Effects of internal pressure and surface tension on the growth-induced wrinkling of mucosae

Xie, Wei-Hua; Li, Bo; Cao, Yanping; Feng, Xi‐Qiao

doi:10.1016/j.jmbbm.2013.05.009

Cited by 23 publications

(18 citation statements)

References 32 publications

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“…Specifically, the stress in the submucosal–mucosal layer was found to be higher than in the muscle layer owing to the differences in structure and material properties in these two layers. Furthermore, the patterns of mucosal folds are dictated by the thickness and the mechanical properties of the esophageal mucosal and submucosal layers . A recent anatomy‐based lower esophageal sphincter (LES) model showed that the intraluminal pressure values predicted by the 3D model are mainly due to the contraction of the circular muscle layer, consistent with the predictions of experimental data found in the literature …”

Section: Computer Modeling Of Esophageal Functionsupporting

confidence: 83%

“…Furthermore, the patterns of mucosal folds are dictated by the thickness and the mechanical properties of the esophageal mucosal and submucosal layers. [92][93][94] A recent anatomy-based lower esophageal sphincter (LES) model 11,12 showed that the intraluminal pressure values predicted by the 3D model are mainly due to the contraction of the circular muscle layer, consistent with the predictions of experimental data found in the literature. 18,31,95 Coupling with fluid stresses (pressure and shear stress) at the fluid-muscle interface Esophageal peristaltic transport is an inherently mechanical phenomenon coordinated by the central and enteric nervous systems; the transport of bolus requires mechanical activities from interrelationships between muscle contraction and intrabolus force.…”

Section: Computer Modeling Of Esophageal Functionsupporting

confidence: 74%

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The Esophagiome: concept, status, and future perspectives

Gregersen

Liao

Brasseur

2016

Annals of the New York Academy of Sciences

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The term "Esophagiome" is meant to imply a holistic, multiscale treatment of esophageal function from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents. The development and application of multiscale mathematical models of esophageal function are central to the Esophagiome concept. These model elements underlie the development of a "virtual esophagus" modeling framework to characterize and analyze function and disease by quantitatively contrasting normal and pathophysiological function. Functional models incorporate anatomical details with sensory-motor properties and functional responses, especially related to biomechanical functions, such as bolus transport and gastrointestinal fluid mixing. This brief review provides insight into Esophagiome research. Future advanced models can provide predictive evaluations of the therapeutic consequences of surgical and endoscopic treatments and will aim to facilitate clinical diagnostics and treatment.

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Section: Computer Modeling Of Esophageal Functionsupporting

confidence: 83%

Section: Computer Modeling Of Esophageal Functionsupporting

confidence: 74%

The Esophagiome: concept, status, and future perspectives

Gregersen

Liao

Brasseur

2016

Annals of the New York Academy of Sciences

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“…For conceptual simplicity, we have initiated these alterations exclusively through the growth of the mucosal layer, while in reality, airway wall remodeling is a multifactorial process. In future studies, we will include the effects of the thickening of the smooth muscle layer [13,32] and of gradual alterations in composition across all three layers [3]. A more realistic model might also require us to incorporate the effects of anisotropic elasticity and anisotropic growth [41,48], for example, through an independent representation of surface growth [43,49] and thickness growth [40,44].…”

Section: Discussionmentioning

confidence: 99%

On the Role of Mechanics in Chronic Lung Disease

2013

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Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen. The critical failure conditions for airway folding have been studied intensely for idealized circular cross-sections. However, the role of airway branching during this process is unknown. Here, we show that the geometry of the bronchial tree plays a crucial role in chronic airway obstruction and that critical failure conditions vary significantly along a branching airway segment. We perform systematic parametric studies for varying airway cross-sections using a computational model for mucosal thickening based on the theory of finite growth. Our simulations indicate that smaller airways are at a higher risk of narrowing than larger airways and that regions away from a branch narrow more drastically than regions close to a branch. These results agree with clinical observations and could help explain the underlying mechanisms of progressive airway obstruction. Understanding growth-induced instabilities in constrained geometries has immediate biomedical applications beyond asthma and chronic bronchitis in the diagnostics and treatment of chronic gastritis, obstructive sleep apnea and breast cancer.

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“…The fluid mechanics of the lung have been extensively studied using both idealized and patient-specific models [32,59]. However, existing solid mechanics studies which focus on three-dimensional biological geometries are few [54,63], mainly analytical [7,17], fail to predict emerging surface morphologies beyond the onset of folding [60,73], and typically neglect the characteristic branching of the lung [8, 27, 38]. Here we address these limitations by extending airway remodeling mechanics to realistic patient-specific airway branch models created from magnetic resonance images.…”

Section: Introductionmentioning

confidence: 99%

Patient-Specific Airway Wall Remodeling in Chronic Lung Disease

2015

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Chronic lung disease affects more than a quarter of the adult population; yet, the mechanics of the airways are poorly understood. The pathophysiology of chronic lung disease is commonly characterized by mucosal growth and smooth muscle contraction of the airways, which initiate an inward folding of the mucosal layer and progressive airflow obstruction. Since the degree of obstruction is closely correlated with the number of folds, mucosal folding has been extensively studied in idealized circular cross sections. However, airflow obstruction has never been studied in real airway geometries; the behavior of imperfect, non-cylindrical, continuously branching airways remains unknown. Here we model the effects of chronic lung disease using the nonlinear field theories of mechanics supplemented by the theory of finite growth. We perform finite element analysis of patient-specific Y-branch segments created from magnetic resonance images. We demonstrate that the mucosal folding pattern is insensitive to the specific airway geometry, but that it critically depends on the mucosal and submucosal stiffness, thickness, and loading mechanism. Our results suggests that patient-specific airway models with inherent geometric imperfections are more sensitive to obstruction than idealized circular models. Our models help to explain the pathophysiology of airway obstruction in chronic lung disease and hold promise to improve the diagnostics and treatment of asthma, bronchitis, chronic obstructive pulmonary disease, and respiratory failure.

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Effects of internal pressure and surface tension on the growth-induced wrinkling of mucosae

Cited by 23 publications

References 32 publications

The Esophagiome: concept, status, and future perspectives

The Esophagiome: concept, status, and future perspectives

On the Role of Mechanics in Chronic Lung Disease

Patient-Specific Airway Wall Remodeling in Chronic Lung Disease

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