Special issue: Tissue reactions to ionizing radiation exposure

Hamada, Nobuyuki; Bouffler, Simon; Woloschak, Gayle E.

doi:10.1016/j.mrrev.2016.06.002

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…The most comprehensive study to date (Barnard et al 2019 ) exposed C57BL/6 mice to gamma-radiation at 0.84, 3.7, or 18 Gy/h, and found an inverse dose rate response in cataract formation in the lens of the eye. This supports previous epidemiological evidence as reviewed in Hamada et al ( 2016 ).…”

Section: Experimental Evidence Of a Dose Rate Effectsupporting

confidence: 93%

Radiation dose rate effects: what is new and what is needed?

Lowe¹,

Roy

Tabocchini

et al. 2022

Radiat Environ Biophys

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Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.

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Section: Experimental Evidence Of a Dose Rate Effectsupporting

confidence: 93%

Radiation dose rate effects: what is new and what is needed?

Lowe¹,

Roy

Tabocchini

et al. 2022

Radiat Environ Biophys

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“…This transcriptional response can considerably change on a quantitative and qualitative point of view, in function of cell type, dose and quality of radiation (Bufalieri et al, 2012;Giusti et al, 2014). Moreover, tissue response to irradiation is very complex and cannot be recapitulated by studies on isolated cell lines in active proliferation, involving completely different signaling pathways (Bufalieri et al, 2012;Fratini et al, 2011;Hamada et al, 2016;Licursi et al, 2017). Several studies suggested that the radiation response is not limited to the targeted cells but can propagate to surrounding cells and tissues, a phenomenon known as bystander effects (Brooks et al, 1974;Marín et al, 2015;Mothersill & Seymour, 2006) and even to untargeted organs (abscopal effects, (Mole, 1953;Yilmaz et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Transcriptional modulations induced by proton irradiation in mice skin in function of adsorbed dose and distance

Licursi

Wang

Nisio

et al. 2021

Journal of Radiation Research and Applied Sciences

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Hadron therapy by proton beams represents an advanced anti-cancer strategy due to its highly localized dose deposition allowing a greater sparing of normal tissue and/or organs at risk compared to photon/electron radiotherapy. However, it is not clear to what extent nontargeted effects such as transcriptional modulations produced along the beamline may diffuse and impact the surrounding tissue. In this work, we analyze the transcriptome of protonirradiated mouse skin and choose two biomarker genes to trace their modulation at different distances from the beam's target and at different doses and times from irradiation to understand to what extent and how far it may propagate, using RNA-Seq and quantitative RT-PCR. In parallel, assessment of lipids alteration is performed by FTIR spectroscopy as a measure of tissue damage. Despite the observed high individual variability of expression, we can show evidence of transcriptional modulation of two biomarker genes at considerable distance from the beam's target where a simulation system predicts a significantly lower adsorbed dose. The results are compatible with a model involving diffusion of transcripts or regulatory molecules from high dose irradiated cells to distant tissue's portions adsorbing a much lower fraction of radiation.

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