of fluid were removed by thoracocentesis from the right side of his chest, and digitalis administration and diuretic therapy were adjusted. The patient was discharged in fair condition. Nine days later, he was readmitted with signs and symptoms of small bowel obstruction. Serum electrolyte levels on admission were as follows: sodium, 123 mEq/liter; potassium, 4 mEq/liter; carbon dioxide, 19 mEq/liter; and chloride, 93 mEq/liter. After intensive fluid and electrolyte therapy, values were within normal range

Anicteric hepatitis, associated with fever and exfoliative dermatitis, developed in a diabetic patient two weeks after intake of a long-acting sulfonylurea, chlorpropamide (Diabinese). Granulomas showing heavy infiltration with eosinophils were found in the liver and bone marrow. These were interpreted as manifestations of an allergic reaction. The clinical signs, abnormal laboratory findings, and hepatic lesions subsided spontaneously on withdrawal of the drug. Bone marrow changes, however, persisted seven months after cessation of the drug. To our knowledge, this is the first report of a patient with liver and bone marrow inflammation characterized by granulomas with eosinophilic infiltration following intake of chlorpropamide.

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