Background:
Extended application of intracanal medicaments such as calcium hydroxide (CH) and triple antibiotic paste (TAP) is documented to reduce dentin’s resistance to fracture.
Aim:
This study intended to evaluate the resistance to fracture of root dentin treated with different medicaments – CH, TAP, CH with chlorhexidine (CHX) and lycopene (LP), and chitosan acetate (CA) – over 7, 14, and 42 days.
Materials and Methods:
Seventy-five single-rooted human mandibular premolars were biomechanically prepared and categorized into five groups based on the medicament used, with further subdivision based on application duration. Fracture resistance was tested after each time interval.
Statistical Analysis:
Within-group comparisons were analyzed using repeated measures analysis of variance (ANOVA), while inter-group comparisons used a one-way ANOVA test at a 5% significance level.
Results:
At 7 days, no statistically notable differences were found among the groups. However, by day 14 and day 42, the groups treated with CH and TAP exhibited significantly reduced fracture resistance compared to the other groups.
Conclusion:
Combining LP with CH and CHX, or using CA, did not reduce radicular dentin fracture resistance, unlike TAP and CH. These findings suggest LP and CA as viable alternatives, potentially minimizing the adverse effects of traditional treatments.