic principles of the neurobiology. First, synapses are highly plastic structures that easily respond and adapt to environmental stimulations, by fine-tuning their connectivity to their synaptic partners. Moreover, neurons can make synaptic contacts with other neurons that have lost part of their synapses in order to restore appropriate functioning of the circuitry and to avoid neuronal loss, thus playing a neuroprotective role. 2 Second, myelin formation and maintenance in the adult brain is a highly dynamic and complex process that continuously takes place to ensure the proper sheathing of axons and, more importantly, is tightly regulated by neuronal activity. 3 These simple neurobiological concepts of neuronal and myelin plasticity lay the ground for developing treatments for a neurological disorder like MS, where an early and progressive loss of synapses occurs in concomitance with demyelination. Therefore, neurons can be targeted to modulate neuronal circuitry and to promote remyelination, which, in fact, is a therapeutic strategy currently under investigation for MS treatment.The idea that neuronal activity can be modulated to modify the disease course and to mitigate the Abstract: Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful approach targeting central nervous system plasticity. Another driver of brain plasticity is non-invasive brain stimulation (NIBS), receiving recent attention in neurology, particularly for its potential synergy with neurorehabilitation and as add-on treatment for several neurological conditions, from pain to fatigue to sensorimotor and cognitive deficits. In this review, we will resume the evidence exploring the neurobiological basis of NIBS and its applications to MS-related conditions.

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“…Similar to this case report, Azin's group observed an improvement in patients' manual dexterity after treatment. They studied the ‘Nine-Hole Peg Test,’ but the rest of the psychological items that we present are novel ( 16 ). There are also no studies in the literature that have checked the biochemical profile about oxidative damage in MS patients after being treated with TMS.…”

Section: Discussionmentioning

confidence: 99%

“…Three years ago, given her disability and lack of response to the symptomatic treatment prescribed, rTMS treatment was proposed, which she accepted. Based on the results obtained with TMS in previous clinical studies carried out in patients with MS, as well as in its equivalent experimental model in rats (experimental autoimmune encephalomyelitis, EAE) and in other neurodegenerative diseases, the main objective was to improve the degree of disability in this patient ( 6 , 9 – 16 ). We also wanted to examine her evolution at the neuropsychological level and her biomarkers of oxidative damage in blood, in order to look for links between these aspects ( 17 – 19 ).…”

Section: Case Presentationmentioning

confidence: 99%

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

et al. 2020

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Multiple sclerosis (MS) is a neurodegenerative condition whose manifestation and clinical evolution can present themselves in very different ways. Analogously, its treatment has to be personalized and the patient's response may be idiosyncratic. At this moment there is no cure for it, in addition to its clinical course sometimes being torpid, with a poor response to any treatment. However, Transcranial Magnetic Stimulation (TMS) has demonstrated its usefulness as a non-invasive therapeutic tool for the treatment of some psychiatric and neurodegenerative diseases. Some studies show that the application of rTMS implies improvement in patients with MS at various levels, but the effects at the psychometric level and the redox profile in blood have never been studied before, despite the fact that both aspects have been related to the severity of MS and its evolution. Here we present the case of a woman diagnosed with relapsing-remitting multiple sclerosis (RRMS) at the age of 33, with a rapid progression of her illness and a poor response to different treatments previously prescribed for 9 years. In view of the patient's clinical course, a compassionate treatment with rTMS for 1 year was proposed. Starting from the fourth month of treatment, when reviewing the status of her disease, the patient denoted a clear improvement at different levels. There followed out psychometric evaluations and blood analyses, that showed both an improvement in her neuropsychological functions and a reduction in oxidative stress in plasma, in correspondence with therTMS treatment.

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Effects of Intermittent Theta Burst Stimulation on Manual Dexterity and Motor Imagery in Patients with Multiple Sclerosis: A Quasi-Experimental Controlled Study

Cited by 22 publications

References 34 publications

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Beyond rehabilitation in MS: Insights from non-invasive brain stimulation

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

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