Effects of Intravenous Infusion of Dopamine in Cirrhotics

Espiritu, Carmelita R.; Mendoza, Jose; Yeh, Billy K.

doi:10.3181/00379727-141-36770

Experimental Biology and Medicine

1972

DOI: 10.3181/00379727-141-36770

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Effects of Intravenous Infusion of Dopamine in Cirrhotics

Carmelita R. Espiritu¹,

Jose Mendoza²,

Billy K. Yeh³

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1973

1998

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Cited by 5 publications

(2 citation statements)

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“…Intravenous infusion of low‐dose dopamine at a rate of 2 μg/kg/min may have dopaminergic effects manifesting as decreased renal vascular resistance and causing renal vasodilatation, increased renal blood How and improved glomerular filtration rate (GFR), but without significant changes in systemic haemodynamics 1–6 …”

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confidence: 99%

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Low‐dose Dopamine Infusion in Cirrhosis With Refractory Ascites

Lin

Lee

Kao

1998

Int J Clinical Practice

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SUMMARY To investigate the effect of dopamine on the renal blood flow, five cirrhotic patients with refractory ascites but no hepatorenal syndrome were allocated to this study. Low‐dose dopamine infusion at a rate of 2 μg/kg/min was undertaken at least for 24 hours. Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were measured by computerised nuclear scanning before and after dopamine infusion. The results revealed no difference in the changes of blood urea nitrogen, creatinine, creatinine clearance, blood pressure, pulse rate, serum sodium, serum aldosterone and GFR despite insignificant increases in urine output and urinary sodium excretion after dopamine infusion. However, ERBF values before and after dopamine infusion were 288‐311, 208‐267, 418‐442, 246‐270 and 262‐396 ml/min in these five patients respectively and showed significant increase (p <0.01). Our study revealed that low‐dose dopamine infusion could increase ERPF in cirrhotic patients with refractory ascites.

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confidence: 99%

“…These clinical applications have been carried out by only a few investigators 2 , 3 , 13 , 14 . Moore et al 15 reported that approximately 5% of patients with HRS responded dramatically to dopamine infusion.…”

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confidence: 99%

Low‐dose Dopamine Infusion in Cirrhosis With Refractory Ascites

Lin

Lee

Kao

1998

Int J Clinical Practice

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Response to Dopamine Hydrochloride in the Hepatorenal Syndrome

et al. 1975

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Systemic, splanchnic and renal hemodynamic effects of a dopaminergic dose of dopamine in patients with cirrhosis

et al. 1991

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The effects of dopamine on kidney function have not been elucidated in patients with cirrhosis. Moreover, although increased portal pressure has been observed with supradopaminergic doses of dopamine in these patients, the splanchnic hemodynamic effects of low doses of dopamine have not been previously studied. Thus we studied the acute systemic, splanchnic and renal hemodynamic effects of a dopaminergic dose of dopamine (1.5 micrograms/kg body wt min) in nine cirrhotic patients. Plasma dopamine levels increased markedly from 35 +/- 20 pg/ml to 31,400 +/- 4,900 pg/ml during dopamine administration. A significant diastolic pressure decrease of 10% was associated with a 15% increase in heart rate. Cardiac output was not altered. Although dopamine significantly increased azygos blood flow by 16%, wedged and free hepatic venous pressures were not altered. Dopamine significantly increased renal blood flow by 31%, but did not change the glomerular filtration rate. We conclude that a dopaminergic dose of dopamine increases azygos blood flow but not the hepatic venous pressure gradient. Finally, although it increases renal blood flow, dopamine does not seem to have any beneficial effects on glomerular filtration rate in cirrhotic patients.

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Effects of Intravenous Infusion of Dopamine in Cirrhotics

Cited by 5 publications

References 3 publications

Low‐dose Dopamine Infusion in Cirrhosis With Refractory Ascites

Low‐dose Dopamine Infusion in Cirrhosis With Refractory Ascites

Response to Dopamine Hydrochloride in the Hepatorenal Syndrome

Systemic, splanchnic and renal hemodynamic effects of a dopaminergic dose of dopamine in patients with cirrhosis

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