Effects of ionizing radiation on the mammalian brain

Hladik, Daniela; Tapio, Soile

doi:10.1016/j.mrrev.2016.08.003

Cited by 82 publications

(62 citation statements)

References 197 publications

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“…Folate is an example of a B vitamin that is concentrated in the CSF as it is transported across the BBB, and a disruption of the BBB can lead to localized cerebral folate deficiency without whole‐body folate deficiency (24). Spaceflight effects on the BBB are not known, but it is known that the endothelial cells of the BBB are sensitive to injury by ionizing radiation (25, 26).…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Astronaut ophthalmic syndrome

Zwart¹,

Gibson²,

Gregory

et al. 2017

The FASEB Journal

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During and after missions on the International Space Station, some astronauts experience ophthalmic changes, including choroidal folds, optic disc edema, cotton-wool spots, globe flattening, and refraction changes. Astronauts with ophthalmic issues had significantly higher plasma concentrations of metabolites that are associated with the 1-carbon metabolic pathway than those without ophthalmic issues. We hypothesized that genetic differences might explain the metabolite differences. Indeed, genetics and B vitamin status were significant predictors of ophthalmic issues. We now have developed a hypothesis regarding the mechanisms that link 1-carbon pathway genetics and the condition that we suggest calling, "astronaut ophthalmic syndrome." We maintain that this condition is genetically predisposed and is associated with endothelial dysfunction that is induced by oxidative stress. Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected individuals. Confirming this hypothesis will help characterize the genetics of 1-carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction, and cardiovascular and potentially other diseases.-Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome.

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Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Astronaut ophthalmic syndrome

Zwart¹,

Gibson²,

Gregory

et al. 2017

The FASEB Journal

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“…Hladik and Tapio review the epidemiology and biology of brain effects [3]. Shore provides an overview of cataract epidemiology [4], whereas Ainsbury et al reviews the biology of cataractogenesis following low linear energy transfer (LET) radiation exposures [5]; Hamada and Sato also review high-LET radiation cataractogenesis [6].…”

Section: Introductionmentioning

confidence: 99%

Special issue: Tissue reactions to ionizing radiation exposure

Hamada

Bouffler

Woloschak

2016

Mutation Research/Reviews in Mutation Research

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“…This has important implications for targeted tumor treatments as well as radiative conditioning prior to bone marrow transplantation (12). In our study, targeted radiation treatment of one hemisphere resulted in a significant supression of vasculature growth over the entire radiated hemisphere observed at 5 and 11 weeks following the procedure.…”

Section: Discussionmentioning

confidence: 60%

Intravital optoacoustic ultrasound bio-microscopy reveals radiation-inhibited skull angiogenesis

Estrada

Rebling

Sievert

et al. 2018

Preprint

Self Cite

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Angiogenesis is critical in bone development and growth. Dense, large-scale, and multi-layered vascular networks formed by thin-walled sinusoidal vessels perfuse the plate bones and play an important role in bone repair. Yet, the intricate functional morphology of skull microvasculature remains poorly understood as it is difficult to visualize using existing intravital microscopy techniques. Here we introduced an intravital fullytranscranial imaging approach based on hybrid optoacoustic and ultrasound bio-microscopy, allowing for large-scale observations and quantitative analysis of the vascular morphology, angiogenesis, vessel remodeling, and subsurface roughness in murine skulls. Our approach also enabled high-throughput physiological studies to understand radiation-inhibited angiogenesis in the skull bone. We observed previously undocumented sinusoidal vascular networks spanning the entire skullcap, thus opening new vistas for studying the complex interactions between calvarian, pial, and cortical vascular systems.

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Effects of ionizing radiation on the mammalian brain

Cited by 82 publications

References 197 publications

Astronaut ophthalmic syndrome

Astronaut ophthalmic syndrome

Special issue: Tissue reactions to ionizing radiation exposure

Intravital optoacoustic ultrasound bio-microscopy reveals radiation-inhibited skull angiogenesis

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