Effects of Intraluminal Epidermal Growth Factor on Mucosal Proliferation in the Small Intestine of Adult Rats

Effects of Nursing on Growth and Development of Small Bowel Mucosa in Newborn Piglets

“…ODC is an enzyme that contributes to the process of DNA synthesis; increased activity often serves as marker of stimulation of cell proliferation (8,30). A transient rise in mucosal ODC activity is seen early in neonatal maturation of the small bowel in rodents and is similar to the transient rise occurring during the initiation of adaptive growth of small intestine in adult animals (30,36).…”

Oral Transforming Growth Factor-α Enhances Jejunal Mucosal Recovery and Electrical Resistance in Piglet Rotavirus Enteritis

“…EGF and TGFa are trophic peptides in saliva, human milk, and intestinal epithelium (21). In vivo studies, in which EGF was given to animals orally or systemically, have generally shown stirnulatory effects of exogenous EGF on the intestine (7,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Parenteral EGF has consistently been shown to enhance intestinal proliferation and in some cases to alter the expression of brush border enzymes.…”

“…Breast-fed infants in developing countries have less severe diarrhea and decreased diarrheal mortality compared with formula-fed infants (5). EGF, a well characterized peptide, is abundant in human milk, duodenal secretions, and saliva and is known to stimulate proliferation of gastrointestinal epithelial cells (6, 7). TGFa is 174 RHOADS…”

New growth factor therapies aimed at improving intestinal adaptation in short bowel syndrome

“…74 Epidermal growth factor stimulates messenger RNA, DNA, and protein synthesis in many cell types, 75 and has been shown to increase villus height, protein content, and the uptake of glucose and electrolytes in the intestine. 44,[76][77][78] Lessons from animal models Administration of EGF has been shown to enhance intestinal adaptation and preserve bowel morphology and function following massive small bowel resection by stimulating the proliferation of both enterocytes and myocytes (Table 3. 77,79 In mice devoid of EGF or exhibiting a disrupted EGF receptor (EGFR), intestinal adaptation is markedly inhibited, and the characteristic adaptationinduced increase in villus height, crypt depth, ileal DNA and protein content is attenuated in these mice following 50% small bowel resection. 81,82 Following systemic and oral administration of recombinant EGF (rEGF) to EGF-deficient mice, structural adaptation was comparable to wild-type mice.…”