Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents

Horii, Yuko; Nakakita, Yasukazu; Fujisaki, Yoshiyuki; Yamamoto, Saori; Itoh, Nanako; Miyazaki, Kuniyuki; Kaneda, Hirotaka; Oishi, Katsutaka; Shigyo, Tatsuro; Nonomura, Katsuya

doi:10.1016/j.neulet.2013.01.037

Cited by 28 publications

(15 citation statements)

References 5 publications

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“…The mechanism underlying this effect is suggested to be the following: i) L. brevis SBC8803 stimulates serotonin release from intestinal cells such as enterochromaffin cells (18); ii) the resulting serotonin elevates afferent intestinal vagal nerve activity (19), which in turn iii) enhances efferent gastric vagal nerve activity (19) and iv) cutaneous arterial sympathetic nerve activity (15). Therefore, in addition to the habitual consumption of lactic fermentation foods, the use of cutaneous blood flow as a marker for normalization of subject populations may help design future studies that test skin moisturization conditions.…”

Section: Discussionmentioning

confidence: 99%

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Ogawa

Saiki

Matsui

et al. 2016

Experimental and Therapeutic Medicine

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Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and intestinal tumor growth amongst others. Our previous investigations have suggested that oral intake of heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88™) suppresses dermatitis by modulating the immune function in an atopic dermatitis mouse model. The aim of the present study was to investigate the effect of heat-killed L. brevis SBC8803 intake on skin hydration conditions in humans. A randomized, double-blind, placebo-controlled study was conducted with volunteers with slightly higher levels of transepidermal water loss (TEWL) on the forearm. The subjects (126 people aged between 21 and 59 years) were randomly allocated to three groups so that the level of TEWL and the age were distributed equally among the groups. The subjects took placebo or heat-killed L. brevis SBC8803 at a daily dose of 25 or 50 mg for 12 weeks. Following the exclusion of eight subjects for plausible reasons (two withdrawals from the study, two for study violations, one for not meeting exclusion criteria and three due to their physical condition), 118 subjects were subjected to the analysis. The results of the present study revealed that following the analysis of the whole populations, marginal differences were observed in TEWL (for example, suppression of skin water loss) at the neck in the 25 mg/day group at week 8 and at the lower eye region in the 50 mg/day group at week 4 (P=0.05 and 0.09, respectively, compared with the placebo group analyzed by Dunnett's test). A significant increase in corneal hydration was also observed at the neck in the 25 mg/day group at week 12 (P=0.06, as compared with the placebo group as analyzed by Dunnett's test). In the analysis of the subpopulations whose habitual frequency of taking lactic fermentation products was less than once per week, the levels of corneal hydration at the neck (in the 50 mg/day group) and lower eye region (in the 25 mg/day group) were significantly increased at week 12 (P<0.05). In conclusion, the results of the present investigation suggest that oral intake of heat-killed L. brevis SBC8803 is effective at improving skin hydration conditions in populations with low habitual frequency of taking lactic fermentation products.

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Section: Discussionmentioning

confidence: 99%

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Ogawa

Saiki

Matsui

et al. 2016

Experimental and Therapeutic Medicine

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“…We examined the effects of heat-killed Lactobacillus brevis SBC8803 [6][7][8] on autonomic neurotransmissions and found that changes induced in autonomic neuro-transmissions by this heat-killed strain may be mediated by serotonin 3 (5-HT3) receptors [9]. On the basis of these results, it was suggested that intestinally injected L. brevis SBC8803 stimulates afferent intestinal vagal nerve activity (IVNA) through 5-HT3 receptors; this information is then transmitted to the CNS, which in turn increases efferent gastric vagal nerve activity (GVNA), and GVNA stimulation enhances appetite [9]. To the best of our knowledge, this is the first report that 5-HT3 receptors may be involved in the interactions between LABs and autonomic nerves.…”

Section: Introductionmentioning

confidence: 99%

Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Induces Serotonin Release from Intestinal Cells

Nakaita¹,

Kaneda²,

Shigyo³

2013

FNS

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Previously, we reported that changes induced in autonomic neurotransmission in rats by Lactobacillus brevis SBC8803 may be mediated by serotonin 3 (5-HT3) receptors. In this study, we evaluated the effects of heat-killed L. brevis SBC8803 on serotonin (5-HT) releasing from intestinal cells. In the in vitro study, L. brevis SBC8803 stimulated 5-HT release from cultured rat endocrine RIN-14B cells (SBC8803 vs. sterile water; P < 0.01). For in vivo study, 2 mg of heat-killed L. brevis SBC8803 was administered using a stomach sonde (feeding needle) to C57BL/6J mice. Analysis of plasma by ELISA showed gradually increase in 5-HT concentrations (0 min vs. 60 min; P < 0.05). ELISA of ex vivo cultured intestinal loops composed of duodenum and part of the jejunum, from C3H/HeN and C57BL/6J male mice indicated that L. brevis SBC8803 effectively induced 5-HT release (SBC8803 vs. sterile water; P < 0.01). These experimental results suggest that heat-killed L. brevis SBC8803 may stimulate 5-HT release from mouse intestinal cells such as enterochromaffin cells.

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“…Moreover, these behavioral effects are absent in vagotomized mice, suggesting that the vagus is a major modulatory constitutive communication pathway between the brain and bacteria in the gut. As noted above, SBC8803 activates both efferent GVNA and afferent IVNA (23), suggesting that SBC8803 improves CSD by modulating the central expression of GABA receptors. We previously assessed the effects of SBC8803 consumption in a non-randomized, placebo-controlled, double-blind, crossover pilot study of volunteers with sleep challenges (such as poor-quality sleep, waking during sleep) (11).…”

Section: Discussionmentioning

confidence: 69%

“…These findings suggest that the activation of gastrointestinal 5-HT3 receptors plays important roles in protecting organisms against various stressors. We previously showed that the intraduodenal administration of heat-killed SBC8803 elevates both efferent gastric (efferent GVNA) and afferent intestinal (afferent IVNA) vagal nerve activity in rats (23). Increases in both of efferent GVNA and afferent IVNA due to SBC8803 are abolished by intravenously administered 5-HT3 receptor antagonist (24).…”

Section: Discussionmentioning

confidence: 98%

Dietary Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

Higo-Yamamoto

Yamamoto

Miyazaki

et al. 2019

J Nutr Sci Vitaminol

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We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep in mice and humans. The present study examined whether SBC8803 improves psychophysiological stress-induced chronic sleep disorders (CSD) using a mouse model characterized by disrupted circadian rhythms of wheel-running activity and sleep-wake cycles. Mice were fed with a diet supplemented with 0.5% heat-killed SBC8803 for 6 wk and imposed stress-induced CSD for last 2 wk. Dietary SBC8803 suppressed the reduction in wheel-running activity induced by CSD. Electroencephalography (EEG) revealed that SBC8803 significantly restored wakefulness and increased non-rapid eye movement (NREM) sleep during the second half of the active phase during CSD. The CSD-induced reduction in EEG slow wave activity, a marker of NREM sleep intensity, during the beginning of the inactive phase was significantly improved by SBC8803 supplementation. These findings suggest that dietary heat-killed SBC8803 confers beneficial effects on insomnia and circadian sleep disorders induced by psychophysiological stress.

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Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents

Cited by 28 publications

References 5 publications

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Induces Serotonin Release from Intestinal Cells

Dietary Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

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Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents

Cited by 28 publications

References 5 publications

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

Heat-Killed &lt;i&gt;Lactobacillus brevis&lt;/i&gt; SBC8803 Induces Serotonin Release from Intestinal Cells

Dietary Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

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Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Induces Serotonin Release from Intestinal Cells