Effects of Intravitreal Silicone Oil on Subfoveal Choroidal Thickness

Karimi, Saeed; Entezari, Morteza; Nikkhah, Homayoun; Esfandiari, Hamed; Darvishpoor, Tahereh; Tavakoli, Mehdi; Safi, Sare

doi:10.1159/000485851

Cited by 21 publications

(24 citation statements)

References 29 publications

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“…Although silicone oil can provide a long duration of tamponade and enhances efficacy in difficult cases, applying the oil frequently leads to complications, such as keratopathy, glaucoma, or cataract [13][14][15][16]. Glaucoma is one of the most common complications following the use of silicone oil endotamponade, which occurs due to several pathophysiological mechanisms, including the pupillary block, inflammatory angle closure by synechiae, rubeosis of the iris, and migration of emulsified and non-emulsified silicone oil to the anterior chamber [14][15][16][17][18]. Infiltration and occlusion of the trabecular reticulum are believed to drive the pathophysiology of silicone-induced secondary open-angle glaucoma (OAG) [14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Methods of Endotamponade Used During 23-Gauge Pars Plana Vitrectomy and the Risk of Raised Intraocular Pressure During 24-Month Follow-Up: A Retrospective Study of 196 Patients

Lyssek-Boroń¹,

Krysik²,

Jankowska-Szmul³

et al. 2019

Med Sci Monit

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Departmental sources Background: Pars plana vitrectomy (PPV) is used to treat retinal conditions, including retinal detachment, and involves removal of the vitreous gel from the eye. Complications following PPV include raised intraocular pressure (IOP). This retrospective study aimed to compare methods of endotamponade used during 23-gauge PPV and the risk of raised IOP during 24-month follow-up at a single center. Material/Methods: The study included 196 patients (age, 15-86 years; mean, 63.5 years) (196 eyeballs). There were 93 patients (47.45%) with a preoperative history of type 2 diabetes mellitus and 14 patients (7.14%) with a history of myopia. IOP was measured with Goldmann applanation tonometry at one-, three-, six-, 12-, and 24-month follow-up. The outcome was compared following endotamponade with silicone oil, sulfur hexafluoride (SF6), and balanced salt solution (BSS). Results: Mean IOP at one-month follow-up was 17.2 mmHg (±3.61 mmHg; range, 9-45 mmHg), and at 24-month follow-up was 17.3 mmHg (±3.23 mmHg; range, 7-30 mmHg). IOP following PPV was significantly associated with the indication for PPV (P=0.023), and the type of endotamponade used (P=0.049). In patients with silicone oil endotamponade, the risk of IOP at 24 months was increased by 2.3 times compared with SF6 or BSS endotamponade. Patients with SF6 endotamponade had a risk of IOP that was 3.3 times lower than for silicone oil tamponade or BSS tamponade. Conclusions: Silicone oil endotamponade in PPV was associated with an increased risk of IOP at 24-month follow-up.

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Section: Discussionmentioning

confidence: 99%

Comparison of Methods of Endotamponade Used During 23-Gauge Pars Plana Vitrectomy and the Risk of Raised Intraocular Pressure During 24-Month Follow-Up: A Retrospective Study of 196 Patients

Lyssek-Boroń¹,

Krysik²,

Jankowska-Szmul³

et al. 2019

Med Sci Monit

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“…In this retrospective observational study, we observed a decrease in subfoveal choroidal thickness in the second month (8±2 weeks) following SO removal compared to the first month after the PPV and SO injection in patients who underwent PPV and SO injection due to RRD. Several studies have shown that choroidal thickness decreases after PPV (7)(8)(9). In a study regarding the changes in choroidal thickness in patients undergoing PPV and C3F8 injection due to RRD with macular involvement, it has shown that the subfoveal choroidal thickness has not changed (10).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Silicone Oil Endotamponade on Subfoveal Choroidal Thickness After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment

Bölükbaşı¹

2019

Beyoglu Eye J

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To evaluate the potential effects of 1000-cSt silicone oil (SO), which is used for pars plana vitrectomy (PPV) surgery on subfoveal choroidal thickness. Methods: In this retrospective study, 20 eyes of 20 patients who had undergone PPV and SO injection surgery for maculaoff rhegmatogenous retinal detachment were included. Complete ophthalmologic examinations were performed before the surgery, one month, three months after PPV and two months after silicone oil removal. After one month following PPV and SO injection and two months following silicone oil removal, subfoveal choroidal thickness was evaluated using EDI (enhanced depth imaging) mode of spectral-domain optical coherence tomography. Results: Subfoveal choroidal thickness measurements decreased statistically significantly at two months after silicone oil removal compared to the first month of PPV and SO injection. The mean subfoveal choroidal thickness was 284.2±54.2 µm at one month after PPV and SO injection, while it was 258.8±52.8 µm at two months after SO removal (p<0.001). Conclusion: After the removal of SO subfoveal choroidal thickness measurements decreased, the changes of subfoveal choroidal thickness measurements may be a parameter for the timing of SO removal.

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“…SO has been used world widely in complicated vitreoretinopathy, meanwhile many toxic effects on intraocular structures were substantialized, including iris, ciliary body, trabecular meshwork, retina and optic nerve, etc 6 7 . Recently many authors have proved foveal thickness decreasing, EZ disruption, and even choroidal thickness decreasing after SO endotamponade [8][9][10] . The exact mechanism of SO toxicity is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for ellipsoid zone integrity after macula-off rhegmatogenous retinal detachment repair

Fang

Chen

Zhai

et al. 2020

Preprint

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Background: ellipsoid zone (EZ) layer plays a vital role in visual performance of human retina, hereby we try to find some risk factors for EZ integrity after primary macula-off rhegmatogenous retinal detachment (RRD) repair. Methods: a retrospective cases study. Patients with macula-off RRD undergoing successful primary retinal repair surgery were reviewed and spectral domain optical coherence tomography images of them were analyzed. Comprehensive preoperative, intraoperative and postoperative clinical factors were screened. Results: A total of 118 patients (118 eyes) were enrolled in this study. The mean age of those patients was 52.16 years old (52.16 ±12.87 years). The follow-up time ranged from 0.1 to 84 months (10.21 ±14.81 months). 54 cases (45.76%) had their EZ fully reconstructed at final visit. The mid-quartile time of EZ reconstruction was 14.0 months (95% CI: 11.3 ~20.0 months). Multivariate proportional haphazard regression test revealed that the independent factors were: silicone oil tamponade (Hazard ratio=0.414, p=0.0400), posterior staphyloma (Hazard ratio=0.141, p=0.0021) and disorganization of retinal inner layer (Hazard ratio=0.167, p=0.0166). Conclusion: After successful retinal reattachment for macula-off retinal detachment, the mid-quartile time of EZ recovery was about 14 months. The independent risk factors for EZ recovery might include silicone oil tamponade, posterior staphyloma and disorganization of retinal inner layer.

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Effects of Intravitreal Silicone Oil on Subfoveal Choroidal Thickness

Cited by 21 publications

References 29 publications

Comparison of Methods of Endotamponade Used During 23-Gauge Pars Plana Vitrectomy and the Risk of Raised Intraocular Pressure During 24-Month Follow-Up: A Retrospective Study of 196 Patients

Comparison of Methods of Endotamponade Used During 23-Gauge Pars Plana Vitrectomy and the Risk of Raised Intraocular Pressure During 24-Month Follow-Up: A Retrospective Study of 196 Patients

The Effect of Silicone Oil Endotamponade on Subfoveal Choroidal Thickness After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment

Risk factors for ellipsoid zone integrity after macula-off rhegmatogenous retinal detachment repair

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