2010
DOI: 10.2460/ajvr.71.3.342
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Effects of intravenous administration of lipopolysaccharide on cytochrome P450 isoforms and hepatic drug metabolizing enzymes in swine

Abstract: Effect of LPS treatment on swine CYPs appeared to be isoform specific; age-related metabolic status of the swine and the LPS dose modified this effect. Lipopolysaccharide-induced inflammation may affect metabolism of drugs and xenobiotics in swine.

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Cited by 7 publications
(1 citation statement)
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“…LPS can alter drug metabolism pathways through cytochrome P 450 inhibition and consequently could alter the relationship between parent and metabolite. Flunixin and 5-hydroxy flunixin concentration ratios within the individual animals were found to be relatively constant (∼2-fold variation) among all collection time points in urine (data not shown), remarkable because of the independence of the various processes involved.…”
Section: Resultsmentioning
confidence: 99%
“…LPS can alter drug metabolism pathways through cytochrome P 450 inhibition and consequently could alter the relationship between parent and metabolite. Flunixin and 5-hydroxy flunixin concentration ratios within the individual animals were found to be relatively constant (∼2-fold variation) among all collection time points in urine (data not shown), remarkable because of the independence of the various processes involved.…”
Section: Resultsmentioning
confidence: 99%